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51.
M. N. Repkova A. G. Venyaminova V. F. Zarytova 《Nucleosides, nucleotides & nucleic acids》2013,32(7-9):1797-1798
Abstract The synthesis and study of hybridzation and modification ability of the new oligo-ribonucleotide derivatives bearing p- azidotetrafluorobenzoic acid residue at the 5′-terminal phosphate is described. 相似文献
52.
Olga V. Gvozdeva IIya S. DovydenkoAlya G. Venyaminova Marina A. ZenkovaValentin V. Vlassov Elena L. Chernolovskaya 《FEBS letters》2014
DsRNAs longer than 30 bp induce interferon response and global changes in gene expression profile in mammalians. 21 bp siRNA and 25/27 bp dsiRNA acting via RNA interference mechanism are used for specific gene silencing in this class of organisms. We designed selectively 2′-O-methyl-modified 42 and 63 bp anti-MDR1-siRNAs that silence the expression of P-glycoprotein and restore the sensitivity of drug-resistant cancer cells to cytostatic more efficiently than canonical 21 bp siRNAs. We also show that they act in a Dicer-independent mode and are devoid of immunostimulating properties. Our findings suggest that 42 and 63 bp siRNAs could be used as potential therapeutics. 相似文献