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61.
Isoenzymes of vitamin-K-dependent carboxylase 总被引:2,自引:0,他引:2
M M Ulrich B A Soute M A de Boer-van den Berg C Vermeer 《Biochimica et biophysica acta》1985,830(1):105-108
Vitamin-K-dependent carboxylase was prepared from bovine liver, kidney, lung and testis and it was checked that these systems obeyed the laws of normal enzyme kinetics. Four carboxylatable substrates were obtained from different sources and the apparent Michaelis constants of the various carboxylases for these four substrates were measured. From the results thus obtained we concluded that carboxylase is a group name for a number of isoenzymes which are present in hepatic as well as in various non-hepatic tissues. 相似文献
62.
63.
64.
B A Soute W Müller-Esterl M A de Boer-van den Berg M Ulrich C Vermeer 《FEBS letters》1985,190(1):137-141
Here we describe the identification of a gamma-carboxyglutamic acid-containing protein in human spermatozoa. After thermal decarboxylation the protein is a good substrate for vitamin K-dependent carboxylase from various origins. A quick purification procedure for the decarboxylated protein is presented and in a preliminary characterization we have established its Mr (28 000-30 000) and its amino acid composition. 相似文献
65.
66.
B.A.M. Soute C. Vermeer M. De Metz H.C. Hemker H.R. Lijnen 《Biochimica et Biophysica Acta (BBA)/General Subjects》1981,676(1):101-107
Bovine descarboxyprothrombin and descarboxyfragment-1 can be used as substrates for rat and bovine vitamin K-dependent carboxylase. In both enzyme systems, however, these substrates have a high Km (0.3–0.4 mM). A better substrate (Km = 0.001–0.003 mM) was prepared from bovine descarboxyprothrombin by limited proteolysis with subtilisin Carlsberg. This substrate is called Fragment-Su and is composed of the amino acids 13–29 of descarboxyprothrombin. 相似文献
67.
In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase 总被引:3,自引:0,他引:3
In this paper, we describe the isolation and partial purification of an enzyme system that converts bovine decarboxyfactor II (PIVKA-II) into prothrombin (factor II). It is shown that the increase in factor II activity occurs in parallel with 14CO2 incorporation into BaSO4 adsorbable proteins. The system is not strictly vitamin K-dependent because it is obtained from the livers of normal healthy cows. By preincubating the enzyme(s) with an excess of warfarin, an absolute vitamin K1-dependence can be obtained. The reaction is inhibited by its own product, factor II. 相似文献
68.
Antonio J. Bóveda-Penalba Jan Vermeer Fernando Rodrigo Fernando Guerra-Vásquez 《International journal of primatology》2009,30(3):467-480
In 2007 we conducted a field study of almost 6 mo to determine the distribution of Callicebus oenanthe, formerly known as the Andean titi monkey. There previously has been no extensive study on the distribution and status by
other fieldworkers. We visited a total of 96 localities within or around the presumed distribution of this rare primate species
to determine the distribution of Callicebus oenanthe. We collected additional information on group size and threats to the species. Our expeditions revealed that the species
is not endemic to the Alto Mayo Valley, as earlier authors suggested, but that its distribution extends into the Bajo Mayo
and Huallaga Central. The study area is heavily deforested, and to date only one area was found where a viable population
might live, although further research is needed to confirm this. The species lives in the southern part of its distribution
in sympatry with another, undescribed species of Callicebus. We will continue the study to determine more precisely the distribution and conservation status of the Callicebus oenanthe, to determine if conservation measures are necessary for this species. This is the first activity of a long-term project
for the conservation of Callicebus oenanthe initiated by La Vallée des Singes Primate park. 相似文献
69.
Xiang Wan Can Yang Qiang Yang Hong Xue Nelson LS Tang Weichuan Yu 《BMC bioinformatics》2009,10(1):13-15
Background
The interactions of multiple single nucleotide polymorphisms (SNPs) are highly hypothesized to affect an individual's susceptibility to complex diseases. Although many works have been done to identify and quantify the importance of multi-SNP interactions, few of them could handle the genome wide data due to the combinatorial explosive search space and the difficulty to statistically evaluate the high-order interactions given limited samples. 相似文献70.
Brigida TL Lucena Billy M dos Santos João LS Moreira Ana Paula B Moreira Alvaro C Nunes Vasco Azevedo Anderson Miyoshi Fabiano L Thompson Marcos Antonio de MoraisJunior 《BMC microbiology》2010,10(1):298