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排序方式: 共有688条查询结果,搜索用时 562 毫秒
681.
Edward G. Muir 《BMJ (Clinical research ed.)》1969,1(5638):239-240
682.
Changes in the activities of several lysosomal enzymes were studied during transformation of mouse spleen cells in vitro. The activity of beta-glucuronidase increased during culture in the presence of T or B-cell mitogens, and lymphoblasts contained higher levels of activity than did small, non-transformed lymphocytes. Moreover, lymphoblasts in well-transformed cultures had higher activities than those in poorly-transformed cultures. The activities of other lysosomal enzymes (N-acetyl-beta-glucosaminidase, alpha-mannosidase, beta-glucosidase) also increased during mitogenic stimulation, but each at different rates, although aryl sulphatase was unaffected. Such differences may be of importance when lymphocytes are used for diagnosis of inherited lysosomal deficiency diseases. 相似文献
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R G Guidoin J Wallace R Mitchell W M Muir 《Revue fran?aise de transfusion et immuno-hématologie》1979,23(3):225-242
Microembolization by platelet leukocyte aggregates is a threat to the pulmonary microvasculature when blood is transfused to patients. Those aggregates can be removed by filters (either depth filter or screen filter); their efficiency, as shown by SFP measurements is not questionable, however they are working in different ways as observed by SEM: mechanical retention and adsorption. 相似文献
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Pressure-volume relationships in equine midcarpal joint 总被引:1,自引:0,他引:1
688.
Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating 总被引:5,自引:0,他引:5
S M Moghimi C J Porter I S Muir L Illum S S Davis 《Biochemical and biophysical research communications》1991,177(2):861-866
A recent development in prolonging the circulation time of drug carriers, such as liposomes and microspheres, has been to minimize their removal by macrophages of the reticuloendothelial system by covering their surface with hydrophilic polymers such as poloxamers, poloxamines and poly(ethyleneglycols). Here we demonstrate that this strategy may not necessarily prolong the circulatory half-life of drug carriers in all animal models. In rats, as opposed to rabbits, a non-phagocytic mechanism in the spleen may be triggered to remove efficiently from the blood drug carriers coated with hydrophilic coatings. Both the size of particle and its hydrophilic coating may act synergistically to trigger this non-phagocytic mechanism. In rats, a remarkable log to log relationship between particle size and spleen uptake was observed for both uncoated and polymeric coated microspheres. The potential implication of these observations in site-specific delivery of drug carriers is discussed. 相似文献