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41.
Abinandan Sudharsanam Subashchandrabose Suresh R. Venkateswarlu Kadiyala Megharaj Mallavarapu 《Applied microbiology and biotechnology》2018,102(3):1131-1144
Applied Microbiology and Biotechnology - Microalgae and bacteria offer a huge potential in delving interest to study and explore various mechanisms under extreme environments. Acid mine drainage... 相似文献
42.
Goda Pankaja Kumar Sekhar Thuraka Thriveni Pinnu Venkateswarlu Annavarapu Peddanna Kotha Reddy Peduri Suresh Krishna Mypati Hari Sreelatha Tumma 《Russian Journal of Bioorganic Chemistry》2021,47(6):1293-1300
Russian Journal of Bioorganic Chemistry - A simple, convenient, environmentally benign method has been developed for the synthesis of spiro-5-cyanopyrimidines by multi-component condensation of... 相似文献
43.
Selva Rupa C. Immanuel Avinash D. Ghanate Dharmeshkumar S. Parmar Fiona Marriage Venkateswarlu Panchagnula Philip J. Day Anu Raghunathan 《Biochemical and biophysical research communications》2018,495(2):2010-2016
An authenticated U87MG clonal glioblastoma cell line was investigated to identify a sub-population of neurospheroidal (NSP) cells within the main epithelial population (U87MG). The NSP cells sorted using Fluorescence Assisted Cell Sorting (FACS) showed varied morphology, 30% lower growth rates, 40% higher IC50 values for temozolomide drug and could differentiate into the glial cell type (NDx). Metabolite profiling using HR-LCMS identified glucose, glutamine and serine in both populations and tryptophan only in U87MG as growth limiting substrates. Glycine, alanine, glutamate and proline were secreted by U87MG, however proline and glycine were re-utilized in NSP. Exo-metabolite profiling and phenotypic microarrays identified differential metabolism of primary carbon sources glucose and derived pyruvate for U87MG; glutamine and derived glutamate metabolism in NSP. Differential mRNA abundance of AKT1, PTEN, PIK3CA controlling metabolism, drug efflux, nutrient transport and epigenetic control MDM2 are potentially critical in shaping DNA methylation effects of temozolomide. Our study provides a new insight into the combined effect of these factors leading to temozolomide resistance in NSP. 相似文献
44.
Sudharsanam Abinandan Suresh R. Subashchandrabose Kadiyala Venkateswarlu 《Critical reviews in biotechnology》2018,38(8):1244-1260
Owing to certain drawbacks, such as energy-intensive operations in conventional modes of wastewater treatment (WWT), there has been an extensive search for alternative strategies in treatment technology. Biological modes for treating wastewaters are one of the finest technologies in terms of economy and efficiency. An integrated biological approach with chemical flocculation is being conventionally practiced in several-sewage and effluent treatment plants around the world. Overwhelming responsiveness to treat wastewaters especially by using microalgae is due to their simplest photosynthetic mechanism and ease of acclimation to various habitats. Microalgal technology, also known as phycoremediation, has been in use for WWT since 1950s. Various strategies for the cultivation of microalgae in WWT systems are evolving faster. However, the availability of innovative approaches for maximizing the treatment efficiency, coupled with biomass productivity, remains the major bottleneck for commercialization of microalgal technology. Investment costs and invasive parameters also delimit the use of microalgae in WWT. This review critically discusses the merits and demerits of microalgal cultivation strategies recently developed for maximum pollutant removal as well as biomass productivity. Also, the potential of algal biofilm technology in pollutant removal, and harvesting the microalgal biomass using different techniques have been highlighted. Finally, an economic assessment of the currently available methods has been made to validate microalgal cultivation in wastewater at the commercial level. 相似文献
45.
The effect of water deficit on nodulation, N2 fixation, photosynthesis, and total soluble sugars and leghemoglobin in nodules was investigated in cowpea and groundnut. Nitrogenase activity completely ceased in cowpea with a decrease in leaf water potential (
leaf) from –0.4 MPa to –0.9 MPa, while in groundnut it continued down to –1.7 MPa. With increasing water stress, the acetylene reduction activity (ARA) declined very sharply in cowpea, but ARA gradually decreased in groundnut. Even with mild water stress (
leaf of 0.2 MPa), nodule fresh weight declined 50% in cowpea partly due to a severe nodule shedding whereas nodule fresh weight declined in groundnut only when
leaf decreased by 1.0 MPa. No nodule shedding was noticed even at a higher stress level in groundnut. Photosynthesis and stomatal conductance were also more stable in groundnut than in cowpea under water stress. There was a sharp increase in total soluble sugars and leghemoglobin in the nodules of groundut with water stress, but no definite trend could be found in cowpea. 相似文献
46.
Summary Studies on the nature of relationship between grain size (in terms of thousand grain weight), grain number, rate of filling
and yield have been worked out with late duration (140–150 days) rice varieties. Grain number per m2, grains per panicle and yield showed a negative relationship with grain size. There was no compensatory balance between grain
size and grain number within a range of thousand grain weight of 15 to 30 g. Based on the peaks in grain filling activity,
the varieties were classified into four groups. There was no relationship between grain size and rate of grain filling thereby
suggesting that grain filling is determined by inherent endogenous factors. 相似文献
47.
The influence of soil application of carbofuran on the growth response of groundnut, and both mycorrhizal colonization and sporulation of Glomus clarum was studied in a pot culture experiment. Carbofuran application with or without mycorrhizal inoculation increased the height of the potted plants measured 8 weeks after sowing. Mycorrhizal plants were significantly taller than nonmycorrhizal plants at the final harvest time (14 weeks). Carbofuran, at the recommmended field dose of up to 2 kg/ha, greatly increased shoot dry matter and pod yield in mycorrhizal groundnut. Colonization and sporulation by this VAM fungus were also enhanced significantly at these dose levels. The application of carbofuran at 5 kg/ha inhibited both growth and mycorrhizal status of groundnut. 相似文献
48.
The problem of estimation of variance components based on diallel model for unbalanced data has been addressed. The least squares approach to quadratic estimation has been adopted in obtaining the explicit solutions for the design and genetic components of variance. 相似文献
49.
Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug 总被引:1,自引:0,他引:1
K. Venkateswarlu D.W. Denning N.J. Manning S.L. Kelly 《FEMS microbiology letters》1995,131(3):337-341
Abstract Mucosal candidosis is an almost inevitable consequence of AIDS. Resistance to fluconazole therapy associated with enhanced tolerance, detectable in microbiological estimation of sensitivity, occurs in up to 10% of cases with late-stage AIDS. We report here our biochemical analysis of the basis of resistance in a study of two susceptible and two resistant isolates. Resistance was not associated with a change in the target enzyme sterol 14α-demethylase, as indicated by equivalent levels of fluconazole inhibition of activity in extracts from all four isolates, or by mutations in sterol Δ 5,6 desaturase as previously observed in Saccharomyces cereuisiae and Ustilago maydis . Reduced cellular content of fluconazole in the resistant isolates of between six to ten-fold was observed which could account for their resistant phenotype. 相似文献
50.
Desmids of Andhra Pradesh,I from Pakhal Lake,Warangal 总被引:1,自引:1,他引:0