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21.
K. E. Popov B. N. Smetanin V. S. Gurfinkel' M. P. Kudinova V. Yu. Shlykov 《Neurophysiology》1986,18(6):548-554
A study was made on normal human subjects, using a stabilograph to investigate changes in posture produced in response to transcutaneous galvanic stimulation of the right labyrinth. Results were obtained for different head positions and under the illusion of head and trunk rotation produced by stimulating (vibrating) the gulteus maximus muscle. In the absence of illusion of movement, the direction of the vestibulomotor response was determined by the position of the head in relation to the feed: with the normal head position, the body swayed on a frontal plane, and on a sagittal plane when the heat turned through 90°. Vestibulomotor responses were sagittally oriented, as with real head turning, when illusory head and trunk turning through 90° was produced by vibration. When the illusion of head rotation (in relation to the feet) was not produced by this stimulus, the direction of the postural response was not produced by this stimulus, the direction of the postural response was determined by the real orientation of the head. It is concluded that the spatial perception system plays a major part in controlling spatially oriented vestibulomotor responses.Institute for Research into Information Transmission, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 18, No. 6, pp. 779–787, November–December, 1986. 相似文献
22.
The object of the work was to study changes in the ultrastructure of Candida utilis cells induced by increasing concentrations of glucose during chemostat cultivation and continuous cultivation with glucose pulse feeding. The results indicate that the cell structure and metabolism change vectorially with an increase of glucose concentration regardless of how glucose was added. An increase of the input glucose concentration is followed by an increase in the periplasmic space, the content of glycogen, the length and diameter of mitochondria, and the size of the nucleus. However, in the case of glucose pulse feeding, the above changes in the cell structure occur at a considerably lower input concentration as compared to the chemostat culture. Under these conditions, microtubuli are assembled in the cytoplasm in response to the glucose stimulus. 相似文献
23.
The first natural occurrence of 19-norcholestenone is reported, together with 17 sterols and one other delta 4-3-ketone in the extracts of the Californian gorgonian, Muricea californica (Aurivillius). Six additional demethyl sterols and five additional 4-monomethyl sterols which remain unidentified were also detected. Lipid extracts of M. californica from a winter and summer collection were split by various chromatographic methods into free sterol, steryl ester, and steryl conjugate fractions. Sterol compositions (determined by CG and CG-MS) of each fraction, subsequent to hydrolysis, are tabulated and discussed with respect to plausible origins of observed variations. The possible relationship of the Muricea 19-nor-steroidal ketone to other naturally occurring 19-nor-steroids is discussed. 相似文献
24.
Electrical unipolar monoaural stimulation of the labyrinth led to body sway mainly on a frontal plane in normal human subjects in a standing position. Early and late stages of response with latencies of 120–200 and 200–500 msec respectively changing in size in accordance with conditions of visual control were distinguished in the stabilographic response. Maximum response was recorded when the eyes were closed. Response declined upon opening the eyes, fixing the gaze on a static target, and with visual feedback according to stabilograms. The early and late components declined by 10–20 and 50–70% respectively in all cases. Fixing the gaze, in darkness, on an illuminated light spot stationary in relation to the head had no effect on level of response. Once the expected direction of body sway had been imparted, a significant and almost identical decrease of 70–80% in both components took place with the gaze fixed, however. Early and late components of vestibulomotor response are thought to be mediated by regulatory mechasisms with differing time courses and functional connections.Institute of Research into Information Transmission, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vo. 22, No. 1, pp. 80–87, January–February, 1990. 相似文献
25.
Methylmalonate semialdehyde dehydrogenase purified to homogeneity from rat liver possesses, in addition to its coupled aldehyde dehydrogenase and CoA ester synthetic activity, the ability to hydrolyze p-nitrophenyl acetate. The following observations suggest that this activity is an active site phenomenon: (a) p-nitrophenyl acetate hydrolysis was inhibited by malonate semialdehyde, substrate for the dehydrogenase reaction; (b) p-nitrophenyl acetate was a strong competitive inhibitor of the dehydrogenase activity; (c) NAD+ and NADH activated the esterase activity; (d) coenzyme A, acceptor of acyl groups in the dehydrogenase reaction, accelerated the esterase activity; and (e) the product of the esterase reaction proceeding in the presence of coenzyme A was acetyl-CoA. These findings suggest that an S-acyl enzyme (thioester intermediate) is likely common to both the esterase reaction and the aldehyde dehydrogenase/CoA ester synthetic reaction. 相似文献
26.
O C Ikonomov A G Stoynev I I Goranova-Stoyneva A Popov V A Minkova 《Acta physiologica Hungarica》1990,76(3):191-199
Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney. We found that due to the treatments applied in the protocol used for the investigation of pCPA effect on renin and vasopressin secretion in rats (300 mg/kg i.p. 64 and 40 h before sacrifice) renal injury was induced as well. Typical changes indicating acute renal failure were observed--an initial polyuria, natriuresis and body mass loss, succeeded by oliguria, decreased glomerular filtration rate, and salt and creatinine retention. Morphological changes in the glomeruli included a thickening of the basal membranes, a confluence and a reduced number of podocyte pedicles. A slight to moderate granular degeneration was observed in epithelial cells of the proximal convoluted tubule, combined with mitochondrial changes--an increase in number, matrix disorganization, and myelin degeneration. In conclusion, the renal function changes after i.p. pCPA may be due not to brain serotonin depletion-alone, but also to nephrotoxic effect. 相似文献
27.
