全文获取类型
收费全文 | 3086篇 |
免费 | 201篇 |
国内免费 | 139篇 |
专业分类
3426篇 |
出版年
2024年 | 14篇 |
2023年 | 65篇 |
2022年 | 144篇 |
2021年 | 247篇 |
2020年 | 169篇 |
2019年 | 212篇 |
2018年 | 193篇 |
2017年 | 134篇 |
2016年 | 198篇 |
2015年 | 255篇 |
2014年 | 334篇 |
2013年 | 329篇 |
2012年 | 314篇 |
2011年 | 278篇 |
2010年 | 138篇 |
2009年 | 105篇 |
2008年 | 103篇 |
2007年 | 79篇 |
2006年 | 41篇 |
2005年 | 35篇 |
2004年 | 20篇 |
2003年 | 9篇 |
2002年 | 6篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1959年 | 2篇 |
排序方式: 共有3426条查询结果,搜索用时 15 毫秒
61.
62.
63.
64.
Hongming Lv Zhenxiang Yu Yuwei Zheng Lidong Wang Xiaofeng Qin Genhong Cheng Xinxin Ci 《International journal of biological sciences》2016,12(1):72-86
Oxidative damage and inflammation are closely associated with the pathogenesis of acute lung injury (ALI). Thus, we explored the protective effect of isovitexin (IV), a glycosylflavonoid, in the context of ALI. To accomplish this, we created in vitro and in vivo models by respectively exposing macrophages to lipopolysaccharide (LPS) and using LPS to induce ALI in mice. In vitro, our results showed that IV treatment reduced LPS-induced pro-inflammatory cytokine secretion, iNOS and COX-2 expression and decreased the generation of ROS. Consistent findings were obtained in vivo. Additionally, IV inhibited H2O2-induced cytotoxicity and apoptosis. However, these effects were partially reversed following the use of an HO-1 inhibitor in vitro. Further studies revealed that IV significantly inhibited MAPK phosphorylation, reduced NF-κB nuclear translocation, and upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) expression in RAW 264.7 cells. In vivo, pretreatment with IV attenuated histopathological changes, infiltration of polymorphonuclear granulocytes and endothelial activation, decreased the expression of ICAM-1 and VCAM-1, reduced the levels of MPO and MDA, and increased the content of GSH and SOD in ALI. Furthermore, IV treatment effectively increased Nrf2 and HO-1 expression in lung tissues. Therefore, IV may offer a protective role against LPS-induced ALI by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. 相似文献
65.
Hai-Bin Dai Miao-Miao Xu Jia Lv Xiang-Jun Ji Si-Hai Zhu Ru-Meng Ma Xiao-Lei Miao Man-Lin Duan 《Molecular neurobiology》2016,53(7):4865-4873
66.
67.
Leilei Yin Yingying Fang Tao Song Dan Lv Zheng Wang Li Zhu Zihui Zhao Xinhua Yin 《Journal of cellular and molecular medicine》2019,23(4):2558-2567
Diabetic cardiomyopathy (DCM) is a condition associated with significant structural changes including cardiac tissue necrosis, localized fibrosis, and cardiomyocyte hypertrophy. This study sought to assess whether and how FBXL10 can attenuate DCM using a rat streptozotocin (STZ)‐induced DCM model system. In the current study, we found that FBXL10 expression was significantly decreased in diabetic rat hearts. FBXL10 protected cells from high glucose (HG)‐induced inflammation, oxidative stress, and apoptosis in vitro. In addition, FBXL10 significantly activated PKC β2 signaling pathway in H9c2 cells and rat model. The cardiomyocyte‐specific overexpression of FBXL10 at 12 weeks after the initial STZ administration attenuated oxidative stress and inflammation, thereby reducing cardiomyocyte death and preserving cardiac function in these animals. Moreover, FBXL10 protected against DCM via activation of the PKC β2 pathway. In conclusion, FBXL has the therapeutic potential for the treatment of DCM. 相似文献
68.
