全文获取类型
收费全文 | 498篇 |
免费 | 42篇 |
国内免费 | 1篇 |
专业分类
541篇 |
出版年
2021年 | 6篇 |
2020年 | 6篇 |
2018年 | 12篇 |
2017年 | 12篇 |
2016年 | 18篇 |
2015年 | 11篇 |
2014年 | 17篇 |
2013年 | 23篇 |
2012年 | 26篇 |
2011年 | 23篇 |
2010年 | 17篇 |
2009年 | 15篇 |
2008年 | 19篇 |
2007年 | 19篇 |
2006年 | 18篇 |
2005年 | 29篇 |
2004年 | 19篇 |
2003年 | 23篇 |
2002年 | 10篇 |
2001年 | 6篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 9篇 |
1997年 | 8篇 |
1995年 | 4篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 14篇 |
1991年 | 6篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 4篇 |
1981年 | 6篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1975年 | 7篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1970年 | 5篇 |
1969年 | 3篇 |
1966年 | 3篇 |
1962年 | 3篇 |
1961年 | 4篇 |
1888年 | 3篇 |
1887年 | 6篇 |
排序方式: 共有541条查询结果,搜索用时 0 毫秒
11.
12.
13.
14.
15.
16.
R.M. Warwick J.T. Davey J.M. Gee C.L. George 《Journal of experimental marine biology and ecology》1981,56(1):23-31
Gobies, Pomatoschistus microps (Krøeyer), were introduced to a series of cages on an estuarine mud-flat during the period in which the cover of Enteromorpha sp. was declining. They fed selectively on the grazers which either ingested Enteromorpha directly or browsed on micro-organisms attached to it and, therefore, significantly affected the breakdown rate of the alga. It is suggested that the balance between grazers and their predators may be at least partially responsible for the irregular development of Enteromorpha on estuarine mud-flats from year to year. 相似文献
17.
We investigated the activity of bombesin (BN), neuromedin-C (NM-C) and neuromedin-B (NM-B) on serotonin (5-HT) release and reuptake in rat hypothalamus (HYP) in vitro. BN and NM-C but not NM-B (all 1 microM) decreased K+ evoked 3H-5-HT release from superfused HYP slices by 25%. Bacitracin (BCN, 2 micrograms/ml), a nonspecific peptidase inhibitor, reversed the inhibitory effect of BN on K+ evoked 3H-5-HT release. Phosphoramidon (PAN, 10 microM) an endopeptidase 24.11 inhibitor, abolished the inhibitory effect of BN, but not NM-C, on K+ evoked 3H-5-HT release. The peptidyl dipeptidase A inhibitor enalaprilat (ENP, 10 microM), enhanced both BN and NM-C inhibition of 3H-5-HT release. Bestatin (BST, 10 microM) had no effect on BN or NM-C inhibitory activity on 3H-5-HT release. Neither BN, NM-C nor NM-B affected reuptake of 3H-5-HT into HYP synaptosomes alone or in combination with any of the peptidase inhibitors, nor did these peptides alter the ability of fluoxetine to inhibit 3H-5-HT uptake. These data suggest: a) that BN-like peptides may alter neurotransmission in the HYP by acting presynaptically on the 5-HT release mechanism; b) a similarity in the structural requirements for the BN induced inhibition of 5-HT release and BN evoked thermoregulatory disturbances; and c) that peptidases may selectively augment or reduce pharmacologic activity of BN-like peptides upon CNS administration. 相似文献
18.
19.
Amy J. E. Healey Matthew W. Farthing Francis K. E. Nunoo Warren M. Potts Warwick H. H. Sauer Ilze Skujina Nathan King Sophie de Becquevort Paul W. Shaw Niall J. McKeown 《Journal of fish biology》2020,96(3):795-805
Two sister species of horse mackerel (Trachurus trachurus and T. capensis) are described that are intensively harvested in East Atlantic waters. To address long-standing uncertainties as to their respective geographical ranges, overlap and intraspecific population structure this study combined genetic (mitochondrial DNA and microsatellite) analysis and targeted sampling of the hitherto understudied West African coast. mtDNA revealed two reciprocally monophyletic clades corresponding to each species with interspecies nuclear differentiation supported by FST values. The T. trachurus clade was found across the north-east Atlantic down to Ghana but was absent from Angolan and South African samples. The T. capensis clade was found only in South Africa, Angola and a single Ghanaian individual. This pattern suggests that both species may overlap in the waters around Ghana. The potential for cryptic hybridization and/or indiscriminate harvesting of both species in the region is discussed. For T. capensis mtDNA supports high gene flow across the Benguela upwelling system, which fits with the species' ecology. The data add to evidence of a lack of significant genetic structure throughout the range of T. trachurus though the assumption of demographic panmixia is cautioned against. For both species, resolution of stock recruitment heterogeneity relevant to fishery management, as well as potential hybridization, will require more powerful genomic analyses. 相似文献
20.
Yung‐Lin Hsieh Hong‐Yi Kuo Che‐Chang Chang Mandar T Naik Pei‐Hsin Liao Chun‐Chen Ho Tien‐Chi Huang Jen‐Chong Jeng Pang‐Hung Hsu Ming‐Daw Tsai Tai‐Huang Huang Hsiu‐Ming Shih 《The EMBO journal》2013,32(6):791-804
While numerous small ubiquitin‐like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular signalling mechanisms that differentially regulate substrate sumoylation. Here, we show that acetylation of SUMO E2 conjugase Ubc9 selectively downregulates the sumoylation of substrates with negatively charged amino acid‐dependent sumoylation motif (NDSM) consisting of clustered acidic residues located downstream from the core ψ‐K‐X‐E/D consensus motif, such as CBP and Elk‐1, but not substrates with core ψ‐K‐X‐E/D motif alone or SUMO‐interacting motif. Ubc9 is acetylated at residue K65 and K65 acetylation attenuates Ubc9 binding to NDSM substrates, causing a reduction in NDSM substrate sumoylation. Furthermore, Ubc9 K65 acetylation can be downregulated by hypoxia via SIRT1, and is correlated with hypoxia‐elicited modulation of sumoylation and target gene expression of CBP and Elk‐1 and cell survival. Our data suggest that Ubc9 acetylation/deacetylation serves as a dynamic switch for NDSM substrate sumoylation and we report a previously undescribed SIRT1/Ubc9 regulatory axis in the modulation of protein sumoylation and the hypoxia response. 相似文献