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101.
102.
Tetsuo Harada Shiho TakenakaTakero Sekimoto Yuhki OhsumiMitsuru Nakajyo Chihiro Katagiri 《Journal of thermal biology》2011,36(6):299-305
This study was performed to clarify how weather and current dynamics affect the resistance to temperature change in the oceanic sea skaters, Halobates. Heat coma temperature (HCT) was measured for the adults and 5th instar larvae of four Halobates species collected from a fixed sampling location (12°00′N, 135°00′E ) in western tropical Pacific Ocean and from 13 locations in the eastern area of the India Ocean ranging from 08°00′N-06°00′S and 86°00-76°00′E. Both the gap temperature for heat coma (GTHC, mean±SD: 7.83±1.86 °C, n=32) and the heat coma temperature (HCP, 35.03±1.80 °C, n=32) of individuals collected from the Pacific Ocean, during the first half (10 days) of the sampling period at the fixed sampling point, were significantly higher than those during the second half (GTHC: 5.10±2.05 °C, n=63; HCP: 34.03±2.02 °C, n=63). The reduction in heat tolerance shown in the second half of the 20 day period may have been caused by a decrease in air temperature due to rainfall that occurred around the sampling point accompanied with the arrival of Typhoon No. 6.In the study of individuals collected from the Indian Ocean, significantly higher average GTHCs of >8 °C were recorded for the adult H. micans collected at 02°00′S and 06°00′S (89°00′E) than those at 0°00-8°00′N in the eastern Indian Ocean. Dynamic mixture of water from northern and southern currents occurs at 02°00-6°00′S of the Indian Ocean and might relate to such high heat tolerance.Temperature dynamics in the ocean habitat might directly affect the temperature resistance of the oceanic sea skaters. 相似文献
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H Mochizuki K Suhara M Katagiri 《The Journal of steroid biochemistry and molecular biology》1990,37(1):133-136
Purified bovine P-450scc, the cholesterol side-chain cleaving P-450 in adrenal cortex mitochondria, was found to catalyze a deoxycorticosterone 6 beta-hydroxylase reaction. A turnover number (moles of product formed/min/mol of P-450) of 12 was found similar to that for cholesterol side chain cleavage activity. Conversion was dose-dependent in terms of P-450scc and no reaction took place when any one of the required electron donating components such as NADPH, NADPH-adrenodoxin reductase, or adrenodoxin was omitted. These results confirm and extend earlier observations that 21-hydroxypregnenolone is transformed into both deoxycorticosterone and 6 beta-hydroxydeoxycorticosterone by incubation of adrenal gland slices. 相似文献
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Nobuya Katagiri Hideaki Kokufuda Masashi Makino Robert Vince Chikara Kaneko 《Nucleosides, nucleotides & nucleic acids》2013,32(1-3):81-89
Abstract The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure. 相似文献
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Takeshi Fukuda Takashi Ishiyama Takahiro Katagiri Kenjiro Ueda Sumie Muramatsu Masami Hashimoto Anri Aki Daichi Baba Kengo Watanabe Naoki Tanaka 《Bioorganic & medicinal chemistry letters》2018,28(20):3333-3337
Hepcidin has emerged as the central regulatory molecule in systemic iron homeostasis. The inhibition of hepcidin may be a favorable strategy for the treatment of anemia of chronic disease. Here, we have reported the design, synthesis, and structure–activity relationships (SAR) of a series of 4-aminopyrimidine compounds as inhibitors of hepcidin production. The optimization study of 1 led to the design of a potent and bioavailable inhibitor of hepcidin production, 34 (DS42450411), which showed serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation. 相似文献
110.
Mikami K; Takahashi S; Katagiri T; Yamaguchi-Shinozaki K; Shinozaki K 《Journal of experimental botany》1999,50(334):729-730
Screening of an Arabidopsis cDNA library allowed the
isolation of a cDNA encoding a pleckstrin homology (PH) domain protein,
AtPH1, which consists of one PH domain with a short N-terminal extension.
According to its structural features, AtPH1 is proposed to be a plant
homologue of human pleckstrin. Northern blot analysis indicated that the
AtPH1 gene was expressed constitutively in all tissues
examined, with variation in the levels. The presence of a plant pleckstrin
homologue offers new insights into the biological function of the PH domain
in plant signalling. 相似文献