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461.
Daniela Montorio Gilda Cennamo Feliciana Menna Piero Donna Pasquale Napolitano Maria Angelica Breve Ugo Fiore Giovanni Cennamo Nicola Rosa 《Journal of biophotonics》2020,13(10)
The aim of this study is to evaluate corneal epithelial thickness (CET), corneal densitometry (CD) in 84 myopic eyes (57 patients) more than 22 years after photorefractive keratectomy, using anterior segment‐optical coherence tomography (AS‐OCT) and Scheimpflug imaging system. The CET was significantly higher in all operated eyes than in unoperated eyes in central sector. A statistically significant increase in CD in corneal anterior layer of central sector was shown in groups of operated eyes with greater ablation depth respect to unoperated eyes. While there was no significant difference in CD between the operated eyes groups with lower ablation depth and unoperated eyes. A significant trend toward higher values in anterior CD with deeper ablations in central sector was found. These noninvasive imaging techniques allow to better understand the corneal remodeling process after photoablation and to monitor the patients over time. 相似文献
462.
A. Savoia Maria Rosaria Piemontese Maria Savino Adriana Zatterale J. Pronk F. Arwert Hans Joenje Ugo Ramenghi Franca Dagna-Bricarelli Bruno Dallapiccola Leopoldo Zelante 《Human genetics》1996,99(1):93-97
Fanconi anaemia (FA) is an autosomal recessive disease characterised by genetic heterogeneity, with at least five complementation
groups (FA-A to FA-E). The FAC gene has been cloned and localised to 9q22.3. The most frequent defective gene, FAA, was recently
mapped to chromosome 16q24.3, in a region of 10 cM between D16S498 and the telomere. Eleven FA-A and 16 unclassified Italian
families were analysed by microsatellite markers. To define the localisation of the FAA locus further, microsatellites were
analysed at 16q24. All the families were consistent with linkage, the highest lod score being observed with D16S1320. Evidence
for common haplotypes was obtained in two genetic isolates from the Brenta basin and the Naples region. Autozygosity mapping
and haplotype analysis suggest that the FAA locus is distal to D16S305.
Received: 29 July 1996 相似文献
463.
Ugo Chiacchio Vincenzina Barbera Roberta Bonfanti Gian Luigi Broggini Agata Campisi Silvia Gazzola Rosalba Parenti Giovanni Romeo 《Bioorganic & medicinal chemistry》2013,21(18):5748-5753
A series of 1,7,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyrazin-6(5H)-ones has been synthesized by an intramolecular, palladium(II) catalyzed, aminooxygenation of alkenyl ureas, readily available from glycine allylamides as starting materials. Biological tests showed that the obtained compounds are endowed with an interesting antitumoral activity against two human thyroid cancer cell lines, namely FTC-133 and 8305C, by promoting the apoptotic pathway and DNA fragmentation. 相似文献
464.
465.
Murray Goodman Alvin Steinfeld Alan Tonelli Ugo Lepore Manlio Palumbo Bernard Donzel 《Bioorganic chemistry》1974,3(2):184-203
The synthesis of the cyclo-hexadepsipeptide [l-valyl-d-hexahydromandelyl]3 is described. Examination of this macrocyclic compound by 220-MHz nuclear magnetic resonance spectroscopy shows that symmetrical conformations are stabilized in strongly polar solvents (trifluoroacetic acid, acetonitrile), whereas asymmetric conformations are preferred in nonpolar or slightly polar media such as carbon tetrachloride, chloroform, cyclohexane, and benzene.From analysis of the temperature dependence of the chemical shift and of the coupling constants, together with conformational energy calculations, a model is proposed for the preferred conformation of this molecule in nonpolar solvents. 相似文献
466.
Mouse peritoneal macrophages exposed to the RNA from the spleens of mice infected with Trypanosoma cruzi (iRNA) exhibit enhanced resistance to this parasite. The poly(A)-containing iRNA was found to be the active fraction. No such activity was observed in macrophages incubated with RNA from normal mice (nRNA) or with synthetic poly A. 相似文献