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141.
Hansford Kayleigh M. McGinley Liz Wilkinson Samantha Gillingham Emma L. Cull Ben Gandy Sara Carter Daniel P. Vaux Alexander G. C. Richards Simon Hayes Alister Medlock Jolyon M. 《Experimental & applied acarology》2021,84(3):593-606
Experimental and Applied Acarology - Assessing the risk of tick-borne disease in areas with high visitor numbers is important from a public health perspective. Evidence suggests that tick presence,... 相似文献
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Ana G. Crisostomo Raphael B. Moreno Suppiah Navaratnam James A. Wilkinson 《Free radical research》2013,47(6):730-737
Three potential routes to generation of reactive oxygen species (ROS) from α-tocopherolquinone (α-TQ) have been identified. The quinone of the water-soluble vitamin E analogue Trolox C (Trol-Q) is reduced by hydrated electron and isopropanol α-hydroxyalkyl radical, and the resulting semiquinone reacts with molecular oxygen to form superoxide with a second order rate constant of 1.3 × 108 dm3/mol/s, illustrating the potential for redox cycling. Illumination (UV-A, 355 nm) of the quinone of 2,2,5,7,8-pentamethyl-6-hydroxychromanol (PMHC-Q) leads to a reactive short-lived (ca. 10? 6 s) triplet state, able to oxidise tryptophan with a second order rate constant greater than 109 dm3/mol/s. The triplet states of these quinones sensitize singlet oxygen formation with quantum yields of about 0.8. Such potentially damaging reactions of α-TQ may in part account for the recent findings that high levels of dietary vitamin E supplementation lack any beneficial effect and may lead to slightly enhanced levels of overall mortality. 相似文献
145.
This study explored the importance of using relevant measures when evaluating the effectiveness of early childhood interventions. Data from the federally-funded evaluation of the Comprehensive Child Development Program were used to examine whether the behavior measure, the Child Behavior Checklist (CBCL), was an appropriate tool for the diverse community-based sample of young, low-income children. Results demonstrated no confirmation of the CBCL syndromes composing the Externalizing and Internalizing behavioral dimensions used to determine program impacts. Exploratory analyses revealed that two-thirds of the clinical behavior problems included in the CBCL were of very low prevalence in this community-based sample. These findings stress the importance of measurement fit in national evaluations of early childhood programs serving these vulnerable children. 相似文献
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Alexandra M. Allen Gary L. A. Barker Paul Wilkinson Amanda Burridge Mark Winfield Jane Coghill Cristobal Uauy Simon Griffiths Peter Jack Simon Berry Peter Werner James P. E. Melichar Jane McDougall Rhian Gwilliam Phil Robinson Keith J. Edwards 《Plant biotechnology journal》2013,11(3):279-295
Globally, wheat is the most widely grown crop and one of the three most important crops for human and livestock feed. However, the complex nature of the wheat genome has, until recently, resulted in a lack of single nucleotide polymorphism (SNP)‐based molecular markers of practical use to wheat breeders. Recently, large numbers of SNP‐based wheat markers have been made available via the use of next‐generation sequencing combined with a variety of genotyping platforms. However, many of these markers and platforms have difficulty distinguishing between heterozygote and homozygote individuals and are therefore of limited use to wheat breeders carrying out commercial‐scale breeding programmes. To identify exome‐based co‐dominant SNP‐based assays, which are capable of distinguishing between heterozygotes and homozygotes, we have used targeted re‐sequencing of the wheat exome to generate large amounts of genomic sequences from eight varieties. Using a bioinformatics approach, these sequences have been used to identify 95 266 putative single nucleotide polymorphisms, of which 10 251 were classified as being putatively co‐dominant. Validation of a subset of these putative co‐dominant markers confirmed that 96% were true polymorphisms and 65% were co‐dominant SNP assays. The new co‐dominant markers described here are capable of genotypic classification of a segregating locus in polyploid wheat and can be used on a variety of genotyping platforms; as such, they represent a powerful tool for wheat breeders. These markers and related information have been made publically available on an interactive web‐based database to facilitate their use on genotyping programmes worldwide. 相似文献
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David T. Williams N. Straw M. Townsend A. S. Wilkinson A. Mullins 《Agricultural and Forest Entomology》2013,15(2):126-134
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Chloe I. Bloom Christine M. Graham Matthew P. R. Berry Fotini Rozakeas Paul S. Redford Yuanyuan Wang Zhaohui Xu Katalin A. Wilkinson Robert J. Wilkinson Yvonne Kendrick Gilles Devouassoux Tristan Ferry Makoto Miyara Diane Bouvry Valeyre Dominique Guy Gorochov Derek Blankenship Mitra Saadatian Phillip Vanhems Huw Beynon Rama Vancheeswaran Melissa Wickremasinghe Damien Chaussabel Jacques Banchereau Virginia Pascual Ling-pei Ho Marc Lipman Anne O’Garra 《PloS one》2013,8(8)
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In the face of demands for researchers to engage more actively with a wider range of publics and to capture different kinds of research impacts and engagements, we explored the ways a small number of environmental researchers use traditional and social media to disseminate research. A questionnaire was developed to investigate the impact of different media as a tool to broker contact between researchers and a variety of different stakeholders (for example, publics, other researchers, policymakers, journalists) as well as how researchers perceive that their use of these media has changed over the past five years. The questionnaire was sent to 504 researchers whose work had featured in a policy-oriented e-news service. 149 valid responses were received (29%). Coverage in traditional media (newspapers, broadcast) not only brokers contact with other journalists, but is a good source of contact from other researchers (n=47, 62%) and members of the public (n=36, 26%). Although the use of social media was limited amongst our sample, it did broker contact with other researchers (n=17, 47%) and the public (n=10, 28%). Nevertheless, few environmental researchers were actively using social media to disseminate their research findings, with many continuing to rely on academic journals and face-to-face communication to reach both academic and public audiences. 相似文献