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991.
Chengyang Han Hongyi Wang Amanda C. Hahn Claire I. Fisher Michal Kandrik Vanessa Fasolt Danielle K. Morrison Anthony J. Lee Iris J. Holzleitner Lisa M. DeBruine Benedict C. Jones 《Evolution and human behavior》2018,39(2):154-159
Effects of facial coloration on facial attractiveness judgments are hypothesized to be “universal” (i.e., similar across cultures). Cross-cultural similarity in facial color preferences is a critical piece of evidence for this hypothesis. However, only two studies have directly compared facial color preferences in two cultures. Both of those studies reported that White UK and Black African participants showed similar preferences for facial coloration. By contrast with the cross-cultural similarity reported in those studies, here we show cultural differences in the effects of facial coloration on Chinese and White UK participants' facial attractiveness judgments. While Chinese participants preferred faces with decreased yellowness to faces with increased yellowness, White UK participants preferred faces with increased yellowness to faces with decreased yellowness. Chinese participants also demonstrated weaker preferences for facial redness and stronger preferences for facial lightness than did White UK participants. These results suggest that preferences for facial coloration are not universal. 相似文献
992.
Rose Vanessa Bandeira Reidel Bernardo Melai Pier Luigi Cioni Luisa Pistelli 《Plant biosystems》2018,152(4):825-830
The volatiles emitted in vivo by different organs (leaf, bud flower, flower, green and red fruits) of Ziziphus jujuba were analysed using HS-SPME-GC/MS. A total of 144 compounds were identified corresponding to 94.6–99.4% of the whole aroma profile of jujube samples. The main constituents detected were (E, E)-α-farnesene, (E)-β-ocimene, perillene, γ-terpinene, cis-sabinene-hydrate, trans-sabinene-hydrate and 4-terpineol. The SPME analyses of the collected samples showed different patterns of emission and can contribute to understand their ecological interactions and fruit production management. 相似文献
993.
Closed‐reference metatranscriptomics enables in planta profiling of putative virulence activities in the grapevine trunk disease complex
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994.
Jennifer F. Knight Vanessa Y.C. Sung Elena Kuzmin Amber L. Couzens Danielle A. de Verteuil Colin D.H. Ratcliffe Paula P. Coelho Radia M. Johnson Payman Samavarchi-Tehrani Tina Gruosso Harvey W. Smith Wontae Lee Sadiq M. Saleh Dongmei Zuo Hong Zhao Marie-Christine Guiot Ryan R. Davis Jeffrey P. Gregg Morag Park 《Cell reports》2018,22(12):3191-3205
995.
Thayana Conceição Barbosa Bruno Almeida Lopes Caroline Barbieri Blunck Marcela Braga Mansur Adriana Vanessa Santini Deyl Mariana Emerenciano Maria S. Pombo-de-Oliveira 《BMC medical genomics》2018,11(1):122
Background
Chromosome translocations are a hallmark of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Additional genomic aberrations are also crucial in both BCP-ALL leukemogenesis and treatment management. Herein, we report the phenotypic and molecular cytogenetic characterization of an extremely rare case of BCP-ALL harboring two concomitant leukemia-associated chromosome translocations: t(1;19)(q23;q13.3) and t(9;17)(p13;q11.2). Of note, we described a new rearrangement between exon 6 of PAX5 and a 17q11.2 region, where intron 3 of SPECC1 is located. This rearrangement seems to disrupt PAX5 similarly to a PAX5 deletion. Furthermore, a distinct karyotype between diagnosis and relapse samples was observed, disclosing a complex clonal evolution during leukemia progression.Case presentation
A 16-year-old boy was admitted febrile with abdominal and joint pain. At clinical investigation, he presented with anemia, splenomegaly, low white blood cell count and 92% lymphoblast. He was diagnosed with pre-B ALL and treated according to high risk GBTLI-ALL2009. Twelve months after complete remission, he developed a relapse in consequence of a high central nervous system and bone marrow infiltration, and unfortunately died.Conclusions
To our knowledge, this is the first report of a rearrangement between PAX5 and SPECC1. The presence of TCF3-PBX1 and PAX5-rearrangement at diagnosis and relapse indicates that both might have participated in the malignant transformation disease maintenance and dismal outcome.996.
997.
998.
Vanessa Capone Emanuela Clemente Elena Restelli Antonella Di Campli Samantha Sperduti Francesca Ornaghi Laura Pietrangelo Feliciano Protasi Roberto Chiesa Michele Sallese 《生物化学与生物物理学报:疾病的分子基础》2018,1864(10):3164-3180
Loss-of-function mutations in the SIL1 gene are linked to Marinesco-Sjögren syndrome (MSS), a rare multisystem disease of infancy characterized by cerebellar and skeletal muscle degeneration. SIL1 is a ubiquitous adenine nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone BiP. The complexity of mechanisms by which loss of SIL1 causes MSS is not yet fully understood. We used HeLa cells to test the hypothesis that impaired protein folding in the ER due to loss of SIL1 could affect secretory trafficking, impairing the transport of cargoes essential for the function of MSS vulnerable cells. Immunofluorescence and ultrastructural analysis of SIL1-knocked-down cells detected ER chaperone aggregation, enlargement of the Golgi complex, increased autophagic vacuoles, and mitochondrial swelling. SIL1-interefered cells also had delayed ER-to-plasma membrane transport with retention of Na+/K+-ATPase and procollagen-I in the ER and Golgi, and increased apoptosis. The PERK pathway of the unfolded protein response was activated in SIL1-interfered cells, and the PERK inhibitor GSK2606414 attenuated the morphological and functional alterations of the secretory pathway, and significantly reduced cell death. These results indicate that loss of SIL1 is associated with alterations of secretory transport, and suggest that inhibiting PERK signalling may alleviate the cellular pathology of SIL1-related MSS. 相似文献
999.
1000.
Diego Henrique Mirandola Dias Vieira Vinícius Panciera Tagliavini Vanessa Doro Abdallah Rodney Kozlowiski de Azevedo 《Systematic parasitology》2018,95(2-3):309-318
A new species of myxozoan, Myxobolus imparfinis n. sp. is described based on material from the gills of Imparfinis mirini (Haseman) (Heptapteridae). Mature myxospores are round, measuring 7.1–8.4 (7.9 ± 0.3) μm in length, 4.5–6.2 (5.5 ± 0.5) μm in width and 3.1–4.2 (3.7 ± 0.3) μm in thickness. The polar capsules are of unequal size, the larger polar capsule measuring 3.4–4.5 (3.9 ± 0.3) μm in length and 1.4–2.0 (1.7 ± 0.1) μm in width and the smaller capsule measuring 3.1–3.8 (3.4 ± 0.2) μm in length and 1.2–1.8 (1.5 ± 0.2) μm in width. The polar filament presents 6–7 coils. Spores had a prevalence of infection of 75% (6/8). In histological analyses we detected the development site of spores in primary filaments, in afferent branchial artery, thus classifying the type of infection to the filamental type and vascular subtype. The phylogenetic analyses of a dataset including species Myxobolus Bütschli, 1882 and Henneguya Thélohan, 1892 from South America recovered M. imparfinis n. sp. as a sister species of Myxobolus flavus Carriero, Adriano, Silva, Ceccarelli & Maia, 2013. To our knowledge, this is the first record of a myxozoan species parasitising I. mirini. 相似文献