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381.
382.
In connection with some problems that arise in the study of neural networks random matrices are considered and the probability for them to have certain rank is investigated. Two models are studied in a simple-minded approach to problems of this type.On leave of absence from the Institute for Mathematical Sciences, Madras (India). 相似文献
383.
S. Tanuja N.D. Srinivas K.S.M.S. Raghava Rao M.K. Gowthaman 《Process Biochemistry》1997,32(8):635-641
A polymer/salt aqueous two-phase system has been successfully employed for separation and purification of amyloglucosidase. The effects of system pH, molecular weight of polymer and composition of the two-phase system on amyloglucosidase partition behaviour in polyethylene glycol (PEG 4000, 6000)/disodium hydrogen phosphate were investigated. Experimental data are explained based on Kim's theoretical model for the prediction of biomolecule partitioning in a PEG/salt system. 相似文献
384.
M R Wiley L C Weir S L Briggs N Y Chirgadze D Clawson D S Gifford-Moore A L Schacht G F Smith V Vasudevan L L Zornes V J Klimkowski 《Bioorganic & medicinal chemistry letters》1999,9(18):2767-2772
Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Derivatives of 4-(3-aminopropyl)-imidazole can be selective inhibitors of thrombin demonstrating potent anticoagulant activity. 相似文献
385.
386.
Uthaman Gowthaman Sathi Babu Chodisetti Pankaj Parihar Javed N. Agrewala 《Amino acids》2010,38(5):1333-1342
Since CD8+ T cell response is crucial to combat intracellular infections and cancer, identification of class I HLA binding peptides
is of immense clinical value. The experimental identification of such peptides is protracted and laborious. Exploiting in
silico tools to discover such peptides is an attractive alternative. However, this approach needs a thorough assessment before
its elaborate application. We have adopted a reverse approach to evaluate the reliability of eight different servers (inclusive
of 55 predictors) by exploiting experimentally proven data. A comprehensive data set of more than 960 peptides was employed
to test the efficacy of the programs. We have validated commonly used strategies to predict peptides that bind to seven most
prevalent HLA class I alleles. We conclude that four of the eight servers are more adept in predictions. Although the overall
predictions for class I MHC binders were superior to class II MHC binders, individual predictors for different alleles belonging
to the same program were highly variable in their efficiencies. We have also addressed whether a consensus approach can yield
better prediction efficiency. We observed that combining the results from different in silico programs could not increase
the efficiency significantly. 相似文献
387.
Anju Vasudevan 《Cell Adhesion & Migration》2009,3(2):198-Jun;3(2):198
388.
389.
K Suresh K Nirmala K Kuruvilla D M Vasudevan 《Indian journal of experimental biology》1989,27(6):497-501
Natural Killer activity assessed by 51Cr release assay from K-562 cells showed detectable activity from 5th day after tumour transplantation, reaching a peak on 12th day and thereafter showing a gradual decline in the activity. Antibody dependent cell mediated cytotoxicity estimated by 51Cr labelled sheep red blood cells anti SRBC system demonstrated a peak activity on 5th day. Cytotoxic T lymphocyte activity detected by 51Cr release of Dalton's lymphoma ascites target cells showed a peak on 10th day. Antibody complement mediated cytotoxicity revealed a similar pattern as natural killer cell activity. 相似文献
390.
T. Vijayakumar Ravindran Ankathil P. Remani V. K. Sasidharan K. K. Vijayan D. M. Vasudevan 《Cancer immunology, immunotherapy : CII》1986,22(1):76-79
Summary Serum immunoglobulin levels (IgG, IgA, IgM, IgD and IgE) were estimated in 196 patients with carcinoma of the oral cavity, 172 patients with cervical cancer and 166 patients with breast cancer. The values were compared with those of 50 patients with benign lesions of the breast and cervix and 100 healthy adult controls. Only the serum IgE levels were found to be elevated in the benign group. Serum IgA, IgD and IgE levels were found to be elevated in all the three types of cancers and the levels were found to increase with clinical stage. In carcinoma of uterine cervix IgG levels were also found to be elevated. Immunoglobulins A and D returned to normal after clinical cure whereas IgE remained slightly elevated. IgD and IgE remained high in patients who had residual cancer. 相似文献