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621.
Luca Antonioli Carolina Pellegrini Matteo Fornai Erika Tirotta Daniela Gentile Laura Benvenuti Maria Cecilia Giron Valentina Caputi Ilaria Marsilio Genny Orso Nunzia Bernardini Cristina Segnani Chiara Ippolito Balázs Csóka Zoltán H. Németh György Haskó Carmelo Scarpignato Corrado Blandizzi Rocchina Colucci 《Purinergic signalling》2017,13(4):497-510
Adenosine A2B receptors (A2BR) regulate several enteric functions. However, their implication in the pathophysiology of intestinal dysmotility associated with high-fat diet (HFD)-induced obesity has not been elucidated. We investigated the expression of A2BR in mouse colon and their role in the mechanisms underlying the development of enteric dysmotility associated with obesity. Wild-type C57BL/6J mice were fed with HFD (60% kcal from fat) or normocaloric diet (NCD; 18% kcal from fat) for 8 weeks. Colonic A2BR localization was examined by immunofluorescence. The role of A2BR in the control of colonic motility was examined in functional experiments on longitudinal muscle preparations (LMPs). In NCD mice, A2BR were predominantly located in myenteric neurons; in HFD animals, their expression increased throughout the neuromuscular layer. Functionally, the A2BR antagonist MRS1754 enhanced electrically induced NK1-mediated tachykininergic contractions in LMPs from HFD mice, while it was less effective in tissues from NCD mice. The A2B receptor agonist BAY 60-6583 decreased colonic tachykininergic contractions in LMPs, with higher efficacy in preparations from obese mice. Both A2BR ligands did not affect contractions elicited by exogenous substance P. Obesity is related with a condition of colonic inflammation, leading to an increase of A2BR expression. A2BR, modulating the activity of excitatory tachykininergic nerves, participate to the enteric dysmotility associated with obesity. 相似文献
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623.
The Middle Miocene Marnoso-arenacea Formation at Deruta in the northern Apennines of Italy rests unconformably on an orogenic
wedge adjacent to the Adriatic foredeep. Based on a detailed facies analysis, the succession reveals two genetically related
depositional systems: a distal delta-fed sand-rich system and a more proximal fan-delta slope system. Petrographic data confirm
the genetic relationship between the two depositional systems, with the fan-delta slope feeding the basinward sand-rich system.
The Deruta depositional setting shows a multi-step sedimentary evolution controlled by tectonically induced relative sea-level
changes. The first stage, corresponding to a sea-level rise, promoted deposition in a wedge-top basin of pebbly sand and sand
lobes (delta-fed). The second stage, characterized by intense tectonic activity (uplift) and sea-level fall, promoted accumulation
of a prograding fan-delta slope replacing the sand-rich lobes. This phase was dominated by mass failures and methanogenic
cold seepages. During these two stages, the wedge-top basin was isolated from the adjacent foredeep. Only during the third
stage was a connection established, with the development of a deep-sea fan in the foredeep, fed by a deltaic depositional
system. 相似文献
624.
Emanuela Senatore Francesco Chiuso Laura Rinaldi Daniela Intartaglia Rossella Delle Donne Emilia Pedone Bruno Catalanotti Luciano Pirone Bianca Fiorillo Federica Moraca Giuliana Giamundo Giovanni Scala Andrea Raffeiner Omar TorresQuesada Eduard Stefan Marcel Kwiatkowski Alienke van Pijkeren Manuela Morleo Brunella Franco Corrado Garbi Ivan Conte Antonio Feliciello 《The EMBO journal》2021,40(10)
The primary cilium is a microtubule‐based sensory organelle that dynamically links signalling pathways to cell differentiation, growth, and development. Genetic defects of primary cilia are responsible for genetic disorders known as ciliopathies. Orofacial digital type I syndrome (OFDI) is an X‐linked congenital ciliopathy caused by mutations in the OFD1 gene and characterized by malformations of the face, oral cavity, digits and, in the majority of cases, polycystic kidney disease. OFD1 plays a key role in cilium biogenesis. However, the impact of signalling pathways and the role of the ubiquitin‐proteasome system (UPS) in the control of OFD1 stability remain unknown. Here, we identify a novel complex assembled at centrosomes by TBC1D31, including the E3 ubiquitin ligase praja2, protein kinase A (PKA), and OFD1. We show that TBC1D31 is essential for ciliogenesis. Mechanistically, upon G‐protein‐coupled receptor (GPCR)‐cAMP stimulation, PKA phosphorylates OFD1 at ser735, thus promoting OFD1 proteolysis through the praja2‐UPS circuitry. This pathway is essential for ciliogenesis. In addition, a non‐phosphorylatable OFD1 mutant dramatically affects cilium morphology and dynamics. Consistent with a role of the TBC1D31/praja2/OFD1 axis in ciliogenesis, alteration of this molecular network impairs ciliogenesis in vivo in Medaka fish, resulting in developmental defects. Our findings reveal a multifunctional transduction unit at the centrosome that links GPCR signalling to ubiquitylation and proteolysis of the ciliopathy protein OFD1, with important implications on cilium biology and development. Derangement of this control mechanism may underpin human genetic disorders. 相似文献
625.
