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751.
Multiple stressors threaten the imperiled coastal foundation species eelgrass (Zostera marina) in Chesapeake Bay,USA 下载免费PDF全文
Jonathan S. Lefcheck David J. Wilcox Rebecca R. Murphy Scott R. Marion Robert J. Orth 《Global Change Biology》2017,23(9):3474-3483
Interactions among global change stressors and their effects at large scales are often proposed, but seldom evaluated. This situation is primarily due to lack of comprehensive, sufficiently long‐term, and spatially extensive datasets. Seagrasses, which provide nursery habitat, improve water quality, and constitute a globally important carbon sink, are among the most vulnerable habitats on the planet. Here, we unite 31 years of high‐resolution aerial monitoring and water quality data to elucidate the patterns and drivers of eelgrass (Zostera marina) abundance in Chesapeake Bay, USA, one of the largest and most valuable estuaries in the world, with an unparalleled history of regulatory efforts. We show that eelgrass area has declined 29% in total since 1991, with wide‐ranging and severe ecological and economic consequences. We go on to identify an interaction between decreasing water clarity and warming temperatures as the primary drivers of this trend. Declining clarity has gradually reduced eelgrass cover the past two decades, primarily in deeper beds where light is already limiting. In shallow beds, however, reduced visibility exacerbates the physiological stress of acute warming, leading to recent instances of decline approaching 80%. While degraded water quality has long been known to influence underwater grasses worldwide, we demonstrate a clear and rapidly emerging interaction with climate change. We highlight the urgent need to integrate a broader perspective into local water quality management, in the Chesapeake Bay and in the many other coastal systems facing similar stressors. 相似文献
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Misty D. Smith Jose H. Woodhead Laura J. Handy Timothy H. Pruess Fabiola Vanegas Erin Grussendorf Joel Grussendorf Karen White Karolina K. Bulaj Reisa K. Krumin Megan Hunt Karen S. Wilcox 《Neurochemical research》2017,42(7):1995-2010
The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action in a battery of preclinical pain models in adult male CF#1 mice (formalin, writhing, and tail flick) and Sprague Dawley rats partial sciatic nerve ligation (PSNL). In the formalin assay, phenytoin (PHT, 6 mg/kg), sodium valproate (VPA, 300 mg/kg), amitriptyline (AMI, 7.5 and 15 mg/kg), gabapentin (GBP, 30 and 70 mg/kg), tiagabine (TGB, 5 and 15 mg/kg), and acetominophen (APAP, 250 and 500 mg/kg) reduced both phases of the formalin response to ≤?25% of vehicle-treated mice. In the acetic acid induced writhing assay, VPA (300 mg/kg), ethosuximide (ETX, 300 mg/kg), morphine (MOR, 5 & 10 mg/kg), GBP (10, 30, and 60 mg/kg), TGB (15 mg/kg), levetiracetam (LEV, 300 mg/kg), felbamate (FBM, 80 mg/kg) and APAP (250 mg/kg) reduced writhing to ≤?25% of vehicle-treated mice. In the tail flick test, MOR (1.25-5 mg/kg), AMI (15 mg/kg) and TGB (5 mg/kg) demonstrated significant antinociceptive effects. Finally, carbamazepine (CBZ, 20 and 50 mg/kg), VPA, MOR (2 and 4 mg/kg), AMI (12 mg/kg), TPM (100 mg/kg), lamotrigine (LTG, 40 mg/kg), GBP (60 mg/kg), TGB (15 mg/kg), FBM (35 mg/kg), and APAP (250 mg/kg) were effective in the PSNL model. Thus, TGB was the only prototype compound with significant analgesic effects in each of the four models, while AMI, GBP, APAP, and MOR each improved three of the four pain phenotypes. This study highlights the importance evaluating novel targets in a variety of pain phenotypes. 相似文献
754.
