全文获取类型
收费全文 | 1209篇 |
免费 | 100篇 |
国内免费 | 1篇 |
出版年
2023年 | 5篇 |
2022年 | 15篇 |
2021年 | 44篇 |
2020年 | 15篇 |
2019年 | 24篇 |
2018年 | 32篇 |
2017年 | 28篇 |
2016年 | 54篇 |
2015年 | 85篇 |
2014年 | 88篇 |
2013年 | 92篇 |
2012年 | 138篇 |
2011年 | 109篇 |
2010年 | 76篇 |
2009年 | 50篇 |
2008年 | 71篇 |
2007年 | 59篇 |
2006年 | 56篇 |
2005年 | 38篇 |
2004年 | 56篇 |
2003年 | 40篇 |
2002年 | 33篇 |
2001年 | 9篇 |
2000年 | 3篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 3篇 |
1965年 | 2篇 |
1957年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有1310条查询结果,搜索用时 31 毫秒
981.
Wei Yongjun Siewers Verena Nielsen Jens 《Applied microbiology and biotechnology》2017,101(9):3577-3585
Applied Microbiology and Biotechnology - Cocoa butter (CB) extracted from cocoa beans is the main raw material for chocolate production. However, growing chocolate demands and limited CB production... 相似文献
982.
Land management: data availability and process understanding for global change studies 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Global Change Biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Karl‐Heinz Erb Sebastiaan Luyssaert Patrick Meyfroidt Julia Pongratz Axel Don Silvia Kloster Tobias Kuemmerle Tamara Fetzel Richard Fuchs Martin Herold Helmut Haberl Chris D. Jones Erika Marín‐Spiotta Ian McCallum Eddy Robertson Verena Seufert Steffen Fritz Aude Valade Andrew Wiltshire Albertus J. Dolman 《Global Change Biology》2017,23(2):512-533
In the light of daunting global sustainability challenges such as climate change, biodiversity loss and food security, improving our understanding of the complex dynamics of the Earth system is crucial. However, large knowledge gaps related to the effects of land management persist, in particular those human‐induced changes in terrestrial ecosystems that do not result in land‐cover conversions. Here, we review the current state of knowledge of ten common land management activities for their biogeochemical and biophysical impacts, the level of process understanding and data availability. Our review shows that ca. one‐tenth of the ice‐free land surface is under intense human management, half under medium and one‐fifth under extensive management. Based on our review, we cluster these ten management activities into three groups: (i) management activities for which data sets are available, and for which a good knowledge base exists (cropland harvest and irrigation); (ii) management activities for which sufficient knowledge on biogeochemical and biophysical effects exists but robust global data sets are lacking (forest harvest, tree species selection, grazing and mowing harvest, N fertilization); and (iii) land management practices with severe data gaps concomitant with an unsatisfactory level of process understanding (crop species selection, artificial wetland drainage, tillage and fire management and crop residue management, an element of crop harvest). Although we identify multiple impediments to progress, we conclude that the current status of process understanding and data availability is sufficient to advance with incorporating management in, for example, Earth system or dynamic vegetation models in order to provide a systematic assessment of their role in the Earth system. This review contributes to a strategic prioritization of research efforts across multiple disciplines, including land system research, ecological research and Earth system modelling. 相似文献
983.
Verena Peters Claus P. Schmitt Tim Weigand Kristina Klingbeil Christian Thiel Antje van den Berg 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):1102-1110
In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity. Reduced glutathione (GSH), N-acetylcysteine and cysteine (3.2?±?0.4, 2.0?±?0.3, 1.6?±?0.2?µmol/mg/h/mM; p?.05) lowered dose-dependently recombinant CN1 (rCN1) efficiency (5.2?±?0.2?µmol/mg/h/mM) and normalized increased CN1 activity renal tissue samples of diabetic mice. Inhibition was allosteric. Substitution of rCN1 cysteine residues at position 102 (Mut1C102S) and 229 (Mut2C229S) revealed that only cysteine-102 is influenced by cysteinylation. Molecular dynamic simulation confirmed a conformational rearrangement of negatively charged residues surrounding the zinc ions causing a partial shift of the carnosine ammonium head and resulting in a less effective pose of the substrate within the catalytic cavity and decreased activity. Cysteine-compounds influence the dynamic behaviour of CN1 and therefore present a promising option for the treatment of diabetes. 相似文献
984.
Population genomics of the Asian tiger mosquito,Aedes albopictus: insights into the recent worldwide invasion
下载免费PDF全文
![点击此处可从《Ecology and evolution》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Panayiota Kotsakiozi Joshua B. Richardson Verena Pichler Guido Favia Ademir J. Martins Sandra Urbanelli Peter A. Armbruster Adalgisa Caccone 《Ecology and evolution》2017,7(23):10143-10157
Aedes albopictus, the “Asian tiger mosquito,” is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30–40 years. The species is of great public health concern as it can transmit at least 26 arboviruses, including dengue, chikungunya, and Zika viruses. In this study, using double‐digest Restriction site‐Associated DNA (ddRAD) sequencing, we developed a panel of ~58,000 single nucleotide polymorphisms (SNPs) based on 20 worldwide Ae. albopictus populations representing both the invasive and the native range. We used this genomic‐based approach to study the genetic structure and the differentiation of Ae. albopictus populations and to understand origin(s) and dynamics of the recent invasions. Our analyses indicated the existence of two major genetically differentiated population clusters, each one including both native and invasive populations. The detection of additional genetic structure within each major cluster supports that these SNPs can detect differentiation at a global and local scale, while the similar levels of genomic diversity between native and invasive range populations support the scenario of multiple invasions or colonization by a large number of propagules. Finally, our results revealed the possible source(s) of the recent invasion in Americas, Europe, and Africa, a finding with important implications for vector‐control strategies. 相似文献
985.
