Charge trapping by solitions—A possible transport mechanism in macromolecular systems

Macromolecules and their aggregates possess polar modes which, when excited, cause deformations, which provoke in turn elastic restoring forces. Even the simplest of such models (involving polarization and elastic modes along a chain) admit localized excitations (solitons) endowed with a characteristic degree of stability; and these provide a mechanism for charge trapping which may be of importance in the understanding of the elusively high efficiency of charge transfer over macroscopic distances evidently involved in various biomolecular processes.     

Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening

With the aim to discover orally active small molecules that stimulate glucose uptake, high throughput screening of a library of 5000 drug-like compounds was conducted in differentiated skeletal muscle cells in presence of insulin. N-Substituted phthalazinone acetamide was identified as a potential glucose uptake modulator. Several novel derivatives were synthesized to establish structure activity relationships. Identified lead thiazolyl-phthalazinone acetamide (7114863) increased glucose uptake (EC₅₀ of 0.07 ± 0.02 μM) in differentiated skeletal muscle cells in presence of insulin. Furthermore, 7114863 was superior to rosiglitazone under similar experimental conditions without inducing PPAR-γ agonist activity thus making it a very interesting scaffold.     

The phytochemistry of the annonaceae

Both alkaloidal and non-alkaloidal compounds so farsolated from Annonaceous plants are reviewed. 319 secondary products have been reported from 150 spe