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31.
Massarigenin A (1) and papyracillic acids A (2) and B (3) were isolated from the endophytic fungus Microsphaeropsis sp. Their structures were elucidated by multidimensional nuclear magnetic resonance spectroscopy; the structure of massarigenin A (1) was also confirmed by X-ray crystallography. The absolute configuration of massarigenin A (1) was established by means of circular dichroism (CD) spectroscopy and time-dependent density functional theory (TDDFT) calculations. The impact of intermolecular hydrogen bonds detected in the crystal packing of 1 on CD spectra measured in the solid state was also investigated. 相似文献
32.
The mammalian target of rapamycin (mTOR) partner,raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif 总被引:12,自引:0,他引:12
Nojima H Tokunaga C Eguchi S Oshiro N Hidayat S Yoshino K Hara K Tanaka N Avruch J Yonezawa K 《The Journal of biological chemistry》2003,278(18):15461-15464
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Raptor (regulatory associated protein of mTOR) is a recently identified mTOR binding partner that also binds p70S6k and 4E-BP1 and is essential for TOR signaling in vivo. Herein we demonstrate that raptor binds to p70S6k and 4E-BP1 through their respective TOS (conserved TOR signaling) motifs to be required for amino acid- and mTOR-dependent regulation of these mTOR substrates in vivo. A point mutation of the TOS motif also eliminates all in vitro mTOR-catalyzed 4E-BP1 phosphorylation and abolishes the raptor-dependent component of mTOR-catalyzed p70S6k phosphorylation in vitro. Raptor appears to serve as an mTOR scaffold protein, the binding of which to the TOS motif of mTOR substrates is necessary for effective mTOR-catalyzed phosphorylation in vivo and perhaps for conferring their sensitivity to rapamycin and amino acid sufficiency. 相似文献
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34.
Chaiwat To-anun Jeerapa Nguenhom Jamjan Meeboon Iman Hidayat 《Mycological Progress》2009,8(2):115-121
Information on fungi associated with necrotic leaflets of exotic palms in Thailand is scanty, as previous studies were mainly
focused on decaying fronds. This study provides some information regarding fungi associated with necrotic leaflets of exotic
palms in Thailand. Specimens in this work were collected from several locations in Chiang Mai province, including natural
and planted areas. One new species, Cercospora arecacearum on areca palm (Areca catechu), is described and illustrated. An ITS sequence data analysis confirms the separation of the new Cercospora species from related taxa. Another species, Neorehmia arecae, hitherto only known from areca palm, is newly recorded for Thailand. Furthermore, Wallichia siamensis is a new host for this species. 相似文献
35.
Paul J. De Barro Sri Hendrastuti Hidayat Don Frohlich Siti Subandiyah Shigenori Ueda 《Biological invasions》2008,10(4):411-433
Bemisia tabaci is a species of sap-sucking insect belonging to the Aleyrodidae and are commonly known as whiteflies. The species is made
up of a complex of distinct genetic groups which have a strong geographic pattern to their genetic structure. Two members
of this complex known as the B and Q biotypes have proven to be particularly invasive, spreading with the aid of trade in
ornamental plants, well beyond their home ranges across the Mediterranean Basin, Middle East and Asia Minor. This study uses
DNA microsatellites to identify another biological invasion this time involving a B. tabaci from south east Asia. We provide evidence which supports an invasion sometime between 1994 and 1999 of B. tabaci from central Thailand into the Indonesian islands of Sumatra then Java and Bali. The invasion is also associated with the
invasion of pepper yellow leaf curl virus, a begomovirus transmitted by B. tabaci, which is also shown to have a probable origin in the same geographic region as the invading whitefly. The consequences of
the invasion of a plant-infecting virus and its vector has been a massive increase in the scale and impact of begomoviruses
in tomato and chilli production which has seen regional bans imposed on the planting of chilli, an important cash crop for
many village farmers in Sumatra and Java. 相似文献
36.
Muhammad Mithal Rind Samy Sayed Hakim Ali Sahito Khalid Hussain Rind Nadir Ali Rind Akhtar Hussain Shar Hidayat Ullah Peter Ondrisik Jana Ivanic Porhajosova Zihu GUO Mohamed Shahen 《Saudi Journal of Biological Sciences》2021,28(6):3186-3192
The dusky cotton bug (Oxycarenus laetus, KIRBY) a pest of several crops. The effects of winter and summer on the biology and morphology was investigated. The sampled eggs of dusky cotton bug (DCB) were kept under controlled environment for biological and morphological investigations. In winter, the mating duration of DCB was observed longer significantly (74.2 days), egg development period (3.93 days), an egg laying period (3.6 days) and hatching period (6.66 days) noted longer in winter season. Interestingly, average number of hatched egg (16.8 days) observed significantly higher in summer and the percentage of the hatching of eggs (81.95%) were also observed higher in summer as compare to winter. Whereas, the longevity of all nymph stages in winter longer days as compare to summer nymph stages. Moreover, differences were also observed between male and female development days between winter and summer. In the winter, female DCB development was suggestively higher as compare to summer (24 days). Whereas, the developmental days were noted considerably more in winter for males as compare to summer (14.93 days). On other hand, for morphological parameters, no differences were observed between winter and summer population of DCB. 相似文献
37.