Claudio Pettinari Ivan Timokhin Corrado Di Nicola Allan H. White 《Inorganica chimica acta》2011,367(1):98-107
Novel triorganotin(IV) derivatives of β-diketonate Q ligands (HQ in general, in detail HQfur = 1-phenyl-3-methyl-4-(2-furancarbonyl)-pyrazol-5-one, HQthi = 1-phenyl-3-methyl-4-(2-thienylcarbonyl)-pyrazol-5-one) of general formula (Q)SnR3·xH2O (R = Ph, x = 0; R = Bun or Me, x = 1) have been synthesized and spectroscopically and thermally characterized. Triphenyltin(IV) complexes have been isolated as anhydrous compounds while trialkyltin(IV) are always monohydrated. The structures of (Qfur)SnPh3 and (Qthi)SnMe3(OH2) are recorded. The tin atoms are five-coordinate in both. In the first, the pyrazolonate ligand behaves as an O,O′-bidentate; there are two similar but independent molecules in the structure. In the quasi-trigonal-bipyramidal environments, Sn-O(acyl) are 2.478(3), 2.364(3), Sn-O(pyrazolonate) 2.050(2), 2.079(2), Sn-C 2.123(4)-2.162(3) Å with the longer O(acyl) and a phenyl group quasi-trans (O-Sn-C 162.5(1), 160.8(1)°). In (Qthi)SnMe3(OH2), the three methyl groups are equatorial (Sn-C 2.1259(9)-2.1380(8) Å); Sn-O(Qthi,OH2) are 2.2143(5), 2.3350(6) Å, O-Sn-O 175.36(2)°. Trimethyltin(IV) derivatives decompose on heating with release of H2O and SnMe4 and formation of (Q)2SnMe2. Decomposition occurs also within two days after dissolution of (Q)SnMe3(OH2) in chloroform. 相似文献
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627.
Sébastien Lacroix Mario Lauria Marie-Pier Scott-Boyer Luca Marchetti Corrado Priami Laura Caberlotto 《Genes & nutrition》2015,10(6)
Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multi-omics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data.
Electronic supplementary material
The online version of this article (doi:10.1007/s12263-015-0508-9) contains supplementary material, which is available to authorized users. 相似文献628.
Daniele Arobba Maria Angela Guido Paola Minale Carlo Montanari Sandra Placereani Sabrina Pracilio Costantino Troise Susanna Voltolini Arsenio Corrado Negrini 《Aerobiologia》2000,16(2):233-243
A comparison between two pollen-sampling stationsin the city area of Genoa is presented. The samplingsites are placed 3 km apart, respectively in theeastern urban area (St. Martino Hospital – S.M.) andin the historical centre (Botanical Garden – B.G.).Pollen sampling was carried out during the years1995–1997 at the two different sites by volumetricHirst-type sampler and then compared. The dailyairborne pollen concentration of Urticaceae, Poaceae,Cupressaceae/Taxaceae, Corylaceae/Betulaceae andOleaceae resulted prevailingly higher at S.M., while a good correspondence was observed from a phenologicpoint of view. Asteraceae have shown the bestqualitative-quantitative consistency. In springtime adifference was recorded for Urticales, maybe due tolocal occurence (B.G.) of Broussonetia papyrifera(Moraceae). On the whole, the correspondence betweenthe two different sampling stations proved to besatisfactory. 相似文献
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630.