全文获取类型
收费全文 | 2612篇 |
免费 | 629篇 |
出版年
2022年 | 27篇 |
2021年 | 30篇 |
2019年 | 23篇 |
2018年 | 33篇 |
2016年 | 39篇 |
2015年 | 78篇 |
2014年 | 78篇 |
2013年 | 107篇 |
2012年 | 119篇 |
2011年 | 114篇 |
2010年 | 78篇 |
2009年 | 60篇 |
2008年 | 78篇 |
2007年 | 101篇 |
2006年 | 158篇 |
2005年 | 144篇 |
2004年 | 161篇 |
2003年 | 142篇 |
2002年 | 140篇 |
2001年 | 141篇 |
2000年 | 73篇 |
1999年 | 68篇 |
1998年 | 25篇 |
1997年 | 36篇 |
1996年 | 30篇 |
1995年 | 26篇 |
1994年 | 29篇 |
1993年 | 23篇 |
1992年 | 48篇 |
1991年 | 52篇 |
1990年 | 46篇 |
1989年 | 38篇 |
1988年 | 48篇 |
1987年 | 50篇 |
1986年 | 62篇 |
1985年 | 51篇 |
1984年 | 33篇 |
1983年 | 35篇 |
1981年 | 32篇 |
1980年 | 30篇 |
1979年 | 49篇 |
1977年 | 30篇 |
1976年 | 28篇 |
1975年 | 32篇 |
1974年 | 34篇 |
1973年 | 37篇 |
1972年 | 33篇 |
1971年 | 36篇 |
1970年 | 24篇 |
1969年 | 21篇 |
排序方式: 共有3241条查询结果,搜索用时 46 毫秒
991.
992.
Travis K. Warren Chris A. Whitehouse Jay Wells Lisa Welch Jay S. Charleston Alison Heald Donald K. Nichols Marc E. Mattix Gustavo Palacios Jeffrey R. Kugleman Patrick L. Iversen Sina Bavari 《PLoS neglected tropical diseases》2016,10(2)
Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene, was evaluated as a potential therapeutic intervention for MARV infection following delayed treatment of 1, 24, 48, and 96 h post-infection (PI) in a nonhuman primate lethal challenge model. A total of 30 cynomolgus macaques were divided into 5 groups of 6 and infected with 1,830 plaque forming units of MARV subcutaneously. AVI-7288 was administered by bolus infusion daily for 14 days at 15 mg/kg body weight. Survival was the primary endpoint of the study. While none (0 of 6) of the saline group survived, 83–100% of infected monkeys survived when treatment was initiated 1, 24, 48, or 96 h post-infection (PI). The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals. These data show that AVI-7288 protects NHPs against an otherwise lethal MARV infection when treatment is initiated up to 96 h PI. 相似文献
993.
Reassessing Ethnic Differences in Mean BMI and Changes Between 2007 and 2013 in English Children 下载免费PDF全文
994.
995.
William A. Wells 《The Journal of cell biology》2004,164(7):952-953
996.
997.
998.
999.
The US-Russian joint quail embryo project was designed to study the effects of microgravity on development of Japanese quail embryos incubated aboard Mir. For this part of the project, eyes from embryonic days 14 and 16 (E14 and E16) flight embryos were compared with eyes from several groups of ground-based control embryos. Measurements were recorded for eye weights; eye, corneal, and scleral ring diameters; and numbers of bones in scleral ossicle rings. Transparency of E16 corneas was documented, and immunohistochemical staining was performed to observe corneal innervation. In addition, corneal ultrastructure was observed at the electron microscopic level. Except for corneal diameter of E16 flight embryos, compared with that of one of the sets of controls, results reported here indicate that eye development occurred normally in microgravity. Fixation by cracking the shell and placing the egg in paraformaldehyde solution did not adequately preserve corneal nerves or cellular ultrastructure. 相似文献
1000.