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排序方式: 共有179条查询结果,搜索用时 15 毫秒
161.
da Silva Ramos Rocha A Conceição FR Grassmann AA Lagranha VL Dellagostin OA 《Canadian journal of microbiology》2008,54(8):677-686
The B subunit of Escherichia coli heat-labile enterotoxin (LTB), a nontoxic molecule with potent biological properties, is a powerful mucosal and parenteral adjuvant that induces a strong immune response against co-administered or coupled antigens. In this paper, the effect of LTB on the humoral immune response to recombinant BCG (rBCG) vaccination was evaluated. Isogenic mice were immunized with rBCG expressing the R1 repeat region of the P97 adhesin of Mycoplasma hyopneumoniae alone (rBCG/R1) or fused to LTB (rBCG/LTBR1). Anti-R1 systemic antibody levels (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgA) were measured by ELISA using recombinant R1 as antigen. With the exception of IgM, LTB doubled the anti-R1 antibody levels in rBCG vaccination. The IgG1/IgG2a mean ratio showed that both rBCG/LTBR1 and rBCG/R1 induced a mixed Th1/Th2 immune response. Interestingly, anti-R1 serum IgA was induced only by rBCG/LTBR1. These results demonstrate that LTB has an adjuvant effect on the humoral immune response to recombinant antigens expressed in BCG. 相似文献
162.
Hauptmann Alexander v. Homeyer und E. Schütt 《Journal of Ornithology》1873,21(3):218-223
Ohne Zusammenfassung 相似文献
163.
One hundred cases of adult AML were classified cytomorphologically (FAB-classification) and cytochemically (Loeffler's classification). From this combined analysis it could be shown that some corrections have to be made in the FAB-classification; particularly groups M-1 and M-4 had to be reclassified. The authors, therefore, advocate that the final FAB-classification should be the result of cytomorphologic as well as cytochemical analysis. 相似文献
164.
Synthetic, low-molecular weight thrombin inhibitors may substitute for antithrombin III in inactivating thrombin in vitro and in vivo. They are superior to heparin as antithrombotic agents in antithrombin deficiency or consumption. Studies in experimental animals show the effectiveness of synthetic thrombin inhibitors in immunologic antithrombin depletion, thrombin-induced consumption and CCl4-induced liver failure. 相似文献
165.
B Kaiser J Hauptmann F Markwardt 《Folia haematologica (Leipzig, Germany : 1928)》1988,115(1-2):119-125
Antithrombotic, haemorrhagic and anticoagulant effects of unfractionated heparin (UH) and the low molecular weight heparin fragment KABI 2165 were studied in rats. In stasis-induced venous thrombosis of the jugular vein intravenous injection of both, UH and KABI 2165, either reduced significantly the size of thrombi or completely prevented thrombus formation in a dose-dependent manner. The dose of KABI 2165 required for prevention of thrombus formation showed a marked anticoagulant activity measured by APTT which was in the same range as that of the equieffective dose of UH. After administration of antithrombotically effective doses only UH caused a significant prolongation of bleeding time after standardized incision of the tail. KABI 2165 produced haemorrhagic effects at about 4-fold higher doses only than those required for the antithrombotic action. 相似文献
166.
167.
Comparison of different telepathology solutions for primary frozen section diagnostic. 总被引:1,自引:0,他引:1
P Hufnagl G Bayer P Oberbamscheidt K Wehrstedt H Guski S Hauptmann M Dietel 《Analytical cellular pathology》2000,21(3-4):161-167
In a retrospective study on a set of 125 cases we compared the following three telepathology solutions for primary frozen section diagnosis: ATM-TP (connection via ATM), TPS 1.0 (connection via LAN) and TELEMIC (connection via Internet), which represent different concepts of telepathological procedures. A set of 125 routine frozen sections (breast) was selected from the Charité cases of the year 1999. Four experienced pathologists diagnosed retrospectively all of these cases using the ATM-TP and TPS systems and 53 of them with the TELEMIC system. Using the ATM-TP we recorded no false positive (0%), 4 false negative (3.2%) and 4 deferred (3.2%) cases. Using the TPS we recorded no false positive (0%), 4 false negative (3.2%) and 4 deferred (3.2%) cases. Using the TELEMIC we recorded in 53 cases no false positive (0%), no false negative (0%) and 16 deferred (30.2%) cases. The average time of 2.2 minutes per case using ATM-TP is also short enough for routine frozen section diagnostic. This is also true for the TPS system with 7.2 minutes per case. 相似文献
168.
Valeska Vollrath Jose Chianale Sergio Gonzalez Ignacio Duarte Leonardo Andrade Luis Ibañez 《Virchows Archiv. B, Cell pathology including molecular pathology》1991,60(1):133-138
Overexpression of the Multiple Drug Resistance gene (MDR1) has been proposed as a major mechanism related to both intrinsic
and acquired resistance to chemotherapeutic agents. The gene product is a membrane protein (P-glycoprotein), that acts as
an energydependent drug efflux pump decreasing drug accumulation in resistant tumor cells. We have characterized MDR1 and
P-Glycoprotein expression in human gastric adenocarcinoma and in precursor lesions. MDR1 mRNAs, analyzed by dot-blot technique,
were detected in 9 of 10 non-tumoral gastric mucosae and in 8 of 10 gastric adenocarcinomas. Immunohistochemical analysis,
using the MRK16 monoclonal antibody, revealed heterogeneous expression of P-Glycoprotein in individual cells. The P-Glycoprotein
was found on the surface of cells of gastric areas with intestinal metaplasia subtype III. This type of intestinal metaplasia,
also called “colonic metaplasia”, has been strongly associated with a high risk for the development of gastric cancer. The
fact that the P-Glycoprotein was detected in this precursor lesion is consistent with the intestinal metaplasia dysplasia
and carcinoma sequence proposed in the histogenesis of this tumor. The finding that P-Glycoprotein was heterogeneously expressed
in malignant cells of some gastric adenocarcinomas also suggests that this transporter system probably contributes to primary
and secondary multidrug resistance in this neoplasm. 相似文献
169.
170.
H Minigo D Nemet A Planinc-Peraica V Bogdanic B Labar B Jaksic E Hauptmann 《Folia haematologica (Leipzig, Germany : 1928)》1990,117(1):135-140
Twenty-one newly diagnosed adult AML patients were treated with high dose Ara-C (HD-ARA-C) as a single induction treatment with the dose of 2 g/m2 q 12 hours x 12. Seventy-six percent (16/21) responded with complete remission. Three patients died in induction in pancytopenia, another one died on day 44 in CR due to bleeding of pulmonary aspergilloma. This treatment seems to be highly efficient for remission induction, but requires an adequate transfusion and other supportive measures. The overall toxicity was transient and seems acceptable. However, the remission duration is unacceptably short, the consolidation with the same treatment seems to be inadequate. More aggressive treatment in postinduction period seems to be warranted. 相似文献