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51.
Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin 下载免费PDF全文
Valentina De Lorenzi Gian Maria Sarra Ferraris Jeppe B Madsen Michela Lupia Peter A Andreasen Nicolai Sidenius 《EMBO reports》2016,17(7):982-998
Components of the plasminogen activation system including urokinase (uPA), its inhibitor (PAI‐1) and its cell surface receptor (uPAR) have been implicated in a wide variety of biological processes related to tissue homoeostasis. Firstly, the binding of uPA to uPAR favours extracellular proteolysis by enhancing cell surface plasminogen activation. Secondly, it promotes cell adhesion and signalling through binding of the provisional matrix protein vitronectin. We now report that uPA and plasmin induces a potent negative feedback on cell adhesion through specific cleavage of the RGD motif in vitronectin. Cleavage of vitronectin by uPA displays a remarkable receptor dependence and requires concomitant binding of both uPA and vitronectin to uPAR. Moreover, we show that PAI‐1 counteracts the negative feedback and behaves as a proteolysis‐triggered stabilizer of uPAR‐mediated cell adhesion to vitronectin. These findings identify a novel and highly specific function for the plasminogen activation system in the regulation of cell adhesion to vitronectin. The cleavage of vitronectin by uPA and plasmin results in the release of N‐terminal vitronectin fragments that can be detected in vivo, underscoring the potential physiological relevance of the process. 相似文献
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Giulia Schiroli Anastasia Conti Samuele Ferrari Lucrezia della Volpe Aurelien Jacob Luisa Albano Stefano Beretta Andrea Calabria Valentina Vavassori Patrizia Gasparini Eralda Salataj Delphine Ndiaye-Lobry Chiara Brombin Julie Chaumeil Eugenio Montini Ivan Merelli Pietro Genovese Luigi Naldini Raffaella Di Micco 《Cell Stem Cell》2019,24(4):551-565.e8
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Biodeterioration of crude oil and oil derived products: a review 总被引:2,自引:0,他引:2
Natalia A. Yemashova Valentina P. Murygina Dmitry V. Zhukov Arpenik A. Zakharyantz Marina A. Gladchenko Vasu Appanna Sergey V. Kalyuzhnyi 《Reviews in Environmental Science and Biotechnology》2007,6(4):315-337
Biodeterioration of crude oil and oil fuels is a serious economic and an environmental problem all over the world. It is impossible
to prevent penetration of microorganisms in oil and fuels both stored in tanks or in oilfields after drilling. Both aerobic
and anaerobic microorganisms tend to colonise oil pipelines and oil and fuel storage installations. Complex microbial communities
consisting of both hydrocarbon oxidizing microorganisms and bacteria using the metabolites of the former form an ecological
niche where they thrive. The accumulation of water at the bottom of storage tanks and in oil pipelines is a primary prerequisite
for development of microorganisms in fuels and oil and their subsequent biological fouling. Ability of microorganisms to grow
both in a water phase and on inter-phase of water/hydrocarbon as well as the generation of products of their metabolism worsen
the physical and chemical properties of oils and fuels. This activity also increases the amount of suspended solids, leads
to the formation of slimes and creates a variety of operational problems. Nowadays various test-systems are utilized for microbial
monitoring in crude oils and fuels; thus allowing an express determination of both the species and the quantities of microorganisms
present. To suppress microbial growth in oils and fuels, both physico-mechanical and chemical methods are applied. Among chemical
methods, the preference is given to substances such as biocides, additives, the anti-freezing agents etc that do not deteriorate
the quality of oil and fuels and are environmentally friendly. This review is devoted to the analysis of the present knowledge
in the field of microbial fouling of crude oils and oil products. The methods utilized for monitoring of microbial contamination
and prevention of their undesirable activities are also evaluated. The special focus is given to Russian scientific literature
devoted to crude oil and oil products biodeterioration. 相似文献
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