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361.
André Zelanis Uilla Barcick Nathália de Vasconcellos Racorti Murilo Salardani 《Proteomics》2023,23(23-24):2200243
Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the main modulators of such biological responses. Hence, profiling cell line secretomes may be an opportunity for the identification of “signatures” of specific cell types (i.e., stromal or metastatic cells) with important prognostic/therapeutic value. This review will focus on the biological implications of cell secretomes in the context of cancer, as well as their functional roles in shaping the tumoral microenvironment (TME) and communication status of participating cells. 相似文献
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K van Oers A W Santure I De Cauwer N EM van Bers R PMA Crooijmans B C Sheldon M E Visser J Slate M AM Groenen 《Heredity》2014,112(3):307-316
Linking variation in quantitative traits to variation in the genome is an important, but
challenging task in the study of life-history evolution. Linkage maps provide a valuable
tool for the unravelling of such trait−gene associations. Moreover, they give
insight into recombination landscapes and between-species karyotype evolution. Here we
used genotype data, generated from a 10k single-nucleotide polymorphism (SNP) chip, of
over 2000 individuals to produce high-density linkage maps of the great tit (Parus
major), a passerine bird that serves as a model species for ecological and
evolutionary questions. We created independent maps from two distinct populations: a
captive F2-cross from The Netherlands (NL) and a wild population from the United Kingdom
(UK). The two maps contained 6554 SNPs in 32 linkage groups, spanning 2010 cM and
1917 cM for the NL and UK populations, respectively, and were similar in size and
marker order. Subtle levels of heterochiasmy within and between chromosomes were
remarkably consistent between the populations, suggesting that the local departures from
sex-equal recombination rates have evolved. This key and surprising result would have been
impossible to detect if only one population was mapped. A comparison with zebra finch
Taeniopygia guttata, chicken Gallus gallus and the green anole lizard
Anolis carolinensis genomes provided further insight into the evolution of
avian karyotypes. 相似文献
366.
Agustín Martinelli Thiago da Silva Marinho Felipe Mesquita de Vasconcellos Cristiane Monteiro dos Santos Luiz Carlos Borges Ribeiro Simony Monteiro dos Santos 《Ichnos》2013,20(4):173-180
Tooth marks on sandstone in an area of the Cerrado Biome are reported, indicating geophagy. The tooth marks were found on reddish sandstones cropping out in a pasture environment with typical components of the Cerrado Biome, in the Municipality of Campina Verde, Triângulo Mineiro region (west Minas Gerais State, Brazil). Studies have shown that the soil of the Cerrado is acid, with a low concentration of nutrients and minerals (also present in the plants living on this environment), which usually produce an alimentary deficiency in herbivorous animals. Therefore, these tooth marks indicate geophagy, in order to extract extra minerals from these sandstone levels, which have a high concentration of calcium carbonate and iron. The tooth marks consist of two parallel concave grooves and a medial prominent crest which results from the action of the incisors of mammals. Although the identification of the gnawing species for these sets of tooth marks are estimates at best, after wide comparisons we tentatively suggest that the tooth marks are most likely the result of the action of the incisors of rodents, such as Dasyprocta or Coendou. 相似文献
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The caste developmental system of the Neotropical termite Constrictotermes cyphergaster was investigated in 12 natural colonies from the semi-arid Caatinga region of northeastern Brazil. Twelve measurements were taken of different body parts of the larvae, workers, presoldiers,
soldiers, nymphs, and alates for morphometric analyses, and principal component analyses (PCA) were performed based on these
parameters. The nymphal line comprised one larval instar, followed by five nymphal instars, and alates, in agreement with
the developmental pattern described for Termitidae species. The apterous line included two larval instars, followed by workers,
presoldiers, and soldiers. Both workers and soldiers were found to be monomorphic and composed only of male specimens, with
only one instar phase each. C. cyphergaster, like most of the Nasutitermitinae, has only male soldiers. The presence of male workers, with only one instar, suggests
a simplified system of differentiation in the apterous line of C. cyphergaster. These patterns, which had not previously been described for ‘full nasute’ Nasutitermitinae, are similar to the differentiation
patterns of the ‘mandibulate nasute’ Cornitermes walkeri. 相似文献
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