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排序方式: 共有152条查询结果,搜索用时 4 毫秒
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Eugene V. Tolchkov Irina A. Kramerova Sergei A. Lavrov Vanya I. Rasheva Silvia Bonaccorsi Vladimir E. Alatortsev Vladimir A. Gvozdev 《Chromosoma》1997,106(8):520-525
In(1LR)pn2a is a pericentric inversion with a euchromatic breakpoint in the 2E polytene region and a heterochromatic breakpoint in the
right arm of the X chromosome. It is associated with position-effect variegation (PEV) of the pn, wapl, Pgd and other vital loci of the 2E region, which are relocated near the bulk of the X heterochromatin. Cytological analysis showed that the rearrangement brings the 1A–2E euchromatic segment directly into contact
with a major portion of the h34 block, a heterochromatic region that is positively stained by the N-banding technique and
contains the AAGAG satellite sequences. Molecular cloning revealed the presence of a new junction between euchromatin and
AAGAG satellite sequences and demonstrated that the euchromatic breakpoint of In(1LR)pn2a lies in the vinculin gene. In the X ray-induced secondary rearrangement In(1LR)r30, consisting of a pericentric inversion superimposed on In(1LR)pn2a, the h34 material remains associated with the 2E region but is separated from the rest of the X heterochromatin. In this case, the pn, wapl and Pgd loci no longer variegate, suggesting that the satellite-containing h34 region is not able per se to induce detectable PEV
on the adjacent euchromatic genes.
Received in revised form: 15 June 1997 / Accepted: 16 September 1997 相似文献
64.
Cytoplasmic Dynein Intermediate-Chain Isoforms with Different Targeting Properties Created by Tissue-Specific Alternative Splicing 总被引:6,自引:0,他引:6 下载免费PDF全文
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Concerted transpositions of mobile genetic elements coupled with fitness changes in Drosophila melanogaster 总被引:3,自引:0,他引:3
Pasyukova EG; Belyaeva ES; Kogan GL; Kaidanov LZ; Gvozdev VA 《Molecular biology and evolution》1986,3(4):299-312
In an inbred low-activity (LA) strain of Drosophila melanogaster with a low
level of fitness and a complex of inadaptive characters, in situ
hybridization reveals an invariant pattern of distribution of three
copia-like elements (mdg-1, mdg-3, and copia). Rare, spontaneous, multiple
transpositions of mobile elements in the LA strain were shown to be coupled
with a drastic increase of fitness. A changed pattern of various types of
mobile elements was also observed on selecting the LA strain for higher
fitness. High-fitness strains show transpositions of mobile elements to
definite chromosomal sites ("hot spots"). Concerted changes in the location
of three different mobile elements were found to be coupled with an
increase of fitness. The mdg-1 distribution patterns were also examined in
two low-fitness strains independently selected from the high-fitness ones.
Fitness decrease was accompanied by mdg-1 excision from the hot spots of
their location usually detected in the high-fitness strains. The results
suggest the existence of a system of adaptive transpositions of mobile
elements that takes part in fitness control.
相似文献
67.
Yuriy A. Abramov Aleksei S. Shatskikh Oksana G. Maksimenko Silvia Bonaccorsi Vladimir A. Gvozdev Sergey A. Lavrov 《Genetics》2016,202(1):93-106
Position-effect variegation (PEV) is the epigenetic disruption of gene expression near the de novo–formed euchromatin-heterochromatin border. Heterochromatic cis-inactivation may be accompanied by the trans-inactivation of genes on a normal homologous chromosome in trans-heterozygous combination with a PEV-inducing rearrangement. We characterize a new genetic system, inversion In(2)A4, demonstrating cis-acting PEV as well as trans-inactivation of the reporter transgenes on the homologous nonrearranged chromosome. The cis-effect of heterochromatin in the inversion results not only in repression but also in activation of genes, and it varies at different developmental stages. While cis-actions affect only a few juxtaposed genes, trans-inactivation is observed in a 500-kb region and demonstrates а nonuniform pattern of repression with intermingled regions where no transgene repression occurs. There is no repression around the histone gene cluster and in some other euchromatic sites. trans-Inactivation is accompanied by dragging of euchromatic regions into the heterochromatic compartment, but the histone gene cluster, located in the middle of the trans-inactivated region, was shown to be evicted from the heterochromatin. We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. 相似文献
68.
M D Balakireva Shevelyov YuYa D I Nurminsky K J Livak V A Gvozdev 《Nucleic acids research》1992,20(14):3731-3736
Expression of the X-linked repeated Stellate (Ste) genes, which code for a protein with 38% similarity to the beta-subunit of casein kinase II, is suppressed by the Su(Ste) locus on the Y chromosome. The structure and evolution of the Y-linked repeats in the region of the Su(Ste) locus were studied. The 2800 bp repeats consist of three main elements: the region of homology to the Ste genes, an adjacent AT-rich, Y-specific segment, and mobile element 1360 inserted in the Ste sequence. Amplification of repeats was followed by point mutations, deletions, and insertions of mobile elements. DNA sequencing shows that these repeats may be considered as Ste pseudogenes or as damaged variants of a putative gene(s) encoding a protein quite different from the Ste protein as a result of an alternative splicing pattern. A comparison of 5 variants of the Y-Su(Ste) repeats shows a number of recombination events between amplified and diverged sequences that could be due to either multiple unequal mitotic sister-chromatid exchanges or to gene conversion. It is a first demonstration on a molecular level of these processes occurring in heterochromatic non-rDNA tandemly organized sequences in an eukaryotic genome. 相似文献
69.
Vasil'ev VI Tikhonova TV Gvozdev RI Tukhvatullin IA Popov VO 《Biochemistry. Biokhimii?a》2006,71(12):1329-1335
The hydroxylase component of membrane-bound (particulate) methane monooxygenase (pMMO) from Methylococcus capsulatus strain M was isolated and purified to homogeneity. The pMMO molecule comprises three subunits of molecular masses 47, 26, and 23 kD and contains three copper atoms and one iron atom. In solution the protein exists as a stable oligomer of 660 kD with possible subunit composition (alpha beta gamma)6. Mass spectroscopy shows high homology of the purified protein with methane monooxygenase from Methylococcus capsulatus strain Bath. Pilot screening of crystallization conditions has been carried out. 相似文献
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