全文获取类型
收费全文 | 131024篇 |
免费 | 10921篇 |
国内免费 | 44篇 |
出版年
2021年 | 1303篇 |
2018年 | 1746篇 |
2017年 | 1620篇 |
2016年 | 2291篇 |
2015年 | 2756篇 |
2014年 | 3294篇 |
2013年 | 4564篇 |
2012年 | 5134篇 |
2011年 | 5334篇 |
2010年 | 3738篇 |
2009年 | 3281篇 |
2008年 | 4818篇 |
2007年 | 4824篇 |
2006年 | 4581篇 |
2005年 | 4487篇 |
2004年 | 4375篇 |
2003年 | 4263篇 |
2002年 | 4017篇 |
2001年 | 4798篇 |
2000年 | 4379篇 |
1999年 | 3605篇 |
1998年 | 1515篇 |
1997年 | 1375篇 |
1996年 | 1263篇 |
1995年 | 1113篇 |
1994年 | 1155篇 |
1993年 | 1134篇 |
1992年 | 2737篇 |
1991年 | 2714篇 |
1990年 | 2715篇 |
1989年 | 2431篇 |
1988年 | 2312篇 |
1987年 | 2220篇 |
1986年 | 2044篇 |
1985年 | 2117篇 |
1984年 | 1875篇 |
1983年 | 1600篇 |
1982年 | 1298篇 |
1981年 | 1302篇 |
1980年 | 1200篇 |
1979年 | 1688篇 |
1978年 | 1383篇 |
1977年 | 1287篇 |
1976年 | 1231篇 |
1975年 | 1335篇 |
1974年 | 1492篇 |
1973年 | 1530篇 |
1972年 | 1306篇 |
1971年 | 1137篇 |
1969年 | 1075篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
81.
82.
83.
A computer simulation model was developed to investigate nitrogenfluxes associated with microbial interactions in plankton communities.A short time scale was used, appropriate to the build-up anddecline of phytoplankton blooms in temperate shelf waters aftera mixing or upwelling event. The model depicts a continuum ofevents, many of which have been observed in coastal, upwellingand oceanic systems, including two phytoplankton peaks correspondingto new production and regenerated production.It predicts that nitrogen loss through sedimentation of phytoplanktonand faeces may result in a smaller bloom with a delayed onsetand prolonged duration. Microbial regeneration of nitrogen wasfound to be important in sustaining the middle stages of a phytoplanktonbloom, whereas micro- and meso-zooplankton regeneration occurredtowards the end of the bloom. 相似文献
84.
85.
86.
V. S. Oganov O. L. Vinogradova N. S. Dudov V. S. Baranov A. S. Minenkov A. V. Bakulin V. E. Novikov O. E. Kabitskaya M. V. Moskalenko A. S. Glotov O. S. Glotov D. V. Popov 《Human physiology》2008,34(2):182-190
The association of the polymorphism of the VDR, Col1a1, and CALCR genes with a form of osteoporosis frequently occurring as a consequence of intense physical exercise in athletes was studied. Biochemical parameters of bone remodeling and its neuroendocrine regulation, as well as the bone masses, of 22 amateur athletes were determined immediately before a strenuous nine-week training cycle (TC) and eight months later. The possible association of these factors with the polymorphism of the genes coding for bone tissue proteins was studied. Long-term intense physical training was found to be associated with a significant activation of bone tissue resorption accompanied by continued rapid synthesis. Nevertheless, and in spite of the strong activation of resorption caused by the TC, the athletes exhibited no osteoporosis (even eight months after the discontinuation of the TC); some of them, however, displayed an individual tendency to osteopenia. According to the results of genetic analysis, this was associated with the polymorphism of predisposition genes (genotype TT of the VDR gene and the functionally weakened s allele of the Col1a1 gene). 相似文献
87.
Larisa R. G. DeSantis Jessica R. Scott Blaine W. Schubert Shelly L. Donohue Brian M. McCray Courtney A. Van Stolk Amanda A. Winburn Michael A. Greshko Mackie C. O’Hara 《PloS one》2013,8(8)
The analysis of dental microwear is commonly used by paleontologists and anthropologists to clarify the diets of extinct species, including herbivorous and carnivorous mammals. Currently, there are numerous methods employed to quantify dental microwear, varying in the types of microscopes used, magnifications, and the characterization of wear in both two dimensions and three dimensions. Results from dental microwear studies utilizing different methods are not directly comparable and human quantification of wear features (e.g., pits and scratches) introduces interobserver error, with higher error being produced by less experienced individuals. Dental microwear texture analysis (DMTA), which analyzes microwear features in three dimensions, alleviates some of the problems surrounding two-dimensional microwear methods by reducing observer bias. Here, we assess the accuracy and comparability within and between 2D and 3D dental microwear analyses in herbivorous and carnivorous mammals at the same magnification. Specifically, we compare observer-generated 2D microwear data from photosimulations of the identical scanned areas of DMTA in extant African bovids and carnivorans using a scanning white light confocal microscope at 100x magnification. Using this magnification, dental microwear features quantified in 2D were able to separate grazing and frugivorous bovids using scratch frequency; however, DMTA variables were better able to discriminate between disparate dietary niches in both carnivorous and herbivorous mammals. Further, results demonstrate significant interobserver differences in 2D microwear data, with the microwear index remaining the least variable between experienced observers, consistent with prior research. Overall, our results highlight the importance of reducing observer error and analyzing dental microwear in three dimensions in order to consistently interpret diets accurately. 相似文献
88.
O Vuolteenaho 《Biochemical and biophysical research communications》1985,130(3):1226-1232
A specific radioimmunoassay was developed for beta-endorphin (1-18). The content of beta-endorphin (1-18) immunoreactivity in rat tissues was as follows: posterior pituitary 260 ng/fragment, anterior pituitary 1.46 ng/mg, hypothalamus 11.9 pg/mg. The levels were undetectable (less than 3 pg/mg) in extrahypothalamic brain, pancreas, small intestine, prostata and testis. Gel filtration and reverse-phase HPLC studies indicated that most of rat anterior pituitary immunoreactivity is due to native beta-endorphin (1-18), whereas the bulk of posterior pituitary immunoreactivity corresponds to more hydrophobic material, probably N-acetyl-beta-endorphin (1-18). Thus, beta-endorphin (1-18) is a quantitatively important novel pituitary peptide derived from proopiomelanocortin. The posterior pituitary is an especially rich source of (N-acetyl)-beta-endorphin (1-18). 相似文献
89.
Abstract: The phosphorylcholine concentration of rat brain rises and falls in response to parallel changes in the concentration of circulating choline. A single oral dose of choline chloride (20 mmol/kg) elevated whole-brain concentrations of both choline and phosphorylcholine 5 h after administration; a greater proportion of exogenously administered choline was retained by the brain in its phosphorylated form than as the free arnine. Striatal phosphorylcholine concentrations were elevated within 2 h of choline administration and continued to be significantly greater than control values for up to 34 h after treatment. The response of striatal choline levels to exogenous choline was of shorter duration than that of phosphorylcholine and was correlated with a significant increase in striatal acetylcholine concentrations. The consumption of a choline-free diet for 7 days lowered both serum choline and striatal phosphorylcholine concentrations, but had no effect on striatal choline or acetylcholine. These results suggest that choline kinase is unsaturated by its substrate in vivo and may thus serve to modulate the response of brain choline concentrations to alterations in the supply of circulating choline. 相似文献
90.