A new genus and species of galeommatoid bivalve (Mollusca: Bivalvia: Montacutidae) from Kuwait Bay,Arabian Gulf

Larissamya comta gen. n., sp. n., is described from Kuwait Bay, northern Arabian Gulf. The hinge is identical to that seen in Kurtiella and Montacutona but the spined dorsal margin is unique. Anatomically Larissamya differs from Kurtiella in retaining both gill demibranchs and from both Kurtiella and Montacutona in having greatly unequal adductor muscles. Co-occurrence and density data suggest that L. comta may be associated with the ophuroid Amphiura fasciata.

http://www.zoobank.org/urn:lsid:zoobank.org:pub:ECCB79FC-6EB2-4693-B1D4A014CB17C6D8     

Structural and functional properties of inulinases: A review

The studies of structural and functional properties of inulinases and their molecular and supramolecular organization are crucial for understanding the functional mechanisms for key enzymes of polyfructans metabolism which demands special attention. This review addresses these issues with a focus to disagreement concerning supramolecular organization of inulinases, practical importance of different glycosylation degrees, and mechanism of splitting of glycosidic linkages, which occur in different organisms.     

Effect of Bacillus mucilaginosus biomass on the exocrine function of the pancreas in piglets]

The effect of mucous bacilli on the excretory activity of pancreas in pigs has been investigated. The use of biomass at doses of 0.1, 0.2 and 0.3 g/kg stimulates to a different extent the pancreatic exocrine function in pigs: the pancreatic juice volume increases, on the average, by 17-20% and the secretion of amylolytic, proteolytic and lipolytic enzymes of the pancreatic juice becomes 1.6-2.2, 1.5-1.8 and 1.4-1.7 times higher, respectively. The increased functional activity of pancreas indicates the high reserve secretory potential of the pancreatic secretory apparatus. When brought into action, this apparatus favours more complete segregation and absorption of food nutrients.     

Statilia maculata (Thunberg, 1784) – the first invasive praying mantis (Mantodea,Mantidae) in the fauna of Russia

Summary

Recent years have seen an increasing number of alien praying mantis species being introduced and establishing populations across Europe. Here we add to this count, reporting a stable and spreading population of an Asian species, Statilia maculata (Thunberg, 1784), in Krasnodar Krai of Southern Russia. This is the first introduced praying mantis species in the Russian fauna and the first representative of the genus Statilia Stål, 1877 in Europe. We review what is known about biology of this species and provide diagnostic characters to distinguish nymphs, adults and oothecae from native and introduced European species of praying mantis. Our attempts at captive breeding identify humidity as one of the most important factors limiting possible spread of S. maculata. Invasion to neighbouring territories and other countries with a humid subtropical climate remains a very real possibility with an unknown outcome for local ecosystems.     

A key metabolic integrator,coenzyme A,modulates the activity of peroxiredoxin 5 via covalent modification

Molecular and Cellular Biochemistry - Cisplatin has been extensively used as a chemotherapeutic agent since around 40 years, though its usage is limited due to severe adverse effects like...     

Inhibition of new vessel growth in mouse model of laser-induced choroidal neovascularization by adiponectin peptide II

We have investigated the effect of adiponectin (APN) peptide II on new vessel growth in mouse model of choroidal neovascularization (CNV) or wet type age-related macular degeneration (AMD). Mice were injected intraperitoneally with APN peptide II, control peptide, or PBS on day 1-7 or day 5-14. APN, AdipoR1, PCNA, and VEGF localization was investigated using confocal microscopy, immunohistochemistry, and RT-PCR. APN peptide II decreased the relative area of FITC-dextran perfused vessels by 4-fold, PCNA expression by 3-fold, and the number of PCNA stained HUVEC and MAVEC cells by 38 and 46%, respectively. We concluded that APN peptide II inhibits CNV size on days 7 and 14 by inhibiting the proliferation of endothelial cells in vivo and in vitro. APN peptide II may have therapeutic potential to inhibit CNV or wet AMD.     

Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease

BACKGROUNDMultipotent mesenchymal stromal cells (MSCs) are widely used in the clinic due to their unique properties, namely, their ability to differentiate in all mesenchymal directions and their immunomodulatory activity. Healthy donor MSCs were used to prevent the development of acute graft vs host disease (GVHD) after allogeneic bone marrow transplantation (allo-BMT). The administration of MSCs to patients was not always effective. The MSCs obtained from different donors have individual characteristics. The differences between MSC samples may affect their clinical efficacy.AIMTo study the differences between effective and ineffective MSCs.METHODSMSCs derived from the bone marrow of a hematopoietic stem cells donor were injected intravenously into allo-BMT recipients for GVHD prophylaxis at the moment of blood cell reconstitution. Aliquots of 52 MSC samples that were administered to patients were examined, and the same cells were cultured in the presence of peripheral blood mononuclear cells (PBMCs) from a third-party donor or treated with the pro-inflammatory cytokines IL-1β, IFN and TNF. Flow cytometry revealed the immunophenotype of the nontreated MSCs, the MSCs cocultured with PBMCs for 4 d and the MSCs exposed to cytokines. The proportions of CD25-, CD146-, CD69-, HLA-DR- and PD-1-positive CD4+ and CD8+ cells and the distribution of various effector and memory cell subpopulations in the PBMCs cocultured with the MSCs were also determined.RESULTSDifferences in the immunophenotypes of effective and ineffective MSCs were observed. In the effective samples, the mean fluorescence intensity (MFI) of HLA-ABC, HLA-DR, CD105, and CD146 was significantly higher. After MSCs were treated with IFN or cocultured with PBMCs, the HLA-ABC, HLA-DR, CD90 and CD54 MFI showed a stronger increase in the effective MSCs, which indicated an increase in the immunomodulatory activity of these cells. When PBMCs were cocultured with effective MSCs, the proportions of CD4+ and CD8+central memory cells significantly decreased, and the proportion of CD8+CD146+ lymphocytes increased more than in the subpopulations of lymphocytes cocultured with MSC samples that were ineffective in the prevention of GVHD; in addition, the proportion of CD8+effector memory lymphocytes decreased in the PBMCs cocultured with the effective MSC samples but increased in the PBMCs cocultured with the ineffective MSC samples. The proportion of CD4+CD146+ lymphocytes increased only when cocultured with the inefficient samples.CONCLUSIONFor the first time, differences were observed between MSC samples that were effective for GVHD prophylaxis and those that were ineffective. Thus, it was shown that the immunomodulatory activity of MSCs depends on the individual characteristics of the MSC population.