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161.
Ferrari G Pastorelli R Buchi F Spinelli E Gozzini A Bosi A Santini V 《Journal of proteome research》2007,6(1):367-375
Imatinib is the first molecular targeted therapy that has shown clinical success, but imatinib acquired resistance, although a rare event, is critical during the therapy of chronic myelogenous leukaemia (CML). With the aim of better understanding the molecular mechanisms accompanying acquisition of resistance to this drug, a comparative proteomic approach was undertaken on CML cell lines LAMA 84 S (imatinib sensitive) and LAMA 84 R (imatinib resistant). Forty-four differentially expressed proteins were identified and categorized into five main functional classes: (I) heat shock proteins and chaperones; (II) nucleic acid interacting proteins (binding/synthesis/stability); (III) structural proteins, (IV) cell signaling, and (V) metabolic enzymes. Several heat shock proteins known to complex Bcr-Abl were overexpressed in imatinib resistant cells, showing a possible involvement of these proteins in the mechanism of resistance. HnRNPs also resulted in being up-regulated in imatinib resistant cells. These proteins have been shown to be strongly and directly related to Bcr-Abl activity. To our knowledge, this is the first direct proteomic comparison of imatinib sensitive/resistant CML cell lines. 相似文献
162.
Randrianarison Rose Marie Lutz Meredith Torti Valeria Tan Chia Bonadonna Giovanna Randrianambinina Blanchard Rasoloharijaona Solofonirina Rabarison Harison Miaretsoa Longondraza Rarojoson Nianja Jemisa De Gregorio Chiara Valente Daria Gamba Marco Ratsimbazafy Jonah Giacoma Cristina 《International journal of primatology》2022,43(4):584-610
International Journal of Primatology - Deforestation around the world is a major threat to primates. Understanding primate species’ habitat and dietary requirements is critical in creating... 相似文献
163.
The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions 总被引:1,自引:0,他引:1
164.
María Sol Gaspe Yael Mariana Provecho Romina Valeria Piccinali Ricardo Esteban Gürtler/ 《Memórias do Instituto Oswaldo Cruz》2015,110(3):310-318
House re-invasion by native triatomines after insecticide-based control campaigns
represents a major threat for Chagas disease vector control. We conducted a
longitudinal intervention study in a rural section (Area III, 407 houses) of Pampa
del Indio, northeastern Argentina, and used wing geometric morphometry to compare
pre-spray and post-spray (re-infestant bugs) Triatoma infestans
populations. The community-wide spraying with pyrethroids reduced the prevalence of
house infestation by T. infestans from 31.9% to < 1% during a
four-year follow-up, unlike our previous studies in the neighbouring Area I. Two
groups of bug collection sites differing in wing shape variables before interventions
(including 221 adults from 11 domiciles) were used as a reference for assigning 44
post-spray adults. Wing shape variables from post-spray, high-density bug colonies
and pre-spray groups were significantly different, suggesting that re-infestant
insects had an external origin. Insects from one house differed strongly in wing
shape variables from all other specimens. A further comparison between insects from
both areas supported the existence of independent re-infestation processes within the
same district. These results point to local heterogeneities in house re-infestation
dynamics and emphasise the need to expand the geographic coverage of vector
surveillance and control operations to the affected region. 相似文献
165.
The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype
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Fabio Valenti Jessica Ibetti Yuko Komiya Melissa Baxter Anna Maria Lucchese Lauren Derstine Claudia Covaciu Valeria Rizzo Renza Vento Giuseppe Russo Marcella Macaluso Franco Cotelli Daniele Castiglia Cara J. Gottardi Raymond Habas Antonio Giordano Gianfranco Bellipanni 《Journal of cellular biochemistry》2015,116(3):418-430
166.
Mala Isrie Martin Breuss Guoling Tian Andi?Harley Hansen Francesca Cristofoli Jasmin Morandell Zachari?A. Kupchinsky Alejandro Sifrim Celia?Maria Rodriguez-Rodriguez Elena?Porta Dapena Kurston Doonanco Norma Leonard Faten Tinsa Stéphanie Moortgat Hakan Ulucan Erkan Koparir Ender Karaca Nicholas Katsanis Valeria Marton Joris?Robert Vermeesch Erica?E. Davis Nicholas?J. Cowan David?Anthony Keays Hilde Van?Esch 《American journal of human genetics》2015,97(6):790-800
Circumferential skin creases Kunze type (CSC-KT) is a specific congenital entity with an unknown genetic cause. The disease phenotype comprises characteristic circumferential skin creases accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features. Here, we report that mutations in either MAPRE2 or TUBB underlie the genetic origin of this syndrome. MAPRE2 encodes a member of the microtubule end-binding family of proteins that bind to the guanosine triphosphate cap at growing microtubule plus ends, and TUBB encodes a β-tubulin isotype that is expressed abundantly in the developing brain. Functional analyses of the TUBB mutants show multiple defects in the chaperone-dependent tubulin heterodimer folding and assembly pathway that leads to a compromised yield of native heterodimers. The TUBB mutations also have an impact on microtubule dynamics. For MAPRE2, we show that the mutations result in enhanced MAPRE2 binding to microtubules, implying an increased dwell time at microtubule plus ends. Further, in vivo analysis of MAPRE2 mutations in a zebrafish model of craniofacial development shows that the variants most likely perturb the patterning of branchial arches, either through excessive activity (under a recessive paradigm) or through haploinsufficiency (dominant de novo paradigm). Taken together, our data add CSC-KT to the growing list of tubulinopathies and highlight how multiple inheritance paradigms can affect dosage-sensitive biological systems so as to result in the same clinical defect. 相似文献
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170.
Juan Pablo Gomez-Escribano Jean Franco Castro Valeria Razmilic Govind Chandra Barbara Andrews Juan A. Asenjo Mervyn J. Bibb 《BMC genomics》2015,16(1)