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R Tuttle J V Basmajian E Regenos G Shine 《American journal of physical anthropology》1972,37(2):255-265
Preliminary results of electromyographic (EMG) studies on the forearm of a gorilla provisionally support the hypothesis that special closepacked positioning mechanisms may characterize the wrist and metacarpophalangeal joints II–V in extant knuckle-walkers (chimpanzees and gorillas). We recommend that once the bony features, related to these close-packed positions are clearly identified, they may be employed strategically to discern evidence of a knuckle-walking heritage in the hands of extant hominoids, including man, and to trace the history of knuckle-walking in available fossils. This report contains results of the first successful employment of indwelling fine-wire electrode techniques to elucidate problems on the functional and evolutionary biology of great apes. 相似文献
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The kinetics of the effects of inductive photomorphogenically active light on etiolated peas have been studied by means of time-lapse photography. The effects noted include: (1) A light-induced decrease in the rate of stem elongation, beginning about 6 hr after the light treatment, and ending about 18 hr later. (2) A light-induced opening of the apical hook, beginning ca. 2–5 hr after light treatment, and reaching its peak rate ca. 6 hr later. (3) A light-stimulated circumnutation, starting usually about 15–22 hr after the light, and resulting in a decreased period of oscillation (from ca. 86 to ca. 76 min) and an increased amplitude (from 15° total angular displacement to about 40°). (4) A promotion of terminal bud growth, known from previous work to start at about 4 hr after irradiation and to reach a peak about 12 hr later. (5) A “bobbing” movement of the apex, apparently involving reversible hook and stem oscillations, which appears to be of endogenous origin and insensitive to light. These data furnish a kinetic background against which proposed biochemical mechanisms of de-etiolation can be assessed. 相似文献
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Andrea S. Grunst Melissa L. Grunst Rusty A. Gonser Elaina M. Tuttle 《Journal of evolutionary biology》2019,32(2):134-143
A central objective of evolutionary biology is understanding variation in life‐history trajectories and the rate of aging, or senescence. Senescence can be affected by trade‐offs and behavioural strategies in adults but may also be affected by developmental stress. Developmental stress can accelerate telomere degradation, with long‐term longevity and fitness consequences. Little is known regarding whether variation in developmental stress and telomere dynamics contributes to patterns of senescence during adulthood. We investigated this question in the dimorphic white‐throated sparrow (Zonotrichia albicollis), a species in which adults of the two morphs exhibit established differences in behavioural strategy and patterns of senescence, and also evaluated the relationship between oxidative stress and telomere length. Tan morph females, which exhibit high levels of unassisted parental care, display faster reproductive senescence than white females, and faster actuarial senescence than all of the other morph–sex classes. We hypothesized that high oxidative stress and telomere attrition in tan female nestlings could contribute to this pattern, since tan females are small and potentially at a competitive disadvantage even as nestlings. Nestlings that were smaller than nest mates had higher oxidative stress, and nestlings with high oxidative stress and fast growth rates displayed shorter telomeres. However, we found no consistent morph–sex differences in oxidative stress or telomere length. Results suggest that oxidative stress and fast growth contribute to developmental telomere attrition, with potential ramifications for adults, but that developmental oxidative stress and telomere dynamics do not account for morph–sex differences in senescence during adulthood. 相似文献
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Tuttle RL Bothos J Summers MK Luca FC Halazonetis TD 《Molecular cancer research : MCR》2007,5(12):1304-1311
A molecular pathway homologous to the S. cerevisiae mitotic exit network (MEN) and S. pombe septation initiation network has recently been described in higher eukaryotes and involves the tumor suppressor kinase LATS1 and its subunit MOB1A. The yeast MEN/septation initiation network pathways are regulated by the ubiquitin ligase defective in mitotic arrest 1 (Dma1p), a checkpoint protein that helps maintain prometaphase arrest when cells are exposed to microtubule poisons. We identified here the RING domain protein ring finger 8 (RNF8) as the human orthologue of the yeast protein Dma1p. Like its yeast counterparts, human DMA1/RNF8 localized at the midbody and its depletion by siRNA compromised mitotic arrest of nocodazole-treated cells in a manner dependent on the MEN. Depletion of MAD2, a spindle checkpoint protein, also compromised mitotic arrest, but in a MEN-independent manner. Thus, two distinct checkpoint pathways maintain mitotic arrest in cells exposed to microtubule poisons. 相似文献