Xingjie Gao Jing Wang Meiqi Li Jia Wang Jian Lv Lu Zhang Caifeng Sun Jiamei Ji Wenbo Yang Zinan Zhao Weifeng Mao 《Journal of cellular and molecular medicine》2019,23(10):6797-6804
Berberine (BBR) is a natural isoquinoline alkaloid, which is used in traditional medicine for its anti‐microbial, anti‐protozoal, anti‐diarrhoeal activities. Berberine interacts with DNA and displays anti‐cancer activities, yet its effects on cellular DNA repair and on synthetic treatments with chemotherapeutic drugs remain unclear. In this study, we investigated the effects of BBR on DNA repair and on sensitization of breast cancer cells to different types of DNA damage anti‐tumoural drugs. We found BBR arrested cells in the cell cycle S phase and induced DNA breaks. Cell growth analysis showed BBR sensitized MDA‐MB‐231 cells to cisplatin, camptothecin and methyl methanesulfonate; however, BBR had no synergistic effects with hydroxurea and olaparib. These results suggest BBR only affects specific DNA repair pathways. Western blot showed BBR down‐regulated XRCC1 expressions, and the rescued XRCC1 recovered the resistance of cancer cells to BBR. Therefore, we conclude that BBR interferes with XRCC1‐mediated base excision repair to sensitize cancer cells to chemotherapeutic drugs. These finding can contribute to understanding the effects of BBR on cellular DNA repair and the clinical employment of BBR in treatment of breast cancer. 相似文献
69.
Chao Yang Fan Lv Yelong Zhang Jie Wen Kang Dong Hai Su Feili Lai Guoyu Qian Wei Wang Andr Hilger Yunhua Xu Yizhou Zhu Yida Deng Wenbin Hu Ingo Manke Yanan Chen 《Liver Transplantation》2019,9(46)
Developing low‐cost, high‐capacity, high‐rate, and robust earth‐abundant electrode materials for energy storage is critical for the practical and scalable application of advanced battery technologies. Herein, the first example of synthesizing 1D peapod‐like bimetallic Fe2VO4 nanorods confined in N‐doped carbon porous nanowires with internal void space (Fe2VO4?NC nanopeapods) as a high‐capacity and stable anode material for potassium‐ion batteries (KIBs) is reported. The peapod‐like Fe2VO4?NC nanopeapod heterostructures with interior void space and external carbon shell efficiently prevent the aggregation of the active materials, facilitate fast transportation of electrons and ions, and accommodate volume variation during the cycling process, which substantially boosts the rate and cycling performance of Fe2VO4. The Fe2VO4?NC electrode exhibits high reversible specific depotassiation capacity of 380 mAh g?1 at 100 mA g?1 after 60 cycles and remarkable rate capability as well as long cycling stability with a high capacity of 196 mAh g?1 at 4 A g?1 after 2300 cycles. The first‐principles calculations reveal that Fe2VO4?NC nanopeapods have high ionic/electronic conductivity characteristics and low diffusion barriers for K+‐intercalation. This study opens up new way for investigating high‐capacity metal oxide as high‐rate and robust electrode materials for KIBs. 相似文献
70.
The oxygen evolution reaction (OER) has aroused extensive interest from materials scientists in the past decade by virtue of its great significance in the energy storage/conversion systems such as water splitting, rechargeable metal–air batteries, carbon dioxide (CO2) reduction, and fuel cells. Among all the materials capable of catalyzing OER, layered double hydroxides (LDHs) stand out as one of the most effective electrocatalysts owing to their compositional and structural flexibility as well as the tenability and the simplicity of their preparation process. For this reason, numerous efforts have been dedicated to adjusting the structure, forming the well‐defined morphology, and developing the preparation methods of LDHs to promote their electrocatalytic performance. In this article, recent advances in the rational design of LDH‐based electrocatalysts toward OER are summarized. Specifically, various tactics for the synthetic methods, as well as structural and composition regulations of LDHs, are further highlighted, followed by a discussion on the influential factors for OER performance. Finally, the remaining challenges to investigate and improve the catalyzing ability of LDH electrocatalysts are stated to indicate possible future development of LDHs. 相似文献