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161.
Jukka Bisi Sami Kurki Marko Svensberg Tuija Liukkonen 《European Journal of Wildlife Research》2007,53(4):304-314
The growth of the Finnish wolf (Canis lupus) population during the last years has highlighted people’s contradictory attitudes toward wolves. The supranational conservation
objectives brought on by Finland’s membership in the European Union (EU) and the regional application of the official policy
on wolves have led to conflicts. This article is based on the preparation process of the wolf management plan in Finland.
As a part of the process, a nationwide hearing was arranged in 2004. Fear of wolves is widespread and even more common in
areas with low wolf population. People living in areas where wolves occur feel that they can no longer influence decision
making which affects them and that the authorities, conservationists, and the EU do not listen to their opinions. Numerous
requests have been made for the legislation and its interpretation, and concessions to these requests would promote consensus
and increase tolerance for wolves. Proposed changes include reforming the damage compensation system and formulating a clearer
interpretation of the conservation status of wolves. However, it seems impossible to create a policy that would be universally
supported. As the wolf question has become more central in environmental policy, the conservation and management of the species
have become more complicated, and the cooperation between various interest groups has declined. The wolf conflict could be
mitigated by compromises, but because the conflict is value-based, solutions are illusive. 相似文献
162.
Genetic analysis of disorder incidence in farmed animals is challenged by two factors. Disorders in different cohorts and environments could be caused by different factors, leading to changes in heritability and to less than unity genetic correlations across cohorts. Moreover, due to computational limitations, liability scale heritabilities at very low incidence may differ from those estimated at higher incidence. We tested whether these two dilemmas occur in skeletal deformations of farmed salmonids using multigeneration data from the Finnish rainbow trout breeding programme and previous salmonid studies. The results showed that heritability was close to zero in cohorts in which management practices maintained incidence at a low level. When there was a management failure and incidence was unusually high, heritability was elevated. This may be due to computational limitations at very low incidence and/or because deformations are induced by different factors in different cohorts. Most genetic correlations between deformations recorded in different generations were weakly to strongly positive. However, also negative correlations between generations were present, showing that high liability at one time can be genetically connected to low liability at another time. The results emphasise that genetic architecture of binary traits can be influenced by trait expression. 相似文献
163.
Jonathan K. L. Mak Laura Kananen Chenxi Qin Ralf Kuja-Halkola Bowen Tang Jake Lin Yunzhang Wang Tuija Jääskeläinen Seppo Koskinen Yi Lu Patrik K. E. Magnusson Sara Hägg Juulia Jylhävä 《Aging cell》2023,22(8):e13868
Identifying metabolic biomarkers of frailty, an age-related state of physiological decline, is important for understanding its metabolic underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magnetic resonance-based metabolomic biomarkers and 32 clinical biomarkers for their associations with frailty. In up to 90,573 UK Biobank participants, we identified 59 biomarkers robustly and independently associated with the frailty index (FI). Of these, 34 associations were replicated in the Swedish TwinGene study (n = 11,025) and the Finnish Health 2000 Survey (n = 6073). Using two-sample Mendelian randomization, we showed that the genetically predicted level of glycoprotein acetyls, an inflammatory marker, was statistically significantly associated with an increased FI (β per SD increase = 0.37%, 95% confidence interval: 0.12–0.61). Creatinine and several lipoprotein lipids were also associated with increased FI, yet their effects were mostly driven by kidney and cardiometabolic diseases, respectively. Our findings provide new insights into the causal effects of metabolites on frailty and highlight the role of chronic inflammation underlying frailty development. 相似文献
164.
Rolf Kümmerli Konstanze T. Schiessl Tuija Waldvogel Kristopher McNeill Martin Ackermann 《Ecology letters》2014,17(12):1536-1544
Bacteria typically rely on secreted metabolites, potentially shareable at the community level, to scavenge resources from the environment. The evolution of diffusible, shareable metabolites is, however, difficult to explain because molecules can get lost, or be exploited by cheating mutants. A key question is whether natural selection can act on molecule structure to control loss and shareability. We tested this possibility by collating information on diffusivity properties of 189 secreted iron‐scavenging siderophores and the natural habitats occupied by the siderophore‐producing species. In line with evolutionary theory, we found that highly diffusible siderophores have preferentially evolved in species living in structured habitats, such as soil and hosts, because structuring can keep producers and their shareable goods together. Poorly diffusible siderophores, meanwhile, have preferentially evolved in species living in unstructured habitats, such as seawater, indicating that these metabolites are less shareable and more likely provide direct benefits to the producers. 相似文献