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71.
72.
This paper investigates the greenhouse gas emissions from a Swedish wetland, constructed to decrease nutrient content in sewage
treatment water. To evaluate the effect of the construction in terms of greenhouse gas emissions we carried out ecosystem-atmosphere
flux measurements of CO2, CH4 and N2O using a closed chamber technique. To evaluate the importance of vascular plant species composition to gas emissions we distributed
the measurement plots over the three dominating plant species at the field site, i.e., Typha latifolia, Phragmites australis and Juncus effusus. The fluxes of CO2 (total respiration), CH4 and N2O from vegetated plots ranged from 1.39 to 77.5 (g m−2 day−1), −377 to 1387 and −13.9 to 31.5 (mg m−2 day−1) for CO2, CH4 and N2O, respectively. Presence of vascular plants lead as expected to significantly higher total respiration rates compared with
un-vegetated control plots. Furthermore, we found that the emission rates of N2O and CH4 was affected by presence of vascular plants and tended to be species-specific. We assessed the integrated greenhouse warming
effect of the emissions using a Global Warming Potential over a 100-year horizon (GWP100) and it corresponded to 431 kg CO2 equivalents m−2 day−1. Assuming a 7-month season with conditions similar to the study period this is equal to 90 tonnes of CO2 equivalents annually. N2O emissions were responsible for one third of the estimated total greenhouse forcing. Furthermore, we estimated that the emission
from the forested bog that was the precursor land to Magle constructed wetland amounted to 18.6 tonnes of CO2 equivalents annually. Hence, the constructed wetland has increased annual greenhouse gas emissions by 71.4 tonnes of CO2 equivalents for the whole area. Our findings indicate that management processes in relation to wetland construction projects
must consider the primary function of the wetland in decreasing eutrophication, in relation to other positive aspects on for
instance plant and animal life and recreation as well as possible negative climatic aspects of increased emissions of CH4 and N2O. 相似文献
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Chromosomal rearrangements, which can lead to oncogene activation and tumour suppressor loss, are a hallmark of cancer cells. Such outcomes can result from both the repair and misrepair of DNA ends, which arise from a variety of lesions including DNA double strand breaks (DSBs), collapsed replication forks and dysfunctional telomeres. Here we review the mechanisms by which non-homologous end joining (NHEJ) and homologous recombination (HR) repair pathways can both promote chromosomal rearrangements and also suppress them in response to such lesions, in accordance with their increasingly recognised tumour suppressor function. Further, we consider how chromosomal rearrangements, together with a modular approach towards understanding their etiology, may be exploited for cancer therapy. 相似文献
77.
The use of high-density SNP arrays for investigating copy number alterations in clinical tumor samples, with intra tumor heterogeneity and varying degrees of normal cell contamination, imposes several problems for commonly used segmentation algorithms. This calls for flexibility when setting thresholds for calling gains and losses. In addition, sample normalization can induce artifacts in the copy-number ratios for the non-changed genomic elements in the tumor samples. RESULTS: We present an open source R package, Rseg, which allows the user to define sample-specific thresholds to call gains and losses. It also allows the user to correct for normalization artifacts. AVAILABILITY: The R package, Rseg, is available at: http://www.cs.au.dk/~plamy/Rseg/ and runs on Linux and MS-Windows. 相似文献
78.
Sandholt CH Vestmar MA Bille DS Borglykke A Almind K Hansen L Sandbæk A Lauritzen T Witte D Jørgensen T Pedersen O Hansen T 《PloS one》2011,6(9):e23531
Aims
Genome-wide association studies have identified novel BMI/obesity associated susceptibility loci. The purpose of this study is to determine associations with overweight, obesity, morbid obesity and/or general adiposity in a Danish population. Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms.Methods
15 gene variants in 14 loci including TMEM18 (rs7561317), SH2B1 (rs7498665), KCTD15 (rs29941), NEGR1 (rs2568958), ETV5 (rs7647305), BDNF (rs4923461, rs925946), SEC16B (rs10913469), FAIM2 (rs7138803), GNPDA2 (rs10938397), MTCH2 (rs10838738), BAT2 (rs2260000), NPC1 (rs1805081), MAF (rs1424233), and PTER (rs10508503) were genotyped in 18,014 middle-aged Danes.Results
Five of the 15 gene variants associated with overweight, obesity and/or morbid obesity. Per allele ORs ranged from 1.15–1.20 for overweight, 1.10–1.25 for obesity, and 1.41–1.46 for morbid obesity. Five of the 15 variants moreover associated with increased measures of adiposity. BDNF rs4923461 displayed a borderline BMI-dependent protective effect on type 2 diabetes (0.87 (0.78–0.96, p = 0.008)), whereas SH2B1 rs7498665 associated with nominally BMI-independent increased risk of type 2 diabetes (1.16 (1.07–1.27, p = 7.8×10−4)).Conclusions
Associations with overweight and/or obesity and measures of obesity were confirmed for seven out of the 15 gene variants. The obesity risk allele of BDNF rs4923461 protected against type 2 diabetes, which could suggest neuronal and peripheral distinctive ways of actions for the protein. SH2B1 rs7498665 associated with type 2 diabetes independently of BMI. 相似文献79.
Lavinia Paternoster David M. Evans Ellen Aagaard Nohr Claus Holst Valerie Gaborieau Paul Brennan Anette Prior Gjesing Niels Grarup Daniel R. Witte Torben J?rgensen Allan Linneberg Torsten Lauritzen Anelli Sandbaek Torben Hansen Oluf Pedersen Katherine S. Elliott John P. Kemp Beate St. Pourcain George McMahon Diana Zelenika J?rg Hager Mark Lathrop Nicholas J. Timpson George Davey Smith Thorkild I. A. S?rensen 《PloS one》2011,6(9)
80.
Shafizadeh TB Moler EJ Kolberg JA Nguyen UT Hansen T Jorgensen T Pedersen O Borch-Johnsen K 《PloS one》2011,6(7):e22863