全文获取类型
收费全文 | 1276篇 |
免费 | 145篇 |
出版年
2022年 | 12篇 |
2021年 | 16篇 |
2020年 | 11篇 |
2019年 | 14篇 |
2018年 | 13篇 |
2017年 | 14篇 |
2016年 | 21篇 |
2015年 | 41篇 |
2014年 | 43篇 |
2013年 | 40篇 |
2012年 | 53篇 |
2011年 | 50篇 |
2010年 | 33篇 |
2009年 | 26篇 |
2008年 | 40篇 |
2007年 | 47篇 |
2006年 | 53篇 |
2005年 | 45篇 |
2004年 | 44篇 |
2003年 | 39篇 |
2002年 | 43篇 |
2001年 | 22篇 |
2000年 | 29篇 |
1999年 | 32篇 |
1997年 | 16篇 |
1996年 | 17篇 |
1995年 | 17篇 |
1994年 | 14篇 |
1993年 | 15篇 |
1992年 | 39篇 |
1991年 | 34篇 |
1990年 | 30篇 |
1989年 | 42篇 |
1988年 | 28篇 |
1987年 | 27篇 |
1986年 | 28篇 |
1985年 | 28篇 |
1984年 | 41篇 |
1983年 | 21篇 |
1982年 | 20篇 |
1981年 | 22篇 |
1980年 | 16篇 |
1979年 | 14篇 |
1978年 | 16篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1974年 | 16篇 |
1973年 | 12篇 |
1972年 | 14篇 |
1967年 | 9篇 |
排序方式: 共有1421条查询结果,搜索用时 31 毫秒
81.
82.
83.
Amy V. Nalls Erin McNulty Jenny Powers Davis M. Seelig Clare Hoover Nicholas J. Haley Jeanette Hayes-Klug Kelly Anderson Paula Stewart Wilfred Goldmann Edward A. Hoover Candace K. Mathiason 《PloS one》2013,8(8)
The horizontal transmission of prion diseases has been well characterized in bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD) of deer and elk and scrapie of sheep, and has been regarded as the primary mode of transmission. Few studies have monitored the possibility of vertical transmission occurring within an infected mother during pregnancy. To study the potential for and pathway of vertical transmission of CWD in the native cervid species, we used a small cervid model–the polyestrous breeding, indoor maintainable, Reeves’ muntjac deer–and determined that the susceptibility and pathogenesis of CWD in these deer reproduce that in native mule and white-tailed deer. Moreover, we demonstrate here that CWD prions are transmitted from doe to fawn. Maternal CWD infection also appears to result in lower percentage of live birth offspring. In addition, evolving evidence from protein misfolding cyclic amplification (PMCA) assays on fetal tissues suggest that covert prion infection occurs in utero. Overall, our findings demonstrate that transmission of prions from mother to offspring can occur, and may be underestimated for all prion diseases. 相似文献
84.
Impacts of climate variability on tree demography in second growth tropical forests: the importance of regional context for predicting successional trajectories 下载免费PDF全文
María Uriarte Naomi Schwartz Jennifer S. Powers Erika Marín‐Spiotta Wenying Liao Leland K. Werden 《Biotropica》2016,48(6):780-797
Naturally regenerating and restored second growth forests account for over 70% of tropical forest cover and provide key ecosystem services. Understanding climate change impacts on successional trajectories of these ecosystems is critical for developing effective large‐scale forest landscape restoration (FLR) programs. Differences in environmental conditions, species composition, dynamics, and landscape context from old growth forests may exacerbate climate impacts on second growth stands. We compile data from 112 studies on the effects of natural climate variability, including warming, droughts, fires, and cyclonic storms, on demography and dynamics of second growth forest trees and identify variation in forest responses across biomes, regions, and landscapes. Across studies, drought decreases tree growth, survival, and recruitment, particularly during early succession, but the effects of temperature remain unexplored. Shifts in the frequency and severity of disturbance alter successional trajectories and increase the extent of second growth forests. Vulnerability to climate extremes is generally inversely related to long‐term exposure, which varies with historical climate and biogeography. The majority of studies, however, have been conducted in the Neotropics hindering generalization. Effects of fire and cyclonic storms often lead to positive feedbacks, increasing vulnerability to climate extremes and subsequent disturbance. Fragmentation increases forests’ vulnerability to fires, wind, and drought, while land use and other human activities influence the frequency and intensity of fire, potentially retarding succession. Comparative studies of climate effects on tropical forest succession across biogeographic regions are required to forecast the response of tropical forest landscapes to future climates and to implement effective FLR policies and programs in these landscapes. 相似文献
85.