Phoebe Davies Simon Smith Rob Wilcox James D. Stewart Tania J. Davis Kylie McKenna Josh Hanson 《PLoS neglected tropical diseases》2022,16(7)
BackgroundPatients with rheumatic heart disease (RHD) and congestive cardiac failure (CCF) are believed to have an increased risk of melioidosis and are thought to be more likely to die from the infection. This study was performed to confirm these findings in a region with a high incidence of all three conditions.Principal findingsBetween January 1998 and December 2021 there were 392 cases of melioidosis in Far North Queensland, tropical Australia; 200/392 (51.0%) identified as an Indigenous Australian, and 337/392 (86.0%) had a confirmed predisposing comorbidity that increased risk for the infection. Overall, 46/392 (11.7%) died before hospital discharge; the case fatality rate declining during the study period (p for trend = 0.001).There were only 3/392 (0.8%) with confirmed RHD, all of whom had at least one other risk factor for melioidosis; all 3 survived to hospital discharge. Among the 200 Indigenous Australians in the cohort, 2 had confirmed RHD; not statistically greater than the prevalence of RHD in the local general Indigenous population (1.0% versus 1.2%, p = 1.0). RHD was present in only 1/193 (0.5%) cases of melioidosis diagnosed after October 2016, a period which coincided with prospective data collection. There were 26/392 (6.6%) with confirmed CCF, but all 26 had another traditional risk factor for melioidosis. Patients with CCF were more likely to also have chronic lung disease (OR (95% CI: 4.46 (1.93–10.31), p<0.001) and chronic kidney disease (odds ratio (OR) (95% confidence interval (CI): 2.98 (1.22–7.29), p = 0.01) than those who did not have CCF. Two patients with melioidosis and CCF died before hospital discharge; both were elderly (aged 81 and 91 years) and had significant comorbidity.ConclusionsIn this region of tropical Australia RHD and CCF do not appear to be independent risk factors for melioidosis and have limited prognostic utility. 相似文献
755.
Ahmed ZM Morell RJ Riazuddin S Gropman A Shaukat S Ahmad MM Mohiddin SA Fananapazir L Caruso RC Husnain T Khan SN Riazuddin S Griffith AJ Friedman TB Wilcox ER 《American journal of human genetics》2003,72(5):1315-1322
Cosegregation of profound, congenital deafness with markers on chromosome 6q13 in three Pakistani families defines a new recessive deafness locus, DFNB37. Haplotype analyses reveal a 6-cM linkage region, flanked by markers D6S1282 and D6S1031, that includes the gene encoding unconventional myosin VI. In families with recessively inherited deafness, DFNB37, our sequence analyses of MYO6 reveal a frameshift mutation (36-37insT), a nonsense mutation (R1166X), and a missense mutation (E216V). These mutations, along with a previously published missense allele linked to autosomal dominant progressive hearing loss (DFNA22), provide an allelic spectrum that probes the relationship between myosin VI dysfunction and the resulting phenotype. 相似文献
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Astrid Kodric-Brown Chris Wilcox Jason G. Bragg James H. Brown 《Diversity & distributions》2007,13(6):789-798
Human activities affect even the most remote and best preserved places on Earth. One of those places is Dalhousie Springs, Witjira National Park, in the arid centre of Australia. In 2003 we resurveyed the fish communities in springs to document changes since an earlier survey in 1991. Over the 12 years there were 18 population extirpations and only two colonizations, so total occurrences of five native species in 30 springs decreased from 83 to 67 populations. One species, the endemic Dalhousie goby, Chlamydogobius gloveri , accounted for 12 of the 18 population extirpations. Each fish species tended to persist in springs larger than some threshold size. Extirpations were related to spring size, with smaller springs more readily loosing populations, and to major habitat changes, which included large increases in the tropical reed Phragmites and concomitant decreases in open water, disturbed habitats, and dissolved oxygen. Extirpations of fish populations can be attributed primarily to habitat changes associated with reduced disturbance and herbivory as a result of the removal of feral livestock. These changes highlight the keystone impacts of large mammals on habitats and biotas of desert springs, and should be considered in management practices and policy decisions. 相似文献
758.
Recognition of the significance of the boundary between ecological systems, often referred to as the ecotone, has a long history
in the ecological sciences and in zoonotic disease research. More recent research in landscape ecology has produced an expanded
view of ecotones and elaboration of their characteristics and functions in ecosystems. Parallel research on emerging infectious
diseases (EIDs) and the causes of increased rates of pathogen transmission, spread, and adaptation suggests a correspondence
between ecotonal processes and the ecological and evolutionary processes responsible for zoonotic and vector-borne emerging
infections. A review of the literature suggests that ecotones play a role in a number of the most important EIDs. Yet these
are the only diseases for which specific landscape ecological information exists in the literature or disease reports. However,
the similar disease ecologies of these with about half of the approximately 130 zoonotic EIDs suggests ecotones, particularly
their anthropogenic origination or modification, may be generally associated with ecotones and the global trend of increasing
EIDs. 相似文献
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E. J. Milner-Gulland K. Shea H. Possingham T. Coulson C. Wilcox 《Animal Conservation》2001,4(2):157-167