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651.
Esaki Muthu Shankar Ramachandran Vignesh Kailapuri Gangatharan Murugavel Pachamuthu Balakrishnan Esakimuthu Ponmalar Usha Anand Rao Vijayakumar Velu & Suniti Solomon 《FEMS immunology and medical microbiology》2009,57(2):93-103
Opportunistic infections (OIs) are the leading cause of mortality and morbidity among HIV-positive subjects. The breadth of reports of the rare occurrence of OIs in HIV/AIDS has been increasing over the years and more recent studies have outlined the changing trends in the emergence of newer pathogens. Recent reports of the association of certain protozoans that normally do not infect sites other than their normal sites of localization have generated huge interest among scientists. The complete depression of the immune system, followed by the onset of OIs, especially due to protozoans, i.e. toxoplasmosis, isosporiasis, leishmaniasis, cyclosporosis, microsporidiosis and cryptosporidiosis, is not uncommon in AIDS. The immunologic and pathologic basis behind the susceptibility of immunodepressed individuals to these 'non-site-specific parasites' is likely to have a huge impact on HIV disease progression. Certain possible shortcomings in the immunologic armory of immunodeficient subjects, their failure to contain the establishment of these 'uncommon' agents in the human host and their significance in HIV disease progression are discussed. 相似文献
652.
Usha Natraj K. S. N. Iyer Vijaya Raghavan Smita Mahale Jacintha Pereira 《Journal of biosciences》1990,15(4):341-350
The antigenecity of tryptic fragments of reduced and carboxymethylated chicken riboflavin carrier protein were studied. The
tryptic sites of the native riboflavin carrier protein bound to riboflavin were inaccessible. The molecular weight and the
elution profile on high performance liquid chromatography (TSK 545 DEAE) were unaltered at an enzyme to substrate ratio of
1:31. However, carboxymethylated riboflavin carrier protein could be cleaved into 3 or 4 fragments at an enzyme to substrate
ratio of 1:250 or 1:125. Chromatographic separation of the tryptic fragments on high pressure liquid chromatography (TSK 545
DEAE) revealed the presence of two fragments with different elution profiles but similar molecular weight 26 ±2 kDa. Only
one fragment (associated with peak 2) had the ability to displace chicken riboflavin carrier protein in an homologous chicken
riboflavin carrier protein radioimmunoassay. Thus, carboxymethylated ribotlavin carrier protein which does not compete with
chicken riboflavin carrier protein in the radioimmunoassay, on mild trypsinization generates a fragment which interacts with
chicken riboflavin carrier protein in radioimmunoassay. 相似文献