Jinlei Zhu Nataa Luki Verena Rajtschan Julia Walter Frank M. Schurr 《Ecology and evolution》2021,11(22):16239
Hydrology is a major environmental factor determining plant fitness, and hydrological niche segregation (HNS) has been widely used to explain species coexistence. Nevertheless, the distribution of plant species along hydrological gradients does not only depend on their hydrological niches but also depend on their seed dispersal, with dispersal either weakening or reinforcing the effects of HNS on coexistence. However, it is poorly understood how seed dispersal responds to hydrological conditions. To close this gap, we conducted a common‐garden experiment exposing five wind‐dispersed plant species (Bellis perennis, Chenopodium album, Crepis sancta, Hypochaeris glabra, and Hypochaeris radicata) to different hydrological conditions. We quantified the effects of hydrological conditions on seed production and dispersal traits, and simulated seed dispersal distances with a mechanistic dispersal model. We found species‐specific responses of seed production, seed dispersal traits, and predicted dispersal distances to hydrological conditions. Despite these species‐specific responses, there was a general positive relationship between seed production and dispersal distance: Plants growing in favorable hydrological conditions not only produce more seeds but also disperse them over longer distances. This arises mostly because plants growing in favorable environments grow taller and thus disperse their seeds over longer distances. We postulate that the positive relationship between seed production and dispersal may reduce the concentration of each species to the environments favorable for it, thus counteracting species coexistence. Moreover, the resulting asymmetrical gene flow from favorable to stressful habitats may slow down the microevolution of hydrological niches, causing evolutionary niche conservatism. Accounting for context‐dependent seed dispersal should thus improve ecological and evolutionary models for the spatial dynamics of plant populations and communities. 相似文献
986.
PII-like signalling molecules are trimeric proteins composed of 12-13 kDa polypeptides encoded by the glnB gene family. Heterologous expression of a cyanobacterial glnB gene in Escherichia coli leads to an inactivation of E. coli's own PII signalling system. In the present work, we show that this effect is caused by the formation of functionally inactive heterotrimers between the cyanobacterial glnB gene product and the E. coli PII paralogues GlnB and GlnK. This led to the discovery that GlnK and GlnB of E. coli also form heterotrimers with each other. The influence of the oligomerization partner on the function of the single subunit was studied using heterotrimerization with the Synechococcus PII protein. Uridylylation of GlnB and GlnK was less efficient but still possible within these heterotrimers. In contrast, the ability of GlnB-UMP to stimulate the adenylyl-removing activity of GlnE (glutamine synthetase adenylyltransferase/removase) was almost completely abolished, confirming that rapid deadenylylation of glutamine synthetase upon nitrogen stepdown requires functional homotrimeric GlnB protein. Remarkably, however, rapid adenylylation of glutamine synthetase upon exposing nitrogen-starved cells to ammonium was shown to occur in the absence of a functional GlnB/GlnK signalling system as efficiently as in its presence. 相似文献
987.
988.
Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dorsolateral prefrontal cortex (DLPFC) with slow repetitive transcranial magnetic stimulation (rTMS) leads to enhanced word memory performance. A total of 40 healthy human participants engaged in a list learning paradigm. Half of the participants (N = 20) received 1 Hz rTMS to the left DLPFC, while the other half (N = 20) received 1 Hz rTMS to the vertex and served as a control group. Participants receiving left DLPFC stimulation demonstrated enhanced memory performance compared to the control group. This effect was replicated in a within-subjects experiment where 24 participants received 1 Hz rTMS to the left DLPFC and vertex. In this second experiment, DLPFC stimulation also induced better memory performance compared to vertex stimulation. In addition to these behavioural effects, we found that 1 Hz rTMS to DLPFC induced stronger beta power modulation in posterior areas, a state that is known to be beneficial for memory encoding. Further analysis indicated that beta modulations did not have an oscillatory origin. Instead, the observed beta modulations were a result of a spectral tilt, suggesting inhibition of these parietal regions. These results show that applying 1 Hz rTMS to DLPFC, an area involved in episodic memory formation, improves memory performance via modulating neural activity in parietal regions.Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. An incidental finding from a simultaneous EEG-TMS experiment reveals that applying 1-Hz repetitive transcranial magnetic stimulation to this area of the brain improves memory performance by modulating neural activity in parietal regions. 相似文献
989.
990.
Clemens M. Grünbühel Helmut Haberl Heinz Schandl Verena Winiwarter 《Human ecology: an interdisciplinary journal》2003,31(1):53-86
Conceptualizing environmental problems as sustainability problems contributing to local and global environmental change requires an understanding of how societies cope with their natural environment. Indicators for society–nature interactions are fairly well developed for national-level analyses. This study adapts some of these indicators to the local level and relates them to a qualitative assessment of economic and cultural change in a single community. Indicators are derived from material and energy flow accounting methods and address two major objectives: Firstly, to identify mutual influences between the global and the local level. Secondly, to assess future potentials of environmental pressures and impacts that can be expected to occur as such communities follow a path of further modernization. This study of a small rice-farming community in Northeast Thailand deals with physical as well as sociocultural aspects in order to produce a broad picture of society–nature relations. The indicators developed portray a society in the midst of transition and rapid modernization. This becomes apparent when comparing the results to those of similar studies in traditional and industrial societies. What we see is a community struggling to adapt to global influences, while at the same time maintaining subsistence with traditional coping mechanisms. 相似文献