Sukmal Fahri Benediktus Yohan Hidayat Trimarsanto S. Sayono Suharyo Hadisaputro Edi Dharmana Din Syafruddin R. Tedjo Sasmono 《PLoS neglected tropical diseases》2013,7(8)
Dengue disease is currently a major health problem in Indonesia and affects all provinces in the country, including Semarang Municipality, Central Java province. While dengue is endemic in this region, only limited data on the disease epidemiology is available. To understand the dynamics of dengue in Semarang, we conducted clinical, virological, and demographical surveillance of dengue in Semarang and its surrounding regions in 2012. Dengue cases were detected in both urban and rural areas located in various geographical features, including the coastal and highland areas. During an eight months'' study, a total of 120 febrile patients were recruited, of which 66 were serologically confirmed for dengue infection using IgG/IgM ELISA and/or NS1 tests. The cases occurred both in dry and wet seasons. Majority of patients were under 10 years old. Most patients were diagnosed as dengue hemorrhagic fever, followed by dengue shock syndrome and dengue fever. Serotyping was performed in 31 patients, and we observed the co-circulation of all four dengue virus (DENV) serotypes. When the serotypes were correlated with the severity of the disease, no direct correlation was observed. Phylogenetic analysis of DENV based on Envelope gene sequence revealed the circulation of DENV-2 Cosmopolitan genotype and DENV-3 Genotype I. A striking finding was observed for DENV-1, in which we found the co-circulation of Genotype I with an old Genotype II. The Genotype II was represented by a virus strain that has a very slow mutation rate and is very closely related to the DENV strain from Thailand, isolated in 1964 and never reported in other countries in the last three decades. Moreover, this virus was discovered in a cool highland area with an elevation of 1,001 meters above the sea level. The discovery of this old DENV strain may suggest the silent circulation of old virus strains in Indonesia. 相似文献
38.
Dilfaraz Khan Hidayat Ullah Khan Farmanullah Khan Shafiullah Khan Syed Badshah Abdul Samad Khan Abdul Samad Farman Ali Ihsanullah Khan Nawshad Muhammad 《PloS one》2014,9(4)
A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4-ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1–5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50% inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 µM while the values obtained against BChE were 5.98 and 9.84 µM respectively. Compounds 2 and 4 showed weak inhibition profile. 相似文献
39.
Jamjan Meeboon Iman Hidayat Kartini Kramadibrata Dian Nurcahyanto Siska Arie Santy Siahaan Susumu Takamatsu 《Mycoscience》2012,53(5):386-390
Cystotheca tjibodensis, formerly known as Lanomyces tjibodensis (Perisporiales), is a fungus found in 1920 in Indonesia. This species, hitherto only known from its type collection, is now regarded as belonging to the Erysiphales. However, molecular data are still required to verify the taxonomic affinity. In March 2011, we rediscovered this fungus at Cibodas Botanical Garden, Java. Detailed characterizations of this tropical powdery mildew are reported in this study based on morphological and molecular examinations. The anamorph of this species that was not found in the type specimen is also reported in this study. 相似文献
40.
Hidayat Hussain Natalia Root Farah Jabeen Ahmed Al‐Harrasi Manzoor Ahmad Fazal Mabood Zahid Hassan Afzal Shah Ivan R. Green Barbara Schulz Karsten Krohn 《化学与生物多样性》2015,12(2):289-294
A new polychlorinated triphenyl diether named microsphaerol ( 1 ), has been isolated from the endophtic fungus Microsphaeropsis sp. An intensive phytochemical investigation of the endophytic fungus Seimatosporium sp., led to the isolation of a new naphthalene derivative named seimatorone ( 2 ) and eight known compounds, i.e., 1‐(2,6‐dihydroxyphenyl)‐3‐hydroxybutan‐1‐one ( 3 ), 1‐(2,6‐dihydroxyphenyl)butan‐1‐one ( 4 ), 1‐(2‐hydroxy‐6‐methoxyphenyl)butan‐1‐one ( 5 ), 5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 6 ), 2,3‐dihydro‐5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 7 ), 8‐methoxynaphthalen‐1‐ol ( 8 ), nodulisporins A and B ( 9 and 10 , resp.), and daldinol ( 11 ). The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H‐ and 13C‐NMR, COSY, HMQC, HMBC, and HR‐EI‐MS, while the structures of the known compounds were deduced from comparison of their spectral data with those in the literature. Preliminary studies revealed that microsphaerol ( 1 ) showed good antibacterial activities against B. Megaterium and E. coli, and good antilagal and antifungal activities against C. fusca, M. violaceum, respectively. On the other hand, seimatorone ( 2 ) exhibited moderate antibacterial, antialgal, and antifungal activities. 相似文献