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排序方式: 共有178条查询结果,搜索用时 15 毫秒
171.
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J A Warrington S K Bailey E Armstrong O Aprelikova K Alitalo G M Dolganov A S Wilcox J M Sikela S F Wolfe M Lovett 《Genomics》1992,13(3):803-808
The distal portion of the long arm of human chromosome 5 contains an impressive number of genes encoding growth factors, growth factor receptors, and hormone/neurotransmitter receptors. The order of and relative distance between 18 of these genes was determined by radiation hybrid mapping. There is only a single gap in a contiguous radiation map from 5q22-5q35. For this set of radiation hybrids, one map unit (centiray) corresponds to 20-50 kb of DNA. Close physical proximity for several pairs of loci was predicted by the map. Two sets of these were found to be contained in single YAC clones. The physical map produced by radiation hybrid mapping should prove useful in efforts to identify four disease genes that have been assigned to distal 5q by linkage studies. 相似文献
173.
R C Warrington 《Analytical biochemistry》1974,62(1):204-216
A general procedure for the isolation of 3′-linked fragments derived from tRNA molecules is described. Purified N-2-naphthoxyacetylglycyl derivatives of the and of yeast were exhaustively digested with RNase T1 and the 3′-linked fragments (bearing the derivative) were separated from other degradation products (lacking the derivative) by stepwise chromatography on BD-cellulose. Subsequent chromatographic resolution and base-composition analysis allowed tentative identification of the 3′-terminals of and as Gp(Cp,Ap)CpCpA and Gp(Cp,Cp,Up,Ap)CpCpA, respectively. The potential utility of this procedure for development of a novel approach to nucleic acid sequence analysis is discussed. 相似文献
174.
Fraser Aitken Georgios Menelaou Oliver Warrington Rene S. Koolschijn Nadge Corbin Martina F. Callaghan Peter Kok 《PLoS biology》2020,18(12)
The way we perceive the world is strongly influenced by our expectations. In line with this, much recent research has revealed that prior expectations strongly modulate sensory processing. However, the neural circuitry through which the brain integrates external sensory inputs with internal expectation signals remains unknown. In order to understand the computational architecture of the cortex, we need to investigate the way these signals flow through the cortical layers. This is crucial because the different cortical layers have distinct intra- and interregional connectivity patterns, and therefore determining which layers are involved in a cortical computation can inform us on the sources and targets of these signals. Here, we used ultra-high field (7T) functional magnetic resonance imaging (fMRI) to reveal that prior expectations evoke stimulus-specific activity selectively in the deep layers of the primary visual cortex (V1). These findings are in line with predictive processing theories proposing that neurons in the deep cortical layers represent perceptual hypotheses and thereby shed light on the computational architecture of cortex.The way we perceive the world is strongly influenced by our expectations, but the neural circuitry through which the brain achieves this remains unknown. A study using ultra-high field fMRI reveals that prior expectations evoke stimulus-specific signals in the deep layers of the primary visual cortex. 相似文献
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A. M. Warrington 《CMAJ》1978,119(7):684-684,689
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