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141.
142.
Diba Borgmann Elisa Ciglieri Nasim Biglari Claus Brandt Anna Lena Cremer Heiko Backes Marc Tittgemeyer F. Thomas Wunderlich Jens C. Brüning Henning Fenselau 《Cell metabolism》2021,33(7):1466-1482.e7
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143.
Paul Kühn Amanda Ratier Backes Christine Rmermann Helge Bruelheide Sylvia Haider 《Annals of botany》2021,127(4):565
Background and AimsNon-native plant species are not restricted to lowlands, but increasingly are invading high elevations. While for both native and non-native species we expected variability of plant functional traits due to the changing environmental conditions along elevational gradients, we additionally assumed that non-native species are characterized by a more acquisitive growth strategy, as traits reflecting such a strategy have been found to correlate with invasion success. Furthermore, the typical lowland introduction of non-native species coming from multiple origins should lead to higher trait variability within populations of non-native species specifically at low elevations, and they might therefore occupy a larger total trait space.MethodsAlong an elevational gradient ranging from 55 to 1925 m a.s.l. on Tenerife, we collected leaves from eight replicate individuals in eight evenly distributed populations of five native and six non-native forb species. In each population, we measured ten eco-morphological and leaf biochemical traits and calculated trait variability within each population and the total trait space occupied by native and non-native species.Key ResultsWe found both positive (e.g. leaf dry matter content) and negative (e.g. leaf N) correlations with elevation for native species, but only few responses for non-native species. For non-native species, within-population variability of leaf dry matter content and specific leaf area decreased with elevation, but increased for native species. The total trait space occupied by all non-native species was smaller than and a subset of that of native species.ConclusionsWe found little evidence that intraspecific trait variability is associated with the success of non-native species to spread towards higher elevations. Instead, for non-native species, our results indicate that intermediate trait values that meet the requirements of various conditions are favourable across the changing environmental conditions along elevational gradients. As a consequence, this might prevent non-native species from overcoming abruptly changing environmental conditions, such as when crossing the treeline. 相似文献
144.
Some like it hot – and spicy: Chili and the capsaicin receptor TRPV1 Since many hundred years, many people like to eat chili pepper containing the pungent ingredient capsaicin that is responsible for making the food hot and spicy. Capsaicin activates transient receptor potential TRPV1 channels that are predominantly expressed in sensory neurons involved in pain sensation. TRPV1 is a noxious heat sensor and can also be activated by protons and several animal toxins. Thus, TRPV1 is a polymodal sensor of multiple noxious stimuli that cause pain. TRPV1 functions as a nocisensor that detects chemical and thermal stimuli and transduces this stimulation into sensory nerve impulses which leads to the perception of pain. Inhibition of TRPV1 reduces or abolishes pain sensation. A strong activation of TRPV1 induces a long-lasting refractory period of the pain-detecting system (desensitization) and may even lead to an irreversible loss of TRPV1-expressing sensory neurons. It still remains unclear why many people love hot and spicy food, accompanied by a burning sensation in the mouth. 相似文献
145.
Fabian Kern Lena Krammes Karin Danz Caroline Diener Tim Kehl Oliver Küchler Tobias Fehlmann Mustafa Kahraman Stefanie Rheinheimer Ernesto Aparicio-Puerta Sylvia Wagner Nicole Ludwig Christina Backes Hans-Peter Lenhof Hagen von
Briesen Martin Hart Andreas Keller Eckart Meese 《Nucleic acids research》2021,49(1):127
146.
147.
Jan Küntzer Christina Backes Torsten Blum Andreas Gerasch Michael Kaufmann Oliver Kohlbacher Hans-Peter Lenhof 《BMC bioinformatics》2007,8(1):367
Background
Technological advances in high-throughput techniques and efficient data acquisition methods have resulted in a massive amount of life science data. The data is stored in numerous databases that have been established over the last decades and are essential resources for scientists nowadays. However, the diversity of the databases and the underlying data models make it difficult to combine this information for solving complex problems in systems biology. Currently, researchers typically have to browse several, often highly focused, databases to obtain the required information. Hence, there is a pressing need for more efficient systems for integrating, analyzing, and interpreting these data. The standardization and virtual consolidation of the databases is a major challenge resulting in a unified access to a variety of data sources. 相似文献148.
P P Tamburini I Jansson L V Favreau W L Backes J B Schenkman 《Biochemical and biophysical research communications》1986,137(1):437-442
The interaction between NADPH-cytochrome P-450 reductase and a series of cytochrome P-450 isozymes was investigated using UV-visible spectrophotometry. In the absence of substrate the interactions between the reductase and RLM3, RLM5, and RLM5a were tight, exhibiting sub-micromolar dissociation constants and resulted in type I spectra of varying magnitude from which the following increases in the proportion of high spin hemoprotein were calculated; RLM3 (7%), RLM5 (36%), RLM5a (6%), LM2 (29%), RLM2 (0%). Preincubation of LM2 with its type I substrate benzphetamine increased the affinity of the cytochrome for the reductase. Using initial estimates of the P-450 spin states in the absence of reductase in conjunction with the spectral binding data and equations relating these parameters to the microequilibria for the association of reductase with high or low spin P-450, RLM3, RLM5, RLM5a and LM2 were shown to bind significantly more tightly to high spin P-450. The relevance of this data to the understanding of spin state influence on P-450 reduction is discussed. 相似文献
149.
Retention of cryptic genes in microbial populations 总被引:5,自引:0,他引:5
Cryptic genes are silenced genes that can still be reactivated by mutation.
Since they can make no positive contribution to the fitness of their
carriers, it is not clear why many cryptic genes in microbial populations
have not degenerated into useless DNA sequences. Hall et al. (1983) have
suggested that cryptic genes have persisted because of occasional strong
environmental selection for reactivated genes. The present mathematical
study supports their suggestion. It shows that a cryptic gene can be
retained without having any selective advantage over a useless DNA
sequence, if selection for the reactivated gene occasionally occurs for a
substantially long time.
相似文献
150.
Transcription analysis in Trypanosoma brucei 总被引:2,自引:0,他引:2
A W Cornelissen S Backes R Evers E J Grondal W Jess J K?ck 《Biochemical Society transactions》1990,18(5):710-714