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81.
Sharma VM Adi Seshu KV Chandra Sekhar V Madan S Vishnu B Babu PA Vamsee Krishna C Sreenu J Ravi Krishna V Venkateswarlu A Rajagopal S Ajaykumar R Kumar TS 《Bioorganic & medicinal chemistry letters》2004,14(1):67-71
A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400mg/kg doses were performed. 相似文献
82.
Kumar RS Ayyadurai N Pandiaraja P Reddy AV Venkateswarlu Y Prakash O Sakthivel N 《Journal of applied microbiology》2005,98(1):145-154
AIM: To study the antifungal activity and plant beneficial traits of a broad-spectrum antagonistic fluorescent pseudomonad strain, PUPa3. METHODS AND RESULTS: Strain PUPa3 was isolated from the rhizosphere soil of rice and identified as Pseudomonas aeruginosa on the basis of biochemical tests and by comparison of 16S rDNA sequences. This bacterium exhibits a broad-spectrum antifungal activity towards phytopathogenic fungi. The antifungal metabolite by PUPa3 was extracted, purified and characterized using nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Production of indole-3-acetic acid (IAA), siderophores, phosphatase and protease in PUPa3 was determined. Strain PUPa3 did not produce hydrogen cyanide, cellulase and pectinase. CONCLUSION: The antifungal metabolite produced by PUPa3 has been identified as phenazine-1-carboxamide (PCN) on the basis of NMR and MS data. Strain PUPa3 showed a broad-spectrum antifungal activity towards a range of phytopathogenic fungi. This bacterium also showed several plant growth-promoting traits but did not show the traits attributed to deleterious rhizobacteria. SIGNIFICANCE AND IMPACT OF THE STUDY: Present study reports the production of PCN as well as IAA for the first time by a saprophytic P. aeruginosa strain PUPa3. Because of the production of siderophore, growth hormone, protease and phosphatase and its innate fungicidal potential, this strain can be used as biofertilizer and antagonist against a range of phytopathogenic fungi that infect rice, groundnut, tobacco, chili, mango, sugarcane, tea, cotton and banana. 相似文献
83.
84.
Stewart R Song L Carter SM Sigalas C Zaccai NR Kanamarlapudi V Bhat MB Takeshima H Sitsapesan R 《The Journal of membrane biology》2008,222(2):65-77
Ryanodine receptor 2 (RyR2) cDNA has been available for more than 15 years; however, due to the complex nature of ligand gating
in this channel, many aspects of recombinant RyR2 function have been unresearched. We established a stable, inducible HEK
293 cell line expressing full-length rabbit RyR2 cDNA and assessed the single-channel properties of the recombinant RyR2,
with particular reference to ligand regulation with Ca2+ as the permeant ion. We found that the single-channel conductances of recombinant RyR2 and RyR2 isolated from cardiac muscle
are essentially identical, as is irreversible modification by ryanodine. Although it is known that RyR2 expressed in HEK 293
cells is not associated with FKBP12.6, we demonstrate that these channels do not exhibit any discernable disorganized gating
characteristics or subconductance states. We also show that the gating of recombinant RyR2 is indistinguishable from that
of channels isolated from cardiac muscle when activated by cytosolic Ca2+, caffeine or suramin. The mechanisms underlying ATP activation are also similar; however, the experiments highlighted a novel
effect of ATP at physiologically relevant concentrations of 5–10 mM. With Ca2+ as permeant ion, 5–10 mM ATP consistently inactivated recombinant channels (15/16 experiments). Such inactivation was rarely
observed with native RyR2 isolated from cardiac muscle (1 in 16 experiments). However, if the channels were purified, inactivation
by ATP was then revealed in all experiments. This action of ATP may be relevant for inactivation of sarcoplasmic reticulum
Ca2+ release during cardiac excitation–contraction coupling or may represent unnatural behavior that is revealed when RyR2 is
purified or expressed in noncardiac systems.
