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231.
Maria Brbi? Matija Pi?korec Vedrana Vidulin Anita Kri?ko Tomislav ?muc Fran Supek 《Nucleic acids research》2016,44(21):10074-10090
Bacteria and Archaea display a variety of phenotypic traits and can adapt to diverse ecological niches. However, systematic annotation of prokaryotic phenotypes is lacking. We have therefore developed ProTraits, a resource containing ∼545 000 novel phenotype inferences, spanning 424 traits assigned to 3046 bacterial and archaeal species. These annotations were assigned by a computational pipeline that associates microbes with phenotypes by text-mining the scientific literature and the broader World Wide Web, while also being able to define novel concepts from unstructured text. Moreover, the ProTraits pipeline assigns phenotypes by drawing extensively on comparative genomics, capturing patterns in gene repertoires, codon usage biases, proteome composition and co-occurrence in metagenomes. Notably, we find that gene synteny is highly predictive of many phenotypes, and highlight examples of gene neighborhoods associated with spore-forming ability. A global analysis of trait interrelatedness outlined clusters in the microbial phenotype network, suggesting common genetic underpinnings. Our extended set of phenotype annotations allows detection of 57 088 high confidence gene-trait links, which recover many known associations involving sporulation, flagella, catalase activity, aerobicity, photosynthesis and other traits. Over 99% of the commonly occurring gene families are involved in genetic interactions conditional on at least one phenotype, suggesting that epistasis has a major role in shaping microbial gene content. 相似文献
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Jasna Hrenovic Mirela Rozic Tomislav Ivankovic Anamarija Farkas 《Central European Journal of Biology》2009,4(3):397-403
The aim of this study was to determine the potential of phosphate (P) removal from wastewater by biosolids prepared by the
immobilization of P-accumulating bacteria onto organic bentonite. Organic bentonite was prepared by treating bentonite clay
with quaternary ammonium salt — cetyltrimetylammonium (CTA) bromide. Cation exchange capacity (CEC) of the bentonite was found
to be 179.0 meq/100 g of the dry bentonite. The CTA occupied ca. 175% of the CEC. Modification of bentonite with CTA in amounts
higher than 55% of the CEC resulted in the change of zeta potential of particles from negative to positive. Only in reactors
containing organic bentonite samples occupied with 3.5 and 28% of the CEC was P efficiently removed from wastewater by combined
adsorption and bacterial uptake in the biomass. Organic bentonite samples with higher CTA loadings (from 55 to 175% of the
CEC) showed bactericidal effects. To enhance P removal from wastewater in the aerated biological system, biosolids consisting
of P-accumulating bacteria and organic bentonite can be used, but special attention should be given to the configuration of
sorbed CTA molecules and its potential desorption. 相似文献
235.
Aleš Snoj Andrej Razpet Tea Tomljanović Tomislav Treer Simona Sušnik 《Conservation Genetics》2007,8(5):1213-1217
Genetic founder effects of a historical translocation (1965; app. 12 generations ago) of endangered softmouth trout from the
only remaining indigenous population to an adjacent uninhabited river were investigated.
A comparison of 15 microsatellites from contemporary samples in both the source and re-established populations indicated a
very low level of genetic diversity within the two populations. Furthermore, considerable differences in estimates of variability
and effective population sizes were detected between populations, but no recent bottlenecks were evident. Our data suggest
that the re-established population has lost variation due to genetic drift associated with founder effects following the translocation.
Accordingly, in relation to management, we suggest that the re-established population could serve as a secondary source of
individuals to buffer possible extinction due to demographic events. Finally, conservation initiatives to enhance the census
population size and increase levels of variability in the re-established population are proposed.
Electronic Supplementary Material
Supplementary material is available in the online version of this article at and is accessible for authorized users. 相似文献
236.
How do environmental factors influence life cycles and development? An experimental framework for early‐diverging metazoans
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Thomas C. G. Bosch Maja Adamska René Augustin Tomislav Domazet‐Loso Sylvain Foret Sebastian Fraune Noriko Funayama Juris Grasis Mayuko Hamada Masayuki Hatta Bert Hobmayer Kotoe Kawai Alexander Klimovich Michael Manuel Chuya Shinzato Uli Technau Seungshic Yum David J. Miller 《BioEssays : news and reviews in molecular, cellular and developmental biology》2014,36(12):1185-1194
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Predrag Sikiric Sven Seiwerth Gorana Aralica Darko Perovic Mario Staresinic Tomislav Anic Miroslav Gjurasin Ingrid Prkacin Jadranka Separovic Dinko Stancic-Rokotov Martina Lovric-Bencic Darko Mikus Branko Turkovic Ivo Rotkvic Stjepan Mise Rudolf Rucman Marijan Petek Tihomil Ziger Bozidar Sebecic Zoran Ivasovic Vjekoslav Jagic Ljiljana Komericki Ivan Balen Alenka Boban-Blagaic Ivo Sjekavica 《Journal of Physiology》2001,95(1-6):283-288
After demonstration that cysteamine induced duodenal lesions in gastrectomized rats, while a number of antiulcer drugs mitigated these lesions, it was shown that one single intrarectal (i.r.) cysteamine application produced severe colon lesions in acute studies in rats. Thus, the further focus was on the protracted effect of cysteamine challenge (400 mg/kg b.w. i.r.) and therapy influence in chronic experiments in female rats. Regularly, cysteamine colon lesions were markedly mitigated by ranitidine (10), omeprazole (10), atropine (10), methylprednisolone (1), sulphasalazine (50; mg/kg), pentadecapeptide BPC 157 (PL-10, PLD-116; 10 microg or 10 ng/kg). Specifically, after 1 or 3 months following initial challenge (cysteamine 400 mg/kg i.r.) in female rat, the therapy [BPC 157 (PL-10, PLD-116 (10.0 microg or 10.0 ng/kg; i.g., i.p., i.r.), ranitidine, omeprazole, atropine, methylprednisolone, sulphasalazine (i.p.)] reversed the protracted cysteamine colon injury: the 1 week-regimen (once daily application) started after 1 month post-cysteamine, as well as the 2 weeks-regimen (once daily application), which started after 3 months. The effect on recidive lesion was also tested. These cysteamine lesions may reappear after stopping therapy (after stopping therapy for 3 weeks at the end of 2-weeks regimen started in 3 months-cysteamine female rats) in sulphasalazine group, while this reappearance is markedly antagonized in pentadecapeptide BPC 157 (PL-10, PLD-116)-rats (cysteamine-colon lesion still substantially low). 相似文献