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171.
Jesús Aguirre-Hernández Bruce S Milne Chris Queen Patricia CM O'Brien Tess Hoather Sean Haugland Malcolm A Ferguson-Smith Jane M Dobson David R Sargan 《BMC veterinary research》2009,5(1):1-18
Background
In dogs in the western world neoplasia constitutes the most frequently diagnosed cause of death. Although there appear to be similarities between canine and human cancers, rather little is known about the cytogenetic and molecular alterations in canine tumours. Different dog breeds are susceptible to different types of cancer, but the genetic basis of the great majority of these predispositions has yet to be discovered. In some retriever breeds there is a high incidence of soft tissue sarcomas and we have previously reported alterations of chromosomes 11 and 30 in two poorly differentiated fibrosarcomas. Here we extend our observations and present a case report on detail rearrangements on chromosome 11 as well as genetic variations in a tumour suppressor gene in normal dogs. 相似文献172.
Smid Eddy J Erkus Oylum Spus Maciej Wolkers-Rooijackers Judith CM Alexeeva Svetlana Kleerebezem Michiel 《Microbial cell factories》2014,13(1):1-9
This review describes the recent advances made in the studies of the microbial community of complex and undefined cheese starter cultures. We report on work related to the composition of the cultures at the level of genetic lineages, on the presence and activity of bacteriophages and on the population dynamics during cheese making and during starter culture propagation. Furthermore, the link between starter composition and starter functionality will be discussed. Finally, recent advances in predictive metabolic modelling of the multi-strain cultures will be discussed in the context of microbe-microbe interactions.
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The response of renin secretion rate (RSR) to acute systemic hypoxemia (mean arterial p02 34±8 torr) was studied in mechanically ventilated, anesthetized newborn lambs 5–10 days of age (n=6). Ventilation of these lambs with room air (normoxemia) was followed by administration of low oxygen inhaled gas mixture (fi02 0.11) which was associated with no change in arterial pC02, pH, mean arterial pressure (MAP), renal blood flow (RBF, measured by electromagnetic flow probe), and calculated renal vascular resistance (RVR). Arterial plasma renin activity (PRAA 4.28±1.73 to 6.46±3.00 ng AI/ml · hr), renal vein plasma renin activity (PRARV, 6.26±3.79 to 11.44±7.11 ng AI/ml · hr) and renin secretion rate (RSR, 19.86±21.70 to 51.32±48.54 units/min · KgBW) increased significantly (p<0.05) in response to hypoxemia. Restoration of normoxemia (arterial p02 100±18 torr) was associated with significant decline in MAP (to 65±14 mmHg) and RBF (to 9.0±2.1 ml/min · KgBW) and further increases in PRAA (to 8.98±3.40 ng AI/ml · hr), PRARV (to 19.04±10.62 ng AI/ml · hr) and RSR (to 88.6±77.6 units/min · KgBW). PRAA correlated strongly with PRARV (r=0.84) and RSR (r=0.60) in these lambs. These results suggest that PRAA, PRARV and RSR increase in response to hypoxemia in anesthetized lambs by a mechanism other than renal arterial baroreceptor stimulation, although this mechanism may be active during recovery from hypoxemia. Furthermore, PRAA closely approximates RSR in newborn lambs under these conditions. 相似文献
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