V. V. Popov A. Y. Supin V. O. Klishin 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1996,178(4):571-578
Simultaneous tone-tone masking in conjunction with the envelope-following response (EFR) recording was used to obtain tuning curves in dolphins (Turslops truncatus). The EFR was evoked by amplitude-modulated probes of various frequencies. A modulation rate of 600 Hz was found to fit the requirement to have a narrow spectrum and evoke EFR of large amplitude. Tuning curves were obtained within the frequency range from 11.2 to 110 kHz. The Q10 values of the obtained tuning curves varied from 12–14 at the 11.2 kHz center frequency to 17–20 at the 64–90 kHz frequencies.Abbreviations
ABR
auditory brainstem response
-
EFR
envelope following response
-
ERB
equivalent rectangular bandwidth 相似文献
28.
M. V. Sergejeva A. V. Popov 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1994,174(3):381-389
- The ontogeny of positive phono taxis (PPT) in female crickets, Gryllus bimaculatus was followed in tethered flight. During the first day of adult life many females already demonstrated PPT to the calling song (CS) of conspecific males. The average threshold of PPT at 5 kHz, the dominant frequency of the CS, decreased by 30 dB by the time of sexual maturity (Fig. 1).
- No correlates of this decrease were found in the activity of the most sensitive ascending prothoracic neuron tuned to 5 kHz recorded in the neck connective. This is presumably the AN1 neuron which is known to be involved in PPT realization. Its threshold at 5 kHz in young animals was the same as in adults. Therefore, ascending circuits of PPT seem to be mature by the first day of imago life and there should be some other mechanisms preventing performance of PPT by young walking females until maturation.
- The PPT of females in flight is tuned to 5 kHz, much sharper than in walking (Fig. 2). In flight, the carrier frequency of a signal is probably an important parameter driving PPT, at least in a no-choice situation, whereas on the substrate, at close range, temporal parameters become decisive.
- The ontogenetic development of the selectivity of a female's PPT to temporal parameters of a signal passes 3 successive steps: 1) response mainly to the trill with pulse repetition rate as in the CS; 2) response mainly to the actual CS with chirp structure; 3) destruction of selectivity (Figs. 3–6). The existence of steps 1 and 2 strengthens our hypothesis, that in phylogeny, the trill (pulse rate) detector of the CS “recognizer” in the CNS appeared earlier, and was later accompanied by the chirp detector.
- Joint breeding of female larvae with males accelerates maturation of the CS recognizer.
29.
A. Y. Supin V. V. Popov V. O. Klishin 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1993,173(5):649-656
Tone-tone masking was used to determine auditory brain-stem response tuning curves in dolphins (Tursiops truncatus) in a simultaneous-masking paradigm. The Q
10 of the curves was as large as 16–19 in the frequency range 64–128 kHz. In the range 45–16 kHz, Q
10 decreased proportionally to the frequency with the bandwidth of the curves being constant, about 3.5–4 kHz at the 10-dB level. Tuning curves below 45 kHz are supposed to reflect broad spectral bandwidth of the probe's effective part which is no longer than 0.5 ms, irrespective of actual probe duration. Tuning curves above 64 kHz are supposed to reflect the real frequency tuning of the dolphin's auditory system.Abbreviations ABR
auditory brain stem response
- AP
action potential 相似文献
30.
G. V. Mukamolova N. D. Yanopolskaya T. V. Votyakova V. I. Popov A. S. Kaprelyants D. B. Kell 《Archives of microbiology》1995,163(5):373-379
Changes in the biochemical properties of Micrococcus luteus cells were studied during the transition to a dormant state after incubation in an extended stationary phase. The overall DNA content after 150 days of starvation was similar to its initial level, while the RNA content decreased by 50%. Total lipids and protein, phospholipids and membrane proteins declined rapidly within the first 1–10 days of starvation. After 180 days of starvation, cells contained 43% of the protein and 35% of the lipid initially present. Starvation for 120 days resulted in the loss of phosphatidylglycerol and, to some extent, of phosphatidylinositol, giving a membrane whose phospholipids consisted mainly of cardiolipin. The membrane fluidity declined during starvation, as judged by diphenyl hexatriene fluorescence anisotropy measurements. Oxidase activities declined to zero within the first 20–30 days of starvation, while the dehydrogenases and cytochromes were more stable. The activities of some cytoplasmic enzymes were lost very rapidly, while NADPH-linked isocitrate dehydrogenase had 30% of its initial activity after 120 days of starvation. For all parameters tested there were significant fluctuations during the first 10–20 days of starvation, which may reflect cryptic growth in the culture.Abbreviations
MPN
Most probable number
-
DPH
Diphenyl hexatriene 相似文献