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71.
William Russell 《BMJ (Clinical research ed.)》1984,288(6416):580
72.
William A. Rottschaefer 《Theorie in den Biowissenschaften》2002,121(2):175-203
Summary Proponents of Developmental Systems Theory (DST) argue that it offers an alternative to current research programs in biology
that are built on the historic disjunction between evolutionary and developmental biology. In this paper I illustrate how
DST can be used to account for the acquisition of an important component of moral agency, conscience. Susan Oyama, a major
proponent of DST, has set moral issues outside the compass of DST. Thus, I examine her reasons for restricting DST to non-moral
matters, and argue that they are not decisive. On the positive side, I argue that DST not only is compatible with attempts
to describe and explain moral agency but also aids us in understanding it. In particular, I show how DST can provide a fruitful
perspective for viewing some significant current findings and theories in moral developmental psychology about the acquisition
of conscience. The familiar dichotomies resisted by DST, those between genes and environment, inherited and acquired, innate
and learned, and biological and cultural, have also plagued human developmental psychology, including moral development. By
bringing a DST perspective to the study of moral development, I illustrate how a DST perspective might offer a promising way
to reconceive that phenomenon, and provide some insights into how further work in understanding the development of moral agency
might proceed. Thus, I hope to contribute to the current efforts of proponents of DST to integrate developmental and evolutionary
considerations. 相似文献
73.
Thermal sensitivity of scope for activity in Pagothenia borchgrevinki, a cryopelagic Antarctic nototheniid fish 总被引:1,自引:1,他引:0
The thermal sensitivity of scope for activity was studied in the Antarctic nototheniid fish Pagothenia borchgrevinki. The scope for activity of P. borchgrevinki at 0°C was 189 mg O2 kg−1 h−1 (factorial scope 6.8) which is similar to that of temperate and tropical species at their environmental temperatures, providing no evidence for metabolic cold adaptation of maximum activity. The scope for activity increased to a maximum value of 266 mg O2 kg−1 h−1 (factorial scope 8.3) at 3°C and then decreased from 3 to 6°C. The thermal sensitivity of critical swimming speed was also investigated and followed a similar pattern to aerobic scope for activity, suggesting oxygen limitation of aerobic performance. Oxygen consumption rates and ventilation frequencies were monitored for 24 h after the swimming challenge and the recovery of both parameters to resting levels was rapid and independent of temperature. 相似文献
74.
Most microfluidic chips utilize off-chip hardware (syringe pumps, computer-controlled solenoid valves, pressure regulators, etc.) to control fluid flow on-chip. This expensive, bulky, and power-consuming hardware severely limits the utility of microfluidic instruments in resource-limited or point-of-care contexts, where the cost, size, and power consumption of the instrument must be limited. In this work, we present a technique for on-chip fluid control that requires no off-chip hardware. We accomplish this by using inert compounds to change the density of one fluid in the chip. If one fluid is made 2% more dense than a second fluid, when the fluids flow together under laminar flow the interface between the fluids quickly reorients to be orthogonal to Earth’s gravitational force. If the channel containing the fluids then splits into two channels, the amount of each fluid flowing into each channel is precisely determined by the angle of the channels relative to gravity. Thus, any fluid can be routed in any direction and mixed in any desired ratio on-chip simply by holding the chip at a certain angle. This approach allows for sophisticated control of on-chip fluids with no off-chip control hardware, significantly reducing the cost of microfluidic instruments in point-of-care or resource-limited settings. 相似文献
75.
William A. Calder 《Journal of theoretical biology》1982,98(3):393-400
Size-independent dimensional constants are proposed as a tool for analysis of life histories and community structure. The number of conspecific individuals occupying the average home-range in the long-run is 2·15 M?0·02, accomplished sequentially or socially at opposite ends of the mouse to wapiti body size range. Annual biomass turnover per species per hectare is also independent of body size, 0·93 N?0·04. 相似文献
76.
77.
A simple linear-operator model both describes and predicts the dynamics of choice that may underlie the matching relation. We measured inter-food choice within components of a schedule that presented seven different pairs of concurrent variable-interval schedules for 12 food deliveries each with no signals indicating which pair was in force. This measure of local choice was accurately described and predicted as obtained reinforcer sequences shifted it to favor one alternative or the other. The effect of a changeover delay was reflected in one parameter, the asymptote, whereas the effect of a difference in overall rate of food delivery was reflected in the other parameter, rate of approach to the asymptote. The model takes choice as a primary dependent variable, not derived by comparison between alternatives—an approach that agrees with the molar view of behaviour. 相似文献
78.
79.
80.
Matthew G. Permenter William E. Dennis Thomas E. Sutto David A. Jackson John A. Lewis Jonathan D. Stallings 《PloS one》2013,8(12)
Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, including military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. In order to further elucidate these mechanisms and identify potential biomarkers of exposure or effect, we exposed two rat liver-derived cell lines, H4-II-E-C3 and MH1C1, to two concentrations of cobalt chloride. We examined changes in gene expression using DNA microarrays in both cell lines and examined changes in cytoplasmic protein abundance in MH1C1 cells using mass spectrometry. We chose to closely examine differentially expressed genes and proteins changing in abundance in both cell lines in order to remove cell line specific effects. We identified enriched pathways, networks, and biological functions using commercial bioinformatic tools and manual annotation. Many of the genes, proteins, and pathways modulated by exposure to cobalt appear to be due to an induction of a hypoxic-like response and oxidative stress. Genes that may be differentially expressed due to a hypoxic-like response are involved in Hif-1α signaling, glycolysis, gluconeogenesis, and other energy metabolism related processes. Gene expression changes linked to oxidative stress are also known to be involved in the NRF2-mediated response, protein degradation, and glutathione production. Using microarray and mass spectrometry analysis, we were able to identify modulated genes and proteins, further elucidate the mechanisms of toxicity of cobalt, and identify biomarkers of exposure and effect in vitro, thus providing targets for focused in vivo studies. 相似文献