Richard A. Watson Rob Mills C. L. Buckley Kostas Kouvaris Adam Jackson Simon T. Powers Chris Cox Simon Tudge Adam Davies Loizos Kounios Daniel Power 《Evolutionary biology》2016,43(4):553-581
The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation. However, current evolutionary theory is poorly equipped to describe how these organisations change over evolutionary time and especially how that results in adaptive complexes at successive scales of organisation (the key problem is that evolution is self-referential, i.e. the products of evolution change the parameters of the evolutionary process). Here we first reinterpret the central open questions in these domains from a perspective that emphasises the common underlying themes. We then synthesise the findings from a developing body of work that is building a new theoretical approach to these questions by converting well-understood theory and results from models of cognitive learning. Specifically, connectionist models of memory and learning demonstrate how simple incremental mechanisms, adjusting the relationships between individually-simple components, can produce organisations that exhibit complex system-level behaviours and improve the adaptive capabilities of the system. We use the term “evolutionary connectionism” to recognise that, by functionally equivalent processes, natural selection acting on the relationships within and between evolutionary entities can result in organisations that produce complex system-level behaviours in evolutionary systems and modify the adaptive capabilities of natural selection over time. We review the evidence supporting the functional equivalences between the domains of learning and of evolution, and discuss the potential for this to resolve conceptual problems in our understanding of the evolution of developmental, ecological and reproductive organisations and, in particular, the major evolutionary transitions. 相似文献
86.
87.
A. J. Tierney K. N. Hanzlik R. M. Hathaway C. Powers M. Roy 《Marine and Freshwater Behaviour and Physiology》2016,49(2):133-145
This laboratory study examined the effects of the specific serotonin reuptake inhibitor fluoxetine on growth following molting and on a range of behaviors in the crayfish Orconectes rusticus. For growth experiments, male Form I and Form II crayfish were weighed and measured and placed individually in water containing 0–500 μg/L of fluoxetine. They were held in fluoxetine or control water until they molted and were reweighed two weeks post-molt. In behavior experiments, juvenile and adult animals were held individually in 0, 2, 200, or 500 μg/L of fluoxetine for 10 days and tested in an open field arena to assess locomotion, thigmotaxis, sheltering, and habituation to a novel environment. Under our laboratory conditions, crayfish exposed to fluoxetine at 500 μg/L showed significantly enhanced growth: post-molt Form I animals had greater body weight and post-molt Form II animals had greater carapace length, relative to controls. In open field tests, juvenile crayfish exposed to 2 and 500 μg/L fluoxetine displayed significantly reduced locomotion compared to controls. The results indicate that crayfish growth and locomotion can be manipulated by short-term exposure to ambient fluoxetine, suggesting that this means of exposure may offer a useful and noninvasive way to examine drug effects in freely moving animals. However, effects were only observed at concentrations well above fluoxetine levels currently reported in the environment. This suggests that O. rusticus may be relatively resistant to this form of pharmaceutical pollution but whether effects would occur following long-term exposure to lower concentrations is unknown. 相似文献
88.
89.
Diane C. Saunders Marcela Brissova Neil Phillips Shristi Shrestha John T. Walker Radhika Aramandla Greg Poffenberger David K. Flaherty Kevin P. Weller Julie Pelletier Tracy Cooper Matt T. Goff John Virostko Alena Shostak E. Danielle Dean Dale L. Greiner Leonard D. Shultz Nripesh Prasad Alvin C. Powers 《Cell metabolism》2019,29(3):745-754.e4
90.