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121.
On the kinetics and optimal specificity of cytotoxic reactions mediated by T-lymphocyte clones 总被引:1,自引:0,他引:1
René Lefever Jacques Hiernaux Jacques Urbain Patricia Meyers 《Bulletin of mathematical biology》1992,54(5):839-873
Using the chromium release assay and the single cell assay in agarose, we study the cytotoxic reaction of the MHC-restricted
T lymphocyte clones P89:15 and P1:3, which recognize distinct but specific tumour antigens on the surface of syngeneic P815
mastocytoma cells. We propose a mathematical model which describes these experiments, accounts for the strongly non-Michaelian
behaviour of the reaction and permits us to estimate the kinetic parameters characterizing effector-target conjugation and
lethal hit delivery. The results show that the binding and lytic activity of effector cells is modulated by the number of
targets bound to them. The binding of a second target by an effector having already a target bound is facilitated; on the
other hand, an effector having bound two targets delivers a lethal hit more slowly than one with a single target bound. We
investigate the role of these kinetic properties in the competition between the process of tumour progression due to cancer
cell replication and the process of tumour regression due to T lymphocyte cytotoxic activity. For both clones, we estimate
the effector-target ratio beyond which rejection prevails. This ratio is nine times larger for P1:3 than for P89:15. Furthermore,
our analysis suggests that there exists an optimal specificity minimizing this ratio. Deviations from this optimum, be it
in the sense of an increase or decrease of specificity, tendsto stabilize the tumoural state: a situation which in the broader context of the immune response evolution and regulation can be viewed
as animmune response dilemma. 相似文献
122.
The hyperbenthic fauna of the subtidal channels of the Eems (N. Netherlands), Westerschelde (S.W. Netherlands), and Gironde (S.W. France) estuaries was sampled within a 15-day period in summer 1991. In each estuary, quantitative samples were taken at regularly spaced stations covering the entire salinity gradient from marine conditions at the mouth to nearly freshwater conditions upstream. The diversity of the samples and the distribution of the species along the main estuarine gradients were assessed. Hyperbenthic communities were identified using different multivariate statistical techniques. The species composition and the density and biomass of the dominant species of each community were compared among communities. 相似文献
123.
Prof. Pierre Urbain 《International journal of biometeorology》1958,2(1):406-422
Sans résumé
Directeur de Laboratoire à l'Institut National d'Hydrologie et de Climatologie, Directeur du Centre de Recherches Climatologiques
de PAU. 相似文献
124.
125.