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Sreetharan Kanthaswamy O. R. P. Binida-Emonds C. Warden J. L. Viray D. G. Smith 《Primates; journal of primatology》2001,42(1):35-45
The use of simple sequence repeat (SSR) loci lacking length polymorphisms among their alleles (defined here as homozygotes)
in systemtic studies has thus far been largely ignored due to their apparent lack of genetic heterogeneity. However, in this
paper we show that point mutations, insertions, and deletions within SSR loci of identical size can be highly informative
for population genetic and evolutionary studies. Our preliminary study of the von Willebrand factor (vWF) locus shows that
there is a significant level of divergence among the Bornean Orangutans which implies that present orangutan subbopulations
in Borneo are genetically isolated from each other. However, our findings do not confirm that the Bornean and Sumatran Orangutans
form two separate clades. 相似文献
159.
Rodrigo Gularte-Mérida Charles R Farber Ricardo A Verdugo Alma Islas–Trejo Thomas R Famula Craig H Warden Juan F Medrano 《BMC genomics》2015,16(1)
Background
Mouse chromosome 2 is linked to growth and body fat phenotypes in many mouse crosses. With the goal to identify the underlying genes regulating growth and body fat on mouse chromosome 2, we developed five overlapping subcongenic strains that contained CAST/EiJ donor regions in a C57BL/6Jhg/hg background (hg is a spontaneous deletion of 500 Kb on mouse chromosome 10). To fine map QTL on distal mouse chromosome 2 a total of 1,712 F2 mice from the five subcongenic strains, plus 278 F2 mice from the HG2D founder congenic strain were phenotyped and analyzed. Interval mapping (IM) and composite IM (CIM) were performed on body weight and body fat traits on a combination of SNP and microsatellite markers, which generated a high-density genotyping panel.Results
Phenotypic analysis and interval mapping of total fat mass identified two QTL on distal mouse chromosome 2. One QTL between 150 and 161 Mb, Fatq2a, and the second between 173.3 and 175.6 Mb, Fatq2b. The two QTL reside in different congenic strains with significant total fat differences between homozygous cast/cast and b6/b6 littermates. Both of these QTL were previously identified only as a single QTL affecting body fat, Fatq2. Furthermore, through a novel approach referred here as replicated CIM, Fatq2b was mapped to the Gnas imprinted locus.Conclusions
The integration of subcongenic strains, high-density genotyping, and CIM succesfully partitioned two previously linked QTL 20 Mb apart, and the strongest QTL, Fatq2b, was fine mapped to a ~2.3 Mb region interval encompassing the Gnas imprinted locus.Electronic supplementary material
The online version of this article (doi:10.1186/s12864-014-1191-8) contains supplementary material, which is available to authorized users. 相似文献160.
Barbara York Alycia A. Truett Michelle P. Monteiro Sean J. Barry Craig H. Warden Jürgen K. Naggert Terry P. Maddatu David B. West 《Mammalian genome》1999,10(5):457-462
We have previously reported suggestive evidence for a locus on Chromosome (Chr) 7 that affects adiposity in F2 mice from a CAST/Ei × C57BL/6J intercross fed a high-fat diet. Here we characterize the effect of a high-fat (32.6 Kcal%
fat) diet on male and female congenic mice with a C57BL/6J background and a CAST/Ei-derived segment on Chr 7. Adiposity index
(AI) and weights of certain fat pads were approximately 50% lower in both male and female congenic mice than in control C57BL/6J
mice, and carcass fat content was significantly reduced. The reduction of fat depot weights was not seen, however, in congenic
animals fed a low-fat chow diet (12 Kcal% fat).
The congenic segment is approximately 25 cM in length, extending from D7Mit213 to D7Mit41, and includes the tub, Ucp2, and Ucp3, genes, all of which are candidate genes for this effect. Some polymorphisms have been found on comparing c-DNA sequences
of the Ucp2 gene from C57BL/6J and CAST/Ei mice. These results suggest that one or more genes present in the congenic segment modulate
the susceptibility to fat deposition on feeding a high-fat diet.
We were unable to show any significant difference between the energy intakes of the congenic and the control C57BL/6J mice
on the high-fat diet. Also, measurements of energy expenditure in male mice at 6 weeks of age, during the first 2 weeks of
exposure to the high-fat diet, failed to show any differences between control and congenic animals.
Received: 30 September 1998 / Accepted: 22 December 1998 相似文献