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T. B. Lapirova V. R. Mikryakova A. S. Mavrin G. A. Yinogradova 《Journal of Evolutionary Biochemistry and Physiology》2000,36(1):47-51
The paper presents data on a change in lysozyme content in tissues of spleen, liver and heart in fry of the Lena River sturgeon
exposed to the presence of sublethal concentrations of Hg2+, Cd2+, and Cu2+ under conditions of chronic experiment. It has been shown that the lysozyme content in fish tissues varies and has a phasic
character. The amplitude of fluctuations of this parameter depends on the moment of sampling, nature of the toxicant, and
structural-functional organization of the studied organs. 相似文献
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Subsequent to observations that pulmonary responses to antigen challenge are of different magnitudes in sensitized rats that are anesthetized with different drugs, we conducted studies to test whether the alterations in responses were due to changes in airway responsiveness to cholinergic or serotonergic challenge, opioid-receptor mediated events, or changes in mast cell mediator release. Immunoglobulin E-sensitized rats anesthetized with ketamine/urethan had larger changes in lung resistance and plasma histamine after pulmonary antigen challenge compared with rats anesthetized with fentanyl-droperidol. Blockade of opioid receptors with naloxone did not affect the responses. In unsensitized rats, airway responses to aerosolized methacholine were similar for the two anesthetics, indicating unchanged smooth muscle responsiveness; however, airway responses to intravenous serotonin were enhanced by ketamine and ablated by droperidol. We conclude that ketamine- and droperidol-induced alterations of pulmonary allergic responses are due to changes in sensitivity to serotonin and in mast cell mediator release. We speculate that mast cell mediator release may be modulated by a serotonin receptor-linked mechanism. 相似文献
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Metabolic pathways involved in the oxidation of isopropanol into acetone by the intact rat 总被引:3,自引:0,他引:3
Isopropanol administered in a large (6 g/kg, orally) as well as in a lower dose (1 g/kg, I.P.) is slowly oxidized into acetone by the intact rat. Using two inhibitors, 3 amino-1,2,4-triazole and pyrazole, investigations on the hepatic enzymatic system involved in the oxidation of isopropanol show that catalase does not play an important part in this pathway, contrary to alcohol dehydrogenase which is the major enzyme responsible for this oxidation. Although isopropanol oxidation is mainly catalysed in the liver through alcohol dehydrogenase, no alteration of the hepatic extramitochondrial redox state occurs after the administration of a large as well as of a lower dose of isopropanol. From these experiments it may be concluded that alterations of the liver NAD+/NADH ratio, which seem to play an important part in the ethanol induced fatty liver, are not involved in the isopropanol induced one. 相似文献