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Panzade Kishor Prabhakar Vishwakarma Harinder Padaria Jasdeep Chatrath 《Molecular biology reports》2020,47(5):3821-3831
Molecular Biology Reports - Previously, we isolated CDS of Ziziphus nummularia isoform ZnJClpB1-C from heat stress-tolerant genotype Jaisalmer. To further functionally validate ZnJClpB1-C assumed... 相似文献
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Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells
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Madhavi Agrawal Prashant Kharkar Sonali Moghe Tushar Mahajan Vaishali Deka Chandni Thakkar Amrutha Nair Chirag Mehta Julie Bose Asha Kulkarni-Almeida Dilip Bhedi Ram A. Vishwakarma 《Bioorganic & medicinal chemistry letters》2013,23(20):5740-5743
With the aim to discover orally active small molecules that stimulate glucose uptake, high throughput screening of a library of 5000 drug-like compounds was conducted in differentiated skeletal muscle cells in presence of insulin. N-Substituted phthalazinone acetamide was identified as a potential glucose uptake modulator. Several novel derivatives were synthesized to establish structure activity relationships. Identified lead thiazolyl-phthalazinone acetamide (7114863) increased glucose uptake (EC50 of 0.07 ± 0.02 μM) in differentiated skeletal muscle cells in presence of insulin. Furthermore, 7114863 was superior to rosiglitazone under similar experimental conditions without inducing PPAR-γ agonist activity thus making it a very interesting scaffold. 相似文献