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41.
Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu 《Cell research》2021,(4):415-432
Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Diseas... 相似文献
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Qiang Lv Shuang Han Lei Wang Jinchan Xia Peng Li Ruoyang Hu Jinzheng Wang Lei Gao Yuli Chen Yu Wang Jing Du Fang Bao Yong Hu Xingzhi Xu Wei Xiao Yikun He 《Nucleic acids research》2022,50(12):6820
Nitric oxide (NO) is a key player in numerous physiological processes. Excessive NO induces DNA damage, but how plants respond to this damage remains unclear. We screened and identified an Arabidopsis NO hypersensitive mutant and found it to be allelic to TEBICHI/POLQ, encoding DNA polymerase θ. The teb mutant plants were preferentially sensitive to NO- and its derivative peroxynitrite-induced DNA damage and subsequent double-strand breaks (DSBs). Inactivation of TEB caused the accumulation of spontaneous DSBs largely attributed to endogenous NO and was synergistic to DSB repair pathway mutations with respect to growth. These effects were manifested in the presence of NO-inducing agents and relieved by NO scavengers. NO induced G2/M cell cycle arrest in the teb mutant, indicative of stalled replication forks. Genetic analyses indicate that Polθ is required for translesion DNA synthesis across NO-induced lesions, but not oxidation-induced lesions. Whole-genome sequencing revealed that Polθ bypasses NO-induced base adducts in an error-free manner and generates mutations characteristic of Polθ-mediated end joining. Our experimental data collectively suggests that Polθ plays dual roles in protecting plants from NO-induced DNA damage. Since Polθ is conserved in higher eukaryotes, mammalian Polθ may also be required for balancing NO physiological signaling and genotoxicity. 相似文献
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黄土高原沟壑区王东沟小流域土壤有机碳空间分布 总被引:4,自引:1,他引:3
地貌和土地利用是影响土壤有机碳(Soil organic carbon,SOC)空间变异的重要因素。以黄土高原沟壑区王东沟小流域(8.3 km2)为对象,在考虑地貌单元和土地利用影响的基础上,采集0—20cm样品448个,0—200cm样品33个。研究了地貌单元(塬面、塬坡和沟道)和土地利用方式对SOC含量的影响。结果表明,地貌单元和土地利用对小流域表层和深层SOC的含量分布影响都有显著差异。0—20cm土层的SOC含量,沟道塬面塬坡;塬面表层SOC含量的变化平缓;塬坡和沟道SOC变异大于塬面。0—200cm土层SOC三地貌单元差异达极显著水平(P99.9%),塬面SOC含量最高(5.37g kg-1),塬坡(3.06 gkg-1)最低。不同地貌单元条件下土地利用方式对表层和剖面SOC含量分布的影响也存在明显差异。塬面区,人工草地SOC含量亦明显高于农田和果园,但仅40cm以上土层SOC达到显著差异。在塬坡上,不同土地利用类型间,发生显著差异深度达到140cm。沟道内,林草两种土地利用类型间的SOC含量无显著差异。在估算该地区SOC密度和储量时,需要充分考虑地貌单元和土地利用方式的影响。 相似文献
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Noor Khalidah Abdul Hamid Peace Onas Somdare Khadijah Abdullah Md Harashid Nurul Ain Othman Zulhisyam Abdul Kari Lee Seong Wei Mahmoud A.O. Dawood 《Saudi Journal of Biological Sciences》2022,29(5):3911
The purpose of this experiment was to examine the potential use of Carica papaya leaf extract as a supplement to promote growth and improve feed utilization in red hybrid tilapia. Five diets were formulated containing isolipidic (80 g/kg) and isonitrogenic (350 g/kg) levels. All feeds contained similar types and amounts of raw materials but differed in the inclusion of papaya leaf extract (0, 5, 10, 20 and 40 g/kg feed). The initial size of fish used was 2.3 ± 0.01 g. Each diet was performed in triplicate tanks, and the feeding period was 12 weeks. Fish fed diet containing 2% papaya leaf extract (PLE) had the highest final weight, 31.14 ± 1.47 g, followed by 1% PLE (27.27 ± 1.75 g). These two diets (1% and 2%) were also showed significant improvements of weight gain, SGR, and feed efficiency of the red hybrid tilapia (p < 0.05). However, papaya leaf extract did not affect the HSI, VSI, PER, digestive enzymes activity, blood composition, and survival rate. Supplementing the diets with papaya leaf extract lowered serum urea. Findings of this research suggest that adding papaya leaf extract to the diet of red hybrid tilapia improves growth and feed efficiency without adversely affecting blood parameters. Therefore, an inclusion level between 1% and 2% of the papaya leaf extract is recommended as a feed additive to promote red hybrid tilapia fry growth. 相似文献
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