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Synthesis and antioxidative activity of 3',4',6,7-tetrahydroxyaurone, a metabolite of Bidens frondosa 总被引:1,自引:0,他引:1
Venkateswarlu S Panchagnula GK Subbaraju GV 《Bioscience, biotechnology, and biochemistry》2004,68(10):2183-2185
3',4',6,7-Tetrahydroxyaurone (1a), an aurone isolated from Bidens frondosa, and five analogues (1b-1f) were synthesized from pyrogallol in three steps. The antioxidative activity of 1a-1f was determined by the superoxide free radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging methods. 相似文献
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Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae 下载免费PDF全文
In Saccharomyces cerevisiae, replication through DNA lesions is promoted by Rad6-Rad18-dependent processes that include translesion synthesis by DNA polymerases eta and zeta and a Rad5-Mms2-Ubc13-controlled postreplicational repair (PRR) pathway which repairs the discontinuities in the newly synthesized DNA that form opposite from DNA lesions on the template strand. Here, we examine the contributions of the RAD51, RAD52, and RAD54 genes and of the RAD50 and XRS2 genes to the PRR of UV-damaged DNA. We find that deletions of the RAD51, RAD52, and RAD54 genes impair the efficiency of PRR and that almost all of the PRR is inhibited in the absence of both Rad5 and Rad52. We suggest a role for the Rad5 pathway when the lesion is located on the leading strand template and for the Rad52 pathway when the lesion is located on the lagging strand template. We surmise that both of these pathways operate in a nonrecombinational manner, Rad5 by mediating replication fork regression and template switching via its DNA helicase activity and Rad52 via a synthesis-dependent strand annealing mode. In addition, our results suggest a role for the Rad50 and Xrs2 proteins and thereby for the MRX complex in promoting PRR via both the Rad5 and Rad52 pathways. 相似文献
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Perera Isiri Adhiwarie Abinandan Sudharsanam Subashchandrabose Suresh R. Venkateswarlu Kadiyala Naidu Ravi Megharaj Mallavarapu 《Journal of applied phycology》2022,34(3):1311-1322
Journal of Applied Phycology - We investigated the role of extracellular metabolites released during mutualistic interactions in co-cultures of a microalga, Tetradesmus obliquus IS2 or Coelastrella... 相似文献
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Phyllodiaptomus sasikumari, a new species of calanoid copepod is described from the material collected in several ephemeral ponds and pools in the Palghat
District of Kerala State, South India. 相似文献
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Venkateswarlu Popuri Jing Huang Mahesh Ramamoorthy Takashi Tadokoro Deborah L. Croteau Vilhelm A. Bohr 《Nucleic acids research》2013,41(2):881-899
Humans have five RecQ helicases, whereas simpler organisms have only one. Little is known about whether and how these RecQ helicases co-operate and/or complement each other in response to cellular stress. Here we show that RECQL5 associates longer at laser-induced DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and that it interacts physically and functionally with WRN both in vivo and in vitro. RECQL5 co-operates with WRN on synthetic stalled replication fork-like structures and stimulates its helicase activity on DNA fork duplexes. Both RECQL5 and WRN re-localize from the nucleolus into the nucleus after replicative stress and significantly associate with each other during S-phase. Further, we show that RECQL5 is essential for cell survival in the absence of WRN. Loss of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instability and ultimately leads to cell death. Collectively, our results indicate that RECQL5 plays both co-operative and complementary roles with WRN. This is an early demonstration of a significant functional interplay and a novel synthetic lethal interaction among the human RecQ helicases. 相似文献