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581.
Kazuhiro Mawatari Shigeru Matsukawa Yoshimasa Yoneyama 《Biochemical and biophysical research communications》1983,114(1):318-324
The intensity of the Soret magnetic circular dichroism (MCD) spectra of various complexes of methemoglobin subunits (α+ and β+) as well as methemoglobin (metHb A) was correlated well with the spin states of ferric heme. Upon the subunit association, spin state transition toward higher spin was observed only in high spin derivatives and the changes in spin state were due to mainly those of β+ chains. The effect of an allostric effector, inositol hexaphosphate (IHP), on the MCD spectra of metHb A derivatives was observed much significantly for high spin forms than low spin ones. 相似文献
582.
583.
Biomaterials such as polyetherurethans (PEUs) are the scaffolding, which is indispensable for the development of the bio-artificial
organs. However, PEUs can induce tumors in subcutaneous implantation sites in rat. We have shown that the different inhibitory
potential of gap junctional intercellular communication (GJIC) on the surface of the biomaterials, including PEUs, is a key
step in determining the tumorigenic potential. Here we show that suppression of a gap junctional protein connexin 43 (Cx43)
plays an important role in in vivo tumorigenesis induced by PEUs for the first time and that Cx43 transfection may be an effective strategy for preventing tumorigenesis
induced by biomaterials. Rat tumor cell line U41 is derived from tumors in the subcutaneous implantation of PEU films. The
GJIC and the expression of Cx43 were suppressed in U41. The restoration of normal phenotype, such as reduction of growth rate,
recovery of contact inhibition and loss of colony formation ability in soft agar, was achieved by Cx43 transfection. These
results strongly suggest that suppression of Cx43 expression plays an important role in the development of rat malignant fibrous
histiocytoma (MFHC) caused by PEUs and that Cx43 transfection is effective for prevention of tumorigenesis induced by PEUs.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献