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31.
The cultures of Act. L10-0740 and L10-0772 were isolated from a soil sample. By their morphological and cultural features they were close to Act. badiocolor and differed from the latter by their antibiotic properties. Because of this they were classified as a new variant of Act. badiocolor var. abhasus var. nov. The cultures produced a new tetraen antibiotic, named abkhazomycin. Its physico-chemical properties are presented. 相似文献
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Chernysheva NB Tsyganov DV Philchenkov AA Zavelevich MP Kiselyov AS Semenov RV Semenova MN Semenov VV 《Bioorganic & medicinal chemistry letters》2012,22(7):2590-2593
A series of novel 4-oxa-podophyllotoxin derivatives 7 featuring the intact lactone ring D and various substituents in rings B and E has been synthesized and evaluated in a phenotypic sea urchin embryo assay along with the representative 4-aza-analogs 5 for their antimitotic and microtubule destabilizing activity. The most active compounds exhibited myristicin-derived or a 3',5'-dimethoxy substitution pattern in the ring E and a 6-methoxy moiety replacing the methylenedioxy ring A. Compounds 5xb, 5xe, 5yb, 7xa, 7xb, and 7xc showed potent antiproliferative effects in the NCI60 cytotoxicity screen. Notably, growth of the multi-drug resistant NCI/ADR-RES cells was more affected by these agents than the parent OVCAR-8 cell line. Although generally 4-oxa-podophyllotoxins were less potent than the respective 4-aza-derivatives in these assays, stability of the former series towards oxidation may prove to be of interest for the development of anticancer agents with in vivo activity. 相似文献
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Osipova MA Mortier V Demchenko KN Tsyganov VE Tikhonovich IA Lutova LA Dolgikh EA Goormachtig S 《Plant physiology》2012,158(3):1329-1341
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V.N. Biktashev I.V. Biktasheva A.V. Holden M.A. Tsyganov J. Brindley N.A. Hill 《Journal of biological physics》1999,25(2-3):101-113
If an excitable medium is moving with relative shear, the waves of excitation may be broken by the motion. We consider such breaks for the case of a constant linear shear flow. The mechanisms and conditions for the breaking of solitary waves and wavetrains are essentially different: the solitary waves require the velocity gradient to exceed a certain threshold, whilst the breaking of repetitive wavetrains happens for arbitrarily small velocity gradients. Since broken waves evolve into new spiral wave sources, this leads to spatio-temporal irregularity. 相似文献
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Tsyganov VV Sakharov DA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2000,86(9):1160-1166
Alkaloids (ergotamine and ergometrine) were shown to slow down rhythmic locomotion in even distantly related molluscs. The same is true for crawling pulmonate, pond snail Lymnaea stagnalis. The ergotamine activation of a powerful inhibitory input to pedal neurones involved in locomotor rhythmicity, was shown. The data obtained suggest that the conservative target for ergots is located outside rather than within the central pattern generator for locomotion. 相似文献
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Borisov AIu Vasil'chikov AG Voroshilova VA Danilova TN Zhernakov AI Zhukov VA Koroleva TA Kuznetsova EV Madsen L Mofett M Naumkina TS Nemankin TA Ovchinnikova ES Pavlova ZB Petrova NE Pinaev AG Radutoiu S Rozov SM Rychagova TS Solovov II Stougaard J Topunov AF Weeden NF Tsyganov VE Shtark OIu Tikhonovich IA 《Prikladnaia biokhimiia i mikrobiologiia》2007,43(3):265-271
The review sums up the long experience of the authors and other researchers in studying the genetic system of garden pea (Pisum sativum L.), which controls sthe development of nitrogen-fixing symbiosis and arbuscular mycorrhiza. A justified phenotypic classification of pea mutants is presented. Progress in identifying and cloning symbiotic genes is adequately reflected. The feasibility of using double inoculation as a means of increasing the plant productivity is demonstrated, in which the potential of a tripartite symbiotic system (pea plants-root nodule bacteria-arbuscular mycorrhiza) is mobilized. 相似文献