Richard Stewart and Lele Song—contributed equally to this work. 相似文献
85.
Novel analogues of (+)-varitriol have been synthesized via olefin cross-metathesis reaction using Grubb's catalyst. Newly synthesized compounds were screened for cytotoxicity and they showed mild activity against RAW264.7 and HT29 cell lines. 相似文献
86.
B. Siddhardha U. S. N. Murty M. Narasimhulu Y. Venkateswarlu 《Indian journal of microbiology》2010,50(2):225-228
Screening of Aspergillus funiculosus for bioactive secondary metabolites produced kojic acid, which is know to have wide range of biological properties. It is
very active against Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli, but moderately active against yeasts and Gram-positive bacteria except Staphylococcus epidermidis. Filamentous Fungi are more sensitive to kojic acid. When it exposed to larvicidal activity on Aedes aegypti third instar larvae are more sensitive than early fourth instar larvae. 相似文献
87.
G. Venkateswarlu P. S. Murali Krishna L. Venkateswar Rao 《Bioprocess and biosystems engineering》1999,20(1):27-30
Production of Rifamycin with Amycolatopsis mediterranei (MTCC14) was studied using carbon and locally available cheaper nitrogen sources. A. Mediterranei gave initial yield of 650 mg/l with standard fermentation medium. This was improved to 1400 mg/l by using various Carbon, Nitrogen sources and optimizing various cultural conditions. Glucose, Ammonium sulphate and combination of soya bean and pea nut meals were found to induce more Rifamycin production in 7 days with a pH of 7.2, temperature 28v°C. 相似文献
88.
V Ravikanth V L Niranjan Reddy P Ramesh T Prabhakar Rao P V Diwan A Khar Y Venkateswarlu 《Phytochemistry》2001,58(8):1263-1266
An immunosuppressive, tryptophan-derived alkaloid cristatin A (1), and two known compounds, cycloartenol and stigmasta-5,11(12)-diene-3 beta-ol, were isolated from the whole plant Lepidagathis cristata Willd. The structures of the isolates were established by interpretation of their spectral data. 相似文献
89.
Mallavarapu Megharaj Howard W. Pearson Professor Kadiyala Venkateswarlu 《Current microbiology》1993,27(1):41-45
Carbaryl and its major hydrolysis product, 1-naphthol, were tested singly and together at concentrations ranging from 2 to 20 g/ml towards photosynthesis, in vivo nitrate reductase activity and nitrogen fixation, and ultrastructure of a diazotrophic cyanobacterium,Nostoc linckia, isolated from soil. All three physiological processes tested were drastically affected and correlated well with the alterations in the ultrastructure of the organism. Combination of carbaryl and 1-naphthol, at different concentrations, interacted significantly, yielding additive, antagonistic, and synergistic responses. 相似文献
90.
M. Megharaj H. W. Pearson K. Venkateswarlu 《Applied microbiology and biotechnology》1993,39(4-5):644-648
A microalga, Chlorella vulgaris, and two diazotrophic cyanobacteria, Nostoc linckia and N. muscorum, all isolated from a rice soil, were compared for their response in terms of growth and metabolic activities to the application of carbofuran. The toxicity criteria included cell constituents (chlorophyll a, total protein, carbohydrate), 14CO2 uptake and nitrate reductase, besides nitrogenase activity (acetylene reduction) in the cyanobacteria. C. vulgaris and N. muscorum were more sensitive to carbofuran than was N. linckia. The significant toxicity of the insecticide, observed with higher concentrations of 20 and 50 g ml–1, to nitrogenase activity in N. linckia was reversed by the addition of ATP at 10 M. Transmission electron microscopy of the cultures, exposed to 50 g carbofuran ml–1 showed certain cellular abnormalities, indicating interference of the insecticide with membrane properties.
Correspondence to: K. Venkateswarlu 相似文献