Clinico-experimental study of the possibility of the use of immobilized enzymes for local thrombolysis and thromboformation

Fibrinolysin immobilized by a solid polysaccharide carrier capable of controllable biodegradation is shown to exert a local effective thrombolyzing action. Certain results of clinical studies of immobilized streptase (streptodecase) are presented. They show essential advantages of the new preparation over the known native enzymes. Experiments with animals show that the immobilized thrombin may be applied in therapeutic embolization for the hemorrhage cessation.     

Antibacterial and antiviral activity of the polychloroethyl- and beta,beta-dichlorovinylamides of carboxylic acids]

A number of compounds having antiviral and antibacterial (antistaphylococcal) activity was found in the beta,beta-dichlorvinyl- and alpha-chlor(alpha-oxy)-beta,beta,beta-trichlorethylamide series of carboxylic acids. The antistaphylococcal activity of the compounds under study was found to depend, to a certain extent, ontheir chemical structure, whereas no such dependence was established in respect of their antiviral activity. In the treatment of combined influenza-staphylococcal infection a decrease in antistaphylococcal effect was observed, while antiviral activity remained stable.     

The anticoagulant and antisclerotic effects of isopropoxygermatrane and methylethyl(silatrane-1-ylmethyl)sulfonium iodide

In the experiments on rabbits with experimental atherosclerosis the authors revealed lipolytic and antisclerotic effect of the above drug. It was also observed that it also possessed anticoagulation activity.     

The supramolecular organization of the keratinocyte cytoskeleton and extracellular matrix in human skin revealed by freezing-deep etching with rotary platinum-carbon shadow-casting

The supramolecular organization of the keratinocyte cytoskeleton, the basal lamina and of the dermal extracellular matrix in the whole human skin revealed by freeze-deep etching with Pt/C rotary shadowing is presented. The routine equipment for this method and sample preparation are described. The resolution of the method is sufficient to visualize individual cytoskeleton elements and extracellular matrix. The presented cytoskeleton organization is very similar to the meshwork of strands or "microtrabeculae" seen in the cytoplasm of the whole cells by high voltage electron microscopy. Besides, the ultrathin section pattern of epidermis in human skin from patients with mycosis fungoides is described.