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31.
Thomas John Bender Matthew E. Wise Okey Utah Anne C. Moorman Umid Sharapov Jan Drobeniuc Yury Khudyakov Marielle Fricchione Mary Beth White-Comstock Nicola D. Thompson Priti R. Patel 《PloS one》2012,7(12)
Introduction
In January 2010, the Virginia Department of Health received reports of 2 hepatitis B virus (HBV) infections (1 acute, 1 chronic) among residents of a single assisted living facility (ALF). Both infected residents had diabetes and received assisted monitoring of blood glucose (AMBG) at the facility. An investigation was initiated in response.Objective
To determine the extent and mechanism of HBV transmission among ALF residents.Design
Retrospective cohort study.Setting
An ALF that primarily housed residents with neuropsychiatric disorders in 2 adjacent buildings in Virginia.Participants
Residents of the facility as of March 2010.Measurements
HBV serologic testing, relevant medical history, and HBV genome sequences. Risk ratios (RR) and 95% confidence intervals (CIs) were used to identify risk factors for HBV infection.Results
HBV serologic status was determined for 126 (91%) of 139 residents. Among 88 susceptible residents, 14 became acutely infected (attack rate, 16%), and 74 remained uninfected. Acute HBV infection developed among 12 (92%) of 13 residents who received AMBG, compared with 2 (3%) of 75 residents who did not (RR = 35; 95% CI, 8.7, 137). Identified infection control breaches during AMBG included shared use of fingerstick devices for multiple residents. HBV genome sequencing demonstrated 2 building-specific phylogenetic infection clusters, each having 99.8–100% sequence identity.Limitations
Transfer of residents out of the facility prior to our investigation might have contributed to an underestimate of cases. Resident interviews provided insufficient information to fully assess behavioral risk factors for HBV infection.Conclusions
Failure to adhere to safe practices during AMBG resulted in a large HBV outbreak. Protection of a growing and vulnerable ALF population requires improved training of staff and routine facility licensing inspections that scrutinize infection control practices. 相似文献32.
Sharapov Mars G. Gudkov Sergey V. Lankin Vadim Z. Novoselov Vladimir I. 《Biochemistry. Biokhimii?a》2021,86(11):1418-1433
Biochemistry (Moscow) - In this review, we discuss the pathogenesis of some socially significant diseases associated with the development of oxidative stress, such as atherosclerosis, diabetes, and... 相似文献
33.
K. N. Belosludtsev N. V. Belosludtseva K. S. Tenkov V. A. Sharapov E. A. Kosareva M. V. Dubinin 《Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology》2018,12(2):121-127
The effect of the lipophilic penetrating cation dequalinium on rat liver mitochondria was studied. It was found that dequalinium dose-dependently inhibits the respiration rate of rat liver mitochondria in ADP-stimulated (V3) and DNP-stimulated (uncoupled) states. This can be due to the fact that dequalinium is a potent inhibitor of complex III of the mitochondrial respiratory chain. It was shown that dequalinium induces a high-amplitude swelling of rat liver mitochondria. The dequalinium-induced swelling of the organelles depends on the presence of inorganic phosphate in the incubation medium: in the absence of phosphate or in the presence of the phosphate carrier inhibitor mersalyl in the phosphate-containing medium, no swelling of the mitochondria was observed. At low concentrations of dequalinium (≤10 μM), this swelling is inhibited by cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. At the same time, at high concentrations of dequalinium (>10 μM), cyclosporin A becomes ineffective. It was found that in the presence of dequalinium the rate of the H2O2 production increased in rat liver mitochondria. Possible mechanisms of toxic effect of dequalinium chloride are discussed. 相似文献
34.
O R Grek Iu I Borodin V I Sharapov A A Zykov T A Rybakova 《Biulleten' eksperimental'no? biologii i meditsiny》1988,106(7):34-37
The experiments on rats have shown that coronary artery ligation reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine-N-demethylation and aniline-p-hydroxylation disturbances that persist throughout a 3-week period of myocardial infarction. The investigation of spontaneous lipid peroxidation of microsomal membranes in myocardial infarction has shown that concentration of malonic dialdehyde in microsomal fraction significantly increased by the 7th day after coronary artery ligation, as compared to sham-operated rats. 相似文献
35.
36.
A. N. Sharapov V. N. Bezobrazova S. B. Dogadkina G. V. Kmit’ L. V. Rubleva 《Human physiology》2009,35(6):722-729
A complex study of the functional state of the cardiovascular system of seven- to ten-year-old children with different types
of autonomic nervous regulation of the heart rate was performed. It was found that the autonomic nervous system strongly affects
the adaptive capacity of the body, bioelectrical processes in the myocardium, the duration of cardiac-cycle phases, the pulse
volume, and the tone of large and small cerebral vessels. 相似文献
37.
Influence of animal hibernation on the development of mycoses 总被引:1,自引:0,他引:1
V. M. Sharapov 《Mycopathologia》1984,84(2-3):77-80
The development of adiaspiromycosis and trichophytosis depending upon the state of activity of redcheeked squirrels is described. The conidia of Chrysosporium (Emmonsia) parvum var. crescens, are not transformed into adiaspores when injected into hibernating animals. During the hibernation period of four months, most of the conidia die. After awakening, the remaining viable conidia are transformed into adiaspores. During hibernation the squirrels, which had been infected with Trichophyton mentagrophytes var. granulosum, developed a symptom-free infection. 相似文献
38.
39.
T. S. Frolova S. Z. Sharapov O. I. Sinitsyna T. G. Tolstikova I. A. Grigoriev S. V. Morozov Y. V. Yushkova 《Russian Journal of Bioorganic Chemistry》2018,44(3):330-336
Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments. 相似文献
40.
M. G. Sharapov A. E. Gordeeva R. G. Goncharov I. V. Tikhonova V. K. Ravin A. A. Temnov E. E. Fesenko V. I. Novoselov 《Biophysics》2017,62(6):998-1008
Oxidative stress is the main component of pathogenesis in ischemia–reperfusion injury. The administration of exogenous antioxidants suppresses oxidative stress and may decrease the severity of ischemia–reperfusion injury. The intestine is one of the most sensitive organs to the effect of ischemia–reperfusion. A rat model of a small intestine ischemia–reperfusion injury, based on occlusion of the superior mesenteric artery, was used in this work. Recombinant peroxiredoxin 6, a representative of an ancient family of peroxidases that are able to neutralize a broad range of both organic and inorganic peroxides, was used as an exogenous antioxidant. The intravenous administration of the exogenous peroxiredoxin 6 prior to ischemia–reperfusion minimizes tissue injury and reduces apoptotic cell death in the intestine and the mesenteric vessels. The impact of the exogenous peroxiredoxin 6 upon the NO level elevation in animal blood has been shown to be correlated with the enhanced inducible NO synthase expression. Thus, the use of exogenous peroxiredoxin 6 in ischemia–reperfusion injury of the intestine and the mesenteric vessels promotes normalization of the tissue redox homeostasis, structure protection, and restoration of the microvasculature. 相似文献