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591.
Ferreira Nadja I. Risch Verhaagh Manfred Heymann Eckhard W. 《Primates; journal of primatology》2021,62(6):871-877
Primates - Ants are the dominant group of animals in many habitats, particularly in tropical rainforests. High abundance and formation of large colonies convert them into a potential food source... 相似文献
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Birgitte M Haugan Kenneth A Halberg Åse Jespersen Lea R Prehn Nadja Møbjerg 《BMC developmental biology》2010,10(1):56
Background
Three kidney systems appear during vertebrate development: the pronephroi, mesonephroi and metanephroi. The pronephric duct is the first or primary ureter of these kidney systems. Its role as a key player in the induction of nephrogenic mesenchyme is well established. Here we investigate whether the duct is involved in urine modification using larvae of the freshwater amphibian Ambystoma mexicanum (axolotl) as model. 相似文献595.
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T Takeuchi E C Weinbach M Gottlieb L S Diamond 《Comparative biochemistry and physiology. B, Comparative biochemistry》1979,62(3):281-285
1. The enzymatic mechanism of oxygen uptake elicited by L-serine in axenically cultivated trophozoites of Entamoeba histolytica was investigated. 2. Of 22 amino acids examined, only L-serine stimulated oxygen consumption by intact and disrupted amoebae. 3. Pyruvate, a product of serine metabolism, also stimulated oxygen consumption in the amoebae. 4. Characterization of the oxygen uptake elicited by both L-serine and pyruvate, and analysis of the products of L-serine metabolism indicate that the amino acid is first converted to pyruvate. 5. L-Serine dehydratase, which catalyzes the deamination of serine to pyruvate, was detected primarily in the soluble fraction of the amoebae. D-Serine potently inhibited the enzyme, as well as oxygen uptake in the presence of L-serine but not in the presence of pyruvate. 6. The pyruvate formed is oxidized, at least in part, by a novel pyruvate oxidase involving the uptake of molecular oxygen. 相似文献
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Marc-Michael Zaruba Hans Diogenes Theiss Markus Vallaster Ursula Mehl Stefan Brunner Robert David Rebekka Fischer Lisa Krieg Eva Hirsch Bruno Huber Petra Nathan Lars Israel Axel Imhof Nadja Herbach Gerald Assmann Ruediger Wanke Josef Mueller-Hoecker Gerhard Steinbeck Wolfgang-Michael Franz 《Cell Stem Cell》2009,4(4):313-323
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Anke Tscheuschler Philipp Meffert Friedhelm Beyersdorf Claudia Heilmann Nadja Kocher Xenia Uffelmann Philipp Discher Matthias Siepe Fabian A. Kari 《PloS one》2016,11(11)
ObjectiveThe need for biological markers of aortic wall stress and risk of rupture or dissection of ascending aortic aneurysms is obvious. To date, wall stress cannot be related to a certain biological marker. We analyzed aortic tissue and serum for the presence of different MMP-2 isoforms to find a connection between serum and tissue MMP-2 and to evaluate the potential of different MMP-2 isoforms as markers of high wall stress.MethodsSerum and aortic tissue from n = 24 patients and serum from n = 19 healthy controls was analyzed by ELISA and gelatin zymography. 24 patients had ascending aortic aneurysms, 10 of them also had aortic root aneurysms. Three patients had normally functioning valves, 12 had regurgitation alone, eight had regurgitation and stenosis and one had only stenosis. Patients had bicuspid and tricuspid aortic valves (9/15). Serum samples were taken preoperatively, and the aortic wall specimen collected during surgical aortic repair.ResultsPro-MMP-2 was identified in all serum and tissue samples. Pro-MMP-2 was detected in all tissue and serum samples from patients with ascending aortic/aortic root aneurysms, irrespective of valve morphology or other clinical parameters and in serum from healthy controls. We also identified active MMP-2 in all tissue samples from patients with ascending aortic/aortic root aneurysms. None of the analyzed serum samples revealed signals relatable to active MMP-2. No correlation between aortic tissue total MMP-2 or tissue pro-MMP-2 or tissue active MMP-2 and serum MMP-2 was found and tissue MMP-2/pro-MMP-2/active MMP-2 did not correlate with aortic diameter. This evidence shows that pro-MMP-2 is the predominant MMP-2 species in serum of patients and healthy individuals and in aneurysmatic aortic tissue, irrespective of aortic valve configuration. Active MMP-2 species are either not released into systemic circulation or not detectable in serum. There is no reliable connection between aortic tissue—and serum MMP-2 isoforms, nor any indication that pro-MMP-2 functions as a common marker of high aortic wall stress. 相似文献
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