全文获取类型
收费全文 | 15779篇 |
免费 | 1383篇 |
国内免费 | 1613篇 |
专业分类
18775篇 |
出版年
2024年 | 37篇 |
2023年 | 222篇 |
2022年 | 577篇 |
2021年 | 868篇 |
2020年 | 655篇 |
2019年 | 749篇 |
2018年 | 714篇 |
2017年 | 526篇 |
2016年 | 674篇 |
2015年 | 999篇 |
2014年 | 1153篇 |
2013年 | 1278篇 |
2012年 | 1529篇 |
2011年 | 1291篇 |
2010年 | 792篇 |
2009年 | 760篇 |
2008年 | 821篇 |
2007年 | 695篇 |
2006年 | 605篇 |
2005年 | 551篇 |
2004年 | 396篇 |
2003年 | 397篇 |
2002年 | 359篇 |
2001年 | 243篇 |
2000年 | 208篇 |
1999年 | 238篇 |
1998年 | 134篇 |
1997年 | 145篇 |
1996年 | 137篇 |
1995年 | 121篇 |
1994年 | 116篇 |
1993年 | 88篇 |
1992年 | 96篇 |
1991年 | 74篇 |
1990年 | 82篇 |
1989年 | 61篇 |
1988年 | 58篇 |
1987年 | 43篇 |
1986年 | 50篇 |
1985年 | 50篇 |
1984年 | 33篇 |
1983年 | 21篇 |
1982年 | 22篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 16篇 |
1978年 | 6篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1973年 | 9篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
861.
862.
863.
Wei Liu Li Liang Lifeng Zhao Huan Tan Jie Wu Qihui Qin Xiaojun Gou Xiaohua Sun 《Bioorganic & medicinal chemistry letters》2019,29(3):487-490
To explore the application of photoremovable protecting groups (PPGs) in the field of combination chemotherapy, we designed and synthesized a photoresponsive hybrid prodrug 4 that bearing both doxorubicin (DOX) and combretastatin A4 (CA4). Light triggered drug release investigation found that DOX release was mainly accomplished by 405?nm light while CA4 release was mainly triggered by 365?nm light, i.e., prodrug 4 exhibited a quasi-sequential release behavior when a sequential light irradiation strategy was applied. Cell viability evaluation confirmed the increased cytotoxicity of prodrug 4 compared with individual drugs towards MDA-MB-231cells, indicating that a synergistic effect was achieved. 相似文献
864.
865.
The ethylene response factor VaERF092 from Amur grape regulates the transcription factor VaWRKY33, improving cold tolerance 总被引:3,自引:0,他引:3
866.
Yun Ren Dan Chen Wenjie Li Dan Zhou Tao Luo Guoqiang Yuan Jing Zeng Ye Cao Zhongshan He Ting Zou Qiming Deng Shiquan Wang Aiping Zheng Jun Zhu Yueyang Liang Huainian Liu Lingxia Wang Ping Li Shuangcheng Li 《The Plant journal : for cell and molecular biology》2019,98(2):315-328
Meiosis is essential for eukaryotic sexual reproduction and plant fertility, and crossovers (COs) are essential for meiosis and the formation of new allelic combinations in gametes. In this study, we report the isolation of a meiotic gene, OsSHOC1, and the identification of its partner, OsPTD1. Osshoc1 was sterile both in male and female gametophytes, and it showed a striking reduction in the number of meiotic COs, indicating that OsSHOC1 was required for normal CO formation. Further investigations showed that OsSHOC1 physically interacted with OsPTD1 and that the latter was also required for normal CO formation and plant fertility. Additionally, the expression profiles of both genes were consistent with their functions. Our results suggest that OsSHOC1 and OsPTD1 are essential for rice fertility and CO formation, possibly by stabilizing the recombinant intermediates during meiosis. 相似文献
867.
868.
869.
870.