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941.
Todd R Steck 《FEMS microbiology letters》1997,147(1):121-125
Agrobacterium tumefaciens can transfer the T-DNA region of a Ti plasmid to a recipient plant cell. An accepted model that describes the T-DNA transfer mechanism proposes that single-stranded T-complexes are transferred to a recipient plant via a conjugation-like mechanism. This model has been based on examination of a limited number of Ti plasmids. In this study, the type of processed T-DNA molecule created from multiple Ti plasmids was determined. The form of the processed T-DNA was found to vary and was correlated with whether the T-DNA region was organized as a single continuous region or two adjacent regions. 相似文献
942.
Todd R. Disotell 《American journal of physical anthropology》1999,110(4):474-476
The Natural History of the Doucs and Snub-Nosed Monkeys. Edited by Nina G. Jablonski. River Edge, NJ: World Scientific. 1998. 382 pp. ISBN 981-02-3131-8. $64.00 (cloth). 相似文献
943.
Temporal and spatial transcriptomic and microRNA dynamics of CAM photosynthesis in pineapple
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![点击此处可从《The Plant journal : for cell and molecular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
944.
Alessandra Bartolozzi Asitha Abeywardane Todd Bosanac John A. Broadwater Zhidong Chen J. Matthew Hutzler John D. Huber Peter Nemoto Alan Olague Doris Riether Tom Simpson Hidenori Takahashi Lifen Wu Yunlong Zhang Renee M. Zindell 《Bioorganic & medicinal chemistry letters》2017,27(20):4652-4659
Structure activity relationship (SAR) investigation of an oxadiazole based series led to the discovery of several potent FLAP inhibitors. Lead optimization focused on achieving functional activity while improving physiochemical properties and reducing hERG inhibition. Several compounds with favorable in vitro and in vivo properties were identified that were suitable for advanced profiling. 相似文献
945.
Variation in nestling body condition and wing development predict cause‐specific mortality in fledgling dickcissels
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![点击此处可从《Journal of avian biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Todd M. Jones Michael P. Ward Thomas J. Benson Jeffrey D. Brawn 《Journal of avian biology》2017,48(3):439-447
Phenotypic traits developed in one life‐history stage can carryover and affect survival in subsequent stages. For songbirds, carryover effects from the pre‐ to post‐fledging period may be crucial for survival but are poorly understood. We assessed whether juvenile body condition and wing development at fledging influenced survival during the post‐fledging period in the dickcissel Spiza americana. We found pre‐ to post‐fledging carryover effects on fledgling survival for both traits during the ‘early part’ – first four days – of the post‐fledging period. Survival benefits of each trait depended on cause‐specific sources of mortality; individuals in better body condition were less likely to die from exposure to adverse environmental conditions, whereas those with more advanced wing development were less likely to be preyed upon. Fledglings with more advanced wing development were comparatively more active and mobile earlier in the post‐fledging period, suggesting they were better able to avoid predators. Our results provide some of the first evidence linking development of juvenile phenotypic traits to survival against specific sources of post‐fledging mortality in songbirds. Further investigation into pre‐ to post‐fledging carryover effects may yield important insights into avian life‐history evolution. 相似文献
946.
Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate‐catabolizing bacteria
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![点击此处可从《Molecular microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Peng Wang Hai‐Yan Cao Xiu‐Lan Chen Chun‐Yang Li Ping‐Yi Li Xi‐Ying Zhang Qi‐Long Qin Jonathan D. Todd Yu‐Zhong Zhang 《Molecular microbiology》2017,105(5):674-688
Dimethylsulfoniopropionate (DMSP) cleavage, yielding dimethyl sulfide (DMS) and acrylate, provides vital carbon sources to marine bacteria, is a key component of the global sulfur cycle and effects atmospheric chemistry and potentially climate. Acrylate and its metabolite acryloyl‐CoA are toxic if allowed to accumulate within cells. Thus, organisms cleaving DMSP require effective systems for both the utilization and detoxification of acrylate. Here, we examine the mechanism of acrylate utilization and detoxification in Roseobacters. We propose propionate‐CoA ligase (PrpE) and acryloyl‐CoA reductase (AcuI) as the key enzymes involved and through structural and mutagenesis analyses, provide explanations of their catalytic mechanisms. In most cases, DMSP lyases and DMSP demethylases (DmdAs) have low substrate affinities, but AcuIs have very high substrate affinities, suggesting that an effective detoxification system for acylate catabolism exists in DMSP‐catabolizing Roseobacters. This study provides insight on acrylate metabolism and detoxification and a possible explanation for the high Km values that have been noted for some DMSP lyases. Since acrylate/acryloyl‐CoA is probably produced by other metabolism, and AcuI and PrpE are conserved in many organisms across all domains of life, the detoxification system is likely relevant to many metabolic processes and environments beyond DMSP catabolism. 相似文献
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Daryl L. Klindworth Jyoti Saini Yunming Long Matthew N. Rouse Justin D. Faris Yue Jin Steven S. Xu 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2017,130(6):1135-1154