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51.
Abdullah Al Emran Hsin‐Yi Tseng Mikaela C. Coleman Jessamy Tiffen Stuart Cook Helen M. McGuire Stuart Gallagher Carl Feng Peter Hersey 《Pigment cell & melanoma research》2020,33(5):660-670
Melanoma, as for many other cancers, undergoes a selection process during progression that limits many innate and adaptive tumor control mechanisms. Immunotherapy with immune checkpoint blockade overcomes one of the escape mechanisms but if the tumor is not eliminated other escape mechanisms evolve that require new approaches for tumor control. Some of the innate mechanisms that have evolved against infections with microorganisms and viruses are proving to be active against cancer cells but require better understanding of how they are activated and what inhibitory mechanisms may need to be targeted. This is particularly so for inflammasomes which have evolved against many different organisms and which recruit a number of cytotoxic mechanisms that remain poorly understood. Equally important is understanding of where these mechanisms will fit into existing treatment strategies and whether existing strategies already involve the innate killing mechanisms. 相似文献
52.
Noura Hamed Khalifa Al Shaqsi Horiya Ali Said Al Hoqani Mohammad Amzad Hossain Mohammed Abdullah Al Sibani 《Biochemistry and Biophysics Reports》2020
Chitin is an organic polymer and it is the most frequent marine natural polysaccharide after cellulose. The main natural sources of chitin are exoskeletons of insects, mollusks, the cell walls of certain fungi and crustaceans such as crabs, shrimps and lobsters. The waste of these marine exoskeletons are pollutant for the environment, but these waste raw materials could be useful for production of commercial products like chitin. Chitin is an important raw material used for water treatment, agricultural, biomedical, biotechnological purposes, food and paper industry and cosmetics. Based on the variety of importance, the present targets of this study are to optimize the demineralization process for the removal of calcium and phosphate contents from the waste of Portunidae segnis (P. segnis) by using acid at ambient temperature and to characterize the isolated demineralized sample as well as the percentage of remaining calcium and phosphorus contents by using Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). The prepared waste carbs coarse powder samples of P. segnis were demineralized with seven different concentrations of hydrochloric acid at ambient temperature for 1 h. All the demineralization samples by the different concentrations were analyzed by using sensitive ICP-OES. The results based on ICP-OES showed that among the seven different concentrations used in the demineralization process for the isolation of chitin, the best was 2 M of HCl concentration for the production of chitin. The results also showed that the optimized concentration 2 M HCl gave the minimum concentration of calcium and phosphorus compared to other concentrations applied in this experiment. In conclusion, the optimized concentration for demineralization process could be used commercially for the isolation or commercial production of chitin for agricultural, biomedical and biotechnological purposes. 相似文献
53.
Molecular Biology Reports - Alzheimer’s disease (AD) is a neurodegenerative old age disease that is complex, multifactorial, unalterable, and progressive in nature. The currently approved... 相似文献
54.
Chunmei Li Eliane Beauregard-Lacroix Christine Kondratev Justine Rousseau Ah Jung Heo Katherine Neas Brett H. Graham Jill A. Rosenfeld Carlos A. Bacino Matias Wagner Maren Wenzel Fuad Al Mutairi Hamad Al Deiab Joseph G. Gleeson Valentina Stanley Maha S. Zaki Yong Tae Kwon Michel R. Leroux Philippe M. Campeau 《American journal of human genetics》2021,108(1):134-147
55.
Bogan Mustafa Al Behcet Kul Seval Zengin Suat Oktay Murat Sabak Mustafa Gümüşboğa Hasan Bayram Hasan 《International journal of biometeorology》2021,65(10):1733-1739
International Journal of Biometeorology - Epidemiological studies have suggested an association between particulate air pollution, increased temperatures, and morbidity related to pregnancy... 相似文献
56.
The axolotl, Ambystoma mexicanum, is used extensively for research in developmental biology, particularly for its ability to regenerate and restore lost organs, including in the nervous system, to full functionality. Regeneration in mammals typically depends on the healing process and scar formation with limited replacement of lost tissue. Other organisms, such as spiny mice (Acomys cahirinus), salamanders, and zebrafish, are able to regenerate some damaged body components. Blastema is a tissue that is formed after tissue injury in such organisms and is composed of progenitor cells or dedifferentiated cells that differentiate into various cell types during regeneration. Thus, identifying the molecules responsible for initiation of blastema formation is an important aspect for understanding regeneration. Introns, a major source of noncoding RNAs (ncRNAs), have characteristic sizes in the axolotl, particularly in genes associated with development. These ncRNAs, particularly microRNAs (miRNAs), exhibit dynamic regulation during regeneration. These miRNAs play an essential role in timing and control of gene expression to order and organize processes necessary for blastema creation. Master keys or molecules that underlie the remarkable regenerative abilities of the axolotl remain to be fully explored and exploited. Further and ongoing research on regeneration promises new knowledge that may allow improved repair and renewal of human tissues. 相似文献
57.
Farhan Haq Salmaan Sharif Adnan Khurshid Aamer Ikram Imran Shabbir Muhammad Salman Abdul Ahad Muhammad Suleman Rana Aroosha Raja Nazish Badar Hanaa Tashkandi Turki Al Amri Esam I. Azhar Mohammed S. Almuhayawi Steve Harakeh Muhammad Faraz Arshad Malik 《Saudi Journal of Biological Sciences》2021,28(1):942
58.
Al Bourgol Samy Ninotta Sandrine Garcin Thibaud Cognasse Fabrice Trone Marie-Caroline Forest Fabien Thuret Gilles Gain Philippe 《Cell and tissue banking》2021,22(3):479-486
Cell and Tissue Banking - The detection of corneas operated on for refractive surgery [LASIK or photorefractive keratectomy (PRK)] will become a major concern for eye banks in the coming years... 相似文献
59.
Urban expansion can be seen as the most pervasive human impact on the environment where its high resource use contributes negatively to climate change and resource scarcity crises. Many experts call for decoupling resource use, economic development, and related urban development especially within cities of the Global South. This paper focuses on investigating resource efficiency through the lens of urban metabolism. It investigates current resource flows, through material flow analysis, from source to sink, in two diverse districts in Cairo: a formal district and an informal one, regarding materials (waste) and mobility. Consequently, the paper discusses locally responsive interventions that address local priorities as opposing to citywide one‐size fits all solution. The paper relies on parcel audits, which are embedded in an Urban Metabolism Information System developed by the Ecocity Builders and their partners, through a joint project with Cairo University. The methodology couples crowd‐sourced data, parcel audits, and experts’ knowledge to better understand resource flows based on a bottom‐up approach, given the unavailability of governmental data on the local level. The paper further correlates the perceived quality of life with the actual resource flows. It utilizes fieldwork investigations to argue against the local misconceptions regarding the inefficiency of informal areas/systems versus the higher efficiency of planned areas/systems. The paper concludes by proposing integrated solutions that respond to local needs and resources. It highlights the challenges and lessons of this tailored bottom‐up approach and its applicability in other cities worldwide. 相似文献
60.
Yasmine Asaad Mansour El-Sayed M.M. Mosallam Shaymaa Hussein Ebtihal M.M. Elleithy Ihab M. Moussa Ayman S. Mubarak Turki M. Dawoud Roua A. Alsubki Jwaher H. Alhaji Hassan A. Hemeg Gehad A.H. EL-Bargeesy 《Saudi Journal of Biological Sciences》2021,28(1):217-223
This study illustrated the immunohistochemical distribution of androgen and vitamin D receptors of epididymis in 20 sexually mature ram (Rahmani breed) with average age ranged from (2_4) years and average weight ranged from (50_65kg). Androgen receptor was localized in the cytoplasm of both ciliated and non ciliated cells of efferent ductules, besides the principal cells via the entire epididymal duct. The principal cells of both corpus and proximal cauda epididymis showed the highest immunoreactivity to androgen receptors. Furthermore, vitamin D receptor was localized in the cytoplasm of all epithelium of the efferent ductules besides principal cells of all epididymal regions, however the immunoreaction was significantly higher in the efferent ductules, distal caput and distal cauda epididymis. In conclusion, these results suggest that the function of ram epididymis is regulated by both androgen and Vitamin D